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The effects of montelukast against amikacin-induced acute renal damage.
BACKGROUND AND OBJECTIVESThe therapeutic and protective effects of montelukast against amikacin-induced acute renal damage were investigated.
MATERIAL AND METHODS35 Wistar albino female rats were divided into 5 groups as follows: Group I: Control; Group II: Control+montelukast; Group III: Amikacin; Group IV: Amikacin+montelukast; Group V: Montelukast+amikacin. At the end of the experiment, the kidney tissues and the blood of rats were collected. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined from kidney tissues. Blood urea nitrogen (BUN), creatinine (Cr), TNF-alpha, and IL-1beta levels were assessed in the serum. In addition the kidney tissues were examined histologically.
RESULTS AND DISCUSSIONThe MDA, MPO, BUN, and Cr levels of group III significantly increased when compared to groups I and II. These parameters of group IV decreased when compared to group III. In addition, GSH levels significantly increased when compared to the first three groups. MDA, BUN and Cr levels of group V did not reach significant level in comparison with the control group. The most significant histological damage was observed in the group III followed by the groups IV and V. Immunohistochemically, group III showed a significantly increased apoptotic staining. In group IV, it was observed that montelukast treatment reduced the expression of apoptotic cells.
CONCLUSIONSMontelukast treatment after amikacin injection could reduce the amikacin-induced kidney damage.
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European review for medical and pharmacological sciences 16:4 2012 Apr pg 503-11
Blood Urea Nitrogen
Disease Models, Animal
Tumor Necrosis Factor-alpha
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't