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Association between spinal morning stiffness and lumbar disc degeneration: the Rotterdam Study.
Osteoarthritis Cartilage. 2012 Sep; 20(9):982-7.OC

Abstract

OBJECTIVE

To explore the associations between spinal morning stiffness and lumbar disc degeneration (LDD).

DESIGN

Data from a cross-sectional general population-based study (Rotterdam Study-I) were used. Intervertebral disc spaces and osteophytes of people aged ≥55 years were scored on lumbar lateral radiographs (L1-2 through L5-S1 was scored). Logistic regression analysis was used to explore associations between spinal morning stiffness and two definitions of LDD (i.e., 'narrowing' and 'osteophytes'). Spinal morning stiffness combined with low back pain and its association with LDD was also analyzed. Similar analyses were performed for knee and hip pain, morning stiffness in the legs, and radiographic knee and hip osteoarthritis (OA) in order to compare these associations with those of LDD. All analyses were adjusted for age, gender, and body mass index (BMI).

RESULTS

Lumbar lateral radiographs were scored for 2,819 participants. Both definitions of LDD were associated with spinal morning stiffness: adjusted odds ratio (aOR) 1.3; 95% confidence interval (CI): 1.1-1.6 for 'osteophytes' and aOR 1.8; 95% CI: 1.4-2.2 for 'narrowing'. Both the odds ratios increased when spinal morning stiffness was combined with low back pain: aOR 1.5; 95% CI: 1.1-2.0 for 'osteophytes' and aOR 2.5; 95% CI: 1.9-3.4 for 'narrowing'. When morning stiffness in the legs was combined with knee or hip pain, the associations with radiographic knee or hip OA were: aOR 3.0; 95% CI: 2.1-4.1 for knee OA and aOR 3.1; 95% CI: 1.9-5.0 for hip OA.

CONCLUSIONS

Reported spinal morning stiffness is associated with LDD. The associations increased when we combined spinal morning stiffness with low back pain. The magnitude of the association for the definition 'narrowing' is similar to the association between morning stiffness in the legs and knee or hip OA.

Authors+Show Affiliations

Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands. j.scheele@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22698441

Citation

Scheele, J, et al. "Association Between Spinal Morning Stiffness and Lumbar Disc Degeneration: the Rotterdam Study." Osteoarthritis and Cartilage, vol. 20, no. 9, 2012, pp. 982-7.
Scheele J, de Schepper EI, van Meurs JB, et al. Association between spinal morning stiffness and lumbar disc degeneration: the Rotterdam Study. Osteoarthritis Cartilage. 2012;20(9):982-7.
Scheele, J., de Schepper, E. I., van Meurs, J. B., Hofman, A., Koes, B. W., Luijsterburg, P. A., & Bierma-Zeinstra, S. M. (2012). Association between spinal morning stiffness and lumbar disc degeneration: the Rotterdam Study. Osteoarthritis and Cartilage, 20(9), 982-7. https://doi.org/10.1016/j.joca.2012.05.011
Scheele J, et al. Association Between Spinal Morning Stiffness and Lumbar Disc Degeneration: the Rotterdam Study. Osteoarthritis Cartilage. 2012;20(9):982-7. PubMed PMID: 22698441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between spinal morning stiffness and lumbar disc degeneration: the Rotterdam Study. AU - Scheele,J, AU - de Schepper,E I T, AU - van Meurs,J B J, AU - Hofman,A, AU - Koes,B W, AU - Luijsterburg,P A J, AU - Bierma-Zeinstra,S M A, Y1 - 2012/06/12/ PY - 2012/03/12/received PY - 2012/05/25/revised PY - 2012/05/29/accepted PY - 2012/6/16/entrez PY - 2012/6/16/pubmed PY - 2012/12/28/medline SP - 982 EP - 7 JF - Osteoarthritis and cartilage JO - Osteoarthritis Cartilage VL - 20 IS - 9 N2 - OBJECTIVE: To explore the associations between spinal morning stiffness and lumbar disc degeneration (LDD). DESIGN: Data from a cross-sectional general population-based study (Rotterdam Study-I) were used. Intervertebral disc spaces and osteophytes of people aged ≥55 years were scored on lumbar lateral radiographs (L1-2 through L5-S1 was scored). Logistic regression analysis was used to explore associations between spinal morning stiffness and two definitions of LDD (i.e., 'narrowing' and 'osteophytes'). Spinal morning stiffness combined with low back pain and its association with LDD was also analyzed. Similar analyses were performed for knee and hip pain, morning stiffness in the legs, and radiographic knee and hip osteoarthritis (OA) in order to compare these associations with those of LDD. All analyses were adjusted for age, gender, and body mass index (BMI). RESULTS: Lumbar lateral radiographs were scored for 2,819 participants. Both definitions of LDD were associated with spinal morning stiffness: adjusted odds ratio (aOR) 1.3; 95% confidence interval (CI): 1.1-1.6 for 'osteophytes' and aOR 1.8; 95% CI: 1.4-2.2 for 'narrowing'. Both the odds ratios increased when spinal morning stiffness was combined with low back pain: aOR 1.5; 95% CI: 1.1-2.0 for 'osteophytes' and aOR 2.5; 95% CI: 1.9-3.4 for 'narrowing'. When morning stiffness in the legs was combined with knee or hip pain, the associations with radiographic knee or hip OA were: aOR 3.0; 95% CI: 2.1-4.1 for knee OA and aOR 3.1; 95% CI: 1.9-5.0 for hip OA. CONCLUSIONS: Reported spinal morning stiffness is associated with LDD. The associations increased when we combined spinal morning stiffness with low back pain. The magnitude of the association for the definition 'narrowing' is similar to the association between morning stiffness in the legs and knee or hip OA. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/22698441/Association_between_spinal_morning_stiffness_and_lumbar_disc_degeneration:_the_Rotterdam_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1063-4584(12)00840-0 DB - PRIME DP - Unbound Medicine ER -