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[The different epidemic and evolution of HCV genotypes].
Yi Chuan. 2012 Jun; 34(6):666-72.YC

Abstract

Hepatitis C virus (HCV) is a prevalent and globally distributed human pathogen that currently infects an estimated 170 million people. Chronic HCV infection significantly increases the risk of chronic hepatitis. The virus exhibits a very high degree of genetic diversity that is classified six genotypes and sub-classified more than 80 subtypes by phylogenetic analysis. The various genotypes and subtypes of HCV have been associated with different epidemiological and geographical spread patterns. Genotypes 1 and 2 are globally distributed; genotype 3 is predominant in Asia, North America and parts of Europe; similar regional patterns of endemic diversity have been found for genotype 4 in Europe, Middle East and Central Africa, for genotype 5 in parts of Africa and Europe, and for genotype 6 in Southeast Asia and North America. Up to date, four HCV genotypes, including genotype 1, 2, 3 and 6, were identified in China. Genotypes 1b and 2a were mainly found in Northern China. The fast spreading of genotypes 3 and 6 in Southern and South-Western China was reported by recent studies. It's deduced that Yunnan may become an important source of HCV epidemic and spread, which will cause great changes in the distribution of HCV genotypes and subtypes, and a variety of transmission. With the development of evolution theory and related analysis methods, such as coalescent theory and evolutionary molecular, it is possible to understand the characters of virus evolution and migration. For HCV, the further understanding on the prevalence and evolution characters of various genotypes is very important for the deep investigation of HCV epidemic and the development of prevention strategy.

Authors+Show Affiliations

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. 861202_zl@163.comNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

chi

PubMed ID

22698736

Citation

Zhao, Lu, et al. "[The Different Epidemic and Evolution of HCV Genotypes]." Yi Chuan = Hereditas, vol. 34, no. 6, 2012, pp. 666-72.
Zhao L, Feng Y, Xia XS. [The different epidemic and evolution of HCV genotypes]. Yi Chuan. 2012;34(6):666-72.
Zhao, L., Feng, Y., & Xia, X. S. (2012). [The different epidemic and evolution of HCV genotypes]. Yi Chuan = Hereditas, 34(6), 666-72.
Zhao L, Feng Y, Xia XS. [The Different Epidemic and Evolution of HCV Genotypes]. Yi Chuan. 2012;34(6):666-72. PubMed PMID: 22698736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The different epidemic and evolution of HCV genotypes]. AU - Zhao,Lu, AU - Feng,Yue, AU - Xia,Xue-Shan, PY - 2012/6/16/entrez PY - 2012/6/16/pubmed PY - 2012/9/21/medline SP - 666 EP - 72 JF - Yi chuan = Hereditas JO - Yi Chuan VL - 34 IS - 6 N2 - Hepatitis C virus (HCV) is a prevalent and globally distributed human pathogen that currently infects an estimated 170 million people. Chronic HCV infection significantly increases the risk of chronic hepatitis. The virus exhibits a very high degree of genetic diversity that is classified six genotypes and sub-classified more than 80 subtypes by phylogenetic analysis. The various genotypes and subtypes of HCV have been associated with different epidemiological and geographical spread patterns. Genotypes 1 and 2 are globally distributed; genotype 3 is predominant in Asia, North America and parts of Europe; similar regional patterns of endemic diversity have been found for genotype 4 in Europe, Middle East and Central Africa, for genotype 5 in parts of Africa and Europe, and for genotype 6 in Southeast Asia and North America. Up to date, four HCV genotypes, including genotype 1, 2, 3 and 6, were identified in China. Genotypes 1b and 2a were mainly found in Northern China. The fast spreading of genotypes 3 and 6 in Southern and South-Western China was reported by recent studies. It's deduced that Yunnan may become an important source of HCV epidemic and spread, which will cause great changes in the distribution of HCV genotypes and subtypes, and a variety of transmission. With the development of evolution theory and related analysis methods, such as coalescent theory and evolutionary molecular, it is possible to understand the characters of virus evolution and migration. For HCV, the further understanding on the prevalence and evolution characters of various genotypes is very important for the deep investigation of HCV epidemic and the development of prevention strategy. SN - 0253-9772 UR - https://www.unboundmedicine.com/medline/citation/22698736/[The_different_epidemic_and_evolution_of_HCV_genotypes]_ L2 - https://medlineplus.gov/hepatitisc.html DB - PRIME DP - Unbound Medicine ER -