Tags

Type your tag names separated by a space and hit enter

Thiamine-deficient infant formula: what happened and what have we learned?
Ann Nutr Metab. 2012; 60(3):185-7.AN

Abstract

INTRODUCTION

In 2003, a thiamine-deficient soy infant formula was produced in Germany and marketed exclusively in Israel. Between October and November 2003, infants with encephalopathy were admitted to several intensive care units in Israel and were later diagnosed as suffering from thiamine deficiency. The soy formula consumed by these children was found to be the cause of these admissions.

METHODS

A Medline search using the terms 'thiamine deficiency' and 'formula' or 'feeding' without year limit identified relevant published data on that event. Newspapers from Israel were screened from November 2003 until April 2011.

RESULTS

On November 2003, 2-6% of infants in Israel consumed this formula. The consumption of this thiamine-deficient formula was associated with the death of 3 infants and with more than 20 infants manifesting neurologic damage. In this report, we summarize the chain of events, the neurologic outcome, and discuss the lessons needed to be learned from this sad event.

CONCLUSIONS

Based on difficulties in diagnosis of subtle deficiencies, we suggest that apparent history of safe use is not a reliable source for establishing adequate intake. Infant formulae can be produced or imported only under stringent criteria with the manufacturer/importer having total responsibility for the product.

Authors+Show Affiliations

Institute of Gastroenterology, Nutrition, and Liver Diseases, Schneider Children's Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. shamirraanan@gmail.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22699764

Citation

Shamir, Raanan. "Thiamine-deficient Infant Formula: what Happened and what Have We Learned?" Annals of Nutrition & Metabolism, vol. 60, no. 3, 2012, pp. 185-7.
Shamir R. Thiamine-deficient infant formula: what happened and what have we learned? Ann Nutr Metab. 2012;60(3):185-7.
Shamir, R. (2012). Thiamine-deficient infant formula: what happened and what have we learned? Annals of Nutrition & Metabolism, 60(3), 185-7. https://doi.org/10.1159/000338211
Shamir R. Thiamine-deficient Infant Formula: what Happened and what Have We Learned. Ann Nutr Metab. 2012;60(3):185-7. PubMed PMID: 22699764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thiamine-deficient infant formula: what happened and what have we learned? A1 - Shamir,Raanan, Y1 - 2012/06/06/ PY - 2012/6/16/entrez PY - 2012/6/16/pubmed PY - 2012/10/16/medline SP - 185 EP - 7 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 60 IS - 3 N2 - INTRODUCTION: In 2003, a thiamine-deficient soy infant formula was produced in Germany and marketed exclusively in Israel. Between October and November 2003, infants with encephalopathy were admitted to several intensive care units in Israel and were later diagnosed as suffering from thiamine deficiency. The soy formula consumed by these children was found to be the cause of these admissions. METHODS: A Medline search using the terms 'thiamine deficiency' and 'formula' or 'feeding' without year limit identified relevant published data on that event. Newspapers from Israel were screened from November 2003 until April 2011. RESULTS: On November 2003, 2-6% of infants in Israel consumed this formula. The consumption of this thiamine-deficient formula was associated with the death of 3 infants and with more than 20 infants manifesting neurologic damage. In this report, we summarize the chain of events, the neurologic outcome, and discuss the lessons needed to be learned from this sad event. CONCLUSIONS: Based on difficulties in diagnosis of subtle deficiencies, we suggest that apparent history of safe use is not a reliable source for establishing adequate intake. Infant formulae can be produced or imported only under stringent criteria with the manufacturer/importer having total responsibility for the product. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/22699764/Thiamine_deficient_infant_formula:_what_happened_and_what_have_we_learned L2 - https://www.karger.com?DOI=10.1159/000338211 DB - PRIME DP - Unbound Medicine ER -