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Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels.
Inflamm Res. 2012 Oct; 61(10):1117-24.IR

Abstract

OBJECTIVE

We reported the anti-inflammatory action of diphenyl diselenide [(PhSe)(2)] in an acute inflammation model induced by carrageenan.

MATERIALS

Male adult Swiss mice.

METHODS

Mice were treated with (PhSe)(2) (50 mg/kg) or vehicle (10 ml/kg) per oral route. After 30 min, animals received saline (0.1 ml) or saline containing 1 % carrageenan (0.1 ml) into the pleural cavity. Total and differential leukocyte counts, myeloperoxidase (MPO) activity, pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and interferon (INF)-γ] and reactive species (RS) were determined in pleural fluids. Pleural exudate accumulation was determined by Evans blue assay. Statistical analysis was performed by using a two-way ANOVA followed by the Duncan's test.

RESULTS

(PhSe)(2) treatment was effective against the increase in total and differential leukocyte counts, MPO activity, RS levels and pleural exudate caused by carrageenan. (PhSe)(2) partially protected against the increase in TNF-α, IL-1β, IL-6 and INF-γ levels induced by carrageenan. (PhSe)(2) had a similar anti-inflammatory profile to that of dexamethasone.

CONCLUSION

The anti-inflammatory property of (PhSe)(2) was demonstrated in the mouse model of pleurisy induced by carrageenan. The antioxidant property of (PhSe)(2) is related, at least in part, to the anti-inflammatory action of this compound.

Authors+Show Affiliations

Mestrado em Nanociências, Centro de Ciências Tecnológicas, Centro Universitário Franciscano, Santa Maria, RS CEP 97010-032, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22699806

Citation

Luchese, Cristiane, et al. "Diphenyl Diselenide Reduces Inflammation in the Mouse Model of Pleurisy Induced By Carrageenan: Reduction of Pro-inflammatory Markers and Reactive Species Levels." Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.], vol. 61, no. 10, 2012, pp. 1117-24.
Luchese C, Prigol M, Duarte MM, et al. Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels. Inflamm Res. 2012;61(10):1117-24.
Luchese, C., Prigol, M., Duarte, M. M., & Nogueira, C. W. (2012). Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels. Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.], 61(10), 1117-24. https://doi.org/10.1007/s00011-012-0504-0
Luchese C, et al. Diphenyl Diselenide Reduces Inflammation in the Mouse Model of Pleurisy Induced By Carrageenan: Reduction of Pro-inflammatory Markers and Reactive Species Levels. Inflamm Res. 2012;61(10):1117-24. PubMed PMID: 22699806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels. AU - Luchese,Cristiane, AU - Prigol,Marina, AU - Duarte,Marta M M F, AU - Nogueira,Cristina W, Y1 - 2012/06/15/ PY - 2011/11/22/received PY - 2012/05/29/accepted PY - 2012/05/24/revised PY - 2012/6/16/entrez PY - 2012/6/16/pubmed PY - 2013/1/30/medline SP - 1117 EP - 24 JF - Inflammation research : official journal of the European Histamine Research Society ... [et al.] JO - Inflamm Res VL - 61 IS - 10 N2 - OBJECTIVE: We reported the anti-inflammatory action of diphenyl diselenide [(PhSe)(2)] in an acute inflammation model induced by carrageenan. MATERIALS: Male adult Swiss mice. METHODS: Mice were treated with (PhSe)(2) (50 mg/kg) or vehicle (10 ml/kg) per oral route. After 30 min, animals received saline (0.1 ml) or saline containing 1 % carrageenan (0.1 ml) into the pleural cavity. Total and differential leukocyte counts, myeloperoxidase (MPO) activity, pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and interferon (INF)-γ] and reactive species (RS) were determined in pleural fluids. Pleural exudate accumulation was determined by Evans blue assay. Statistical analysis was performed by using a two-way ANOVA followed by the Duncan's test. RESULTS: (PhSe)(2) treatment was effective against the increase in total and differential leukocyte counts, MPO activity, RS levels and pleural exudate caused by carrageenan. (PhSe)(2) partially protected against the increase in TNF-α, IL-1β, IL-6 and INF-γ levels induced by carrageenan. (PhSe)(2) had a similar anti-inflammatory profile to that of dexamethasone. CONCLUSION: The anti-inflammatory property of (PhSe)(2) was demonstrated in the mouse model of pleurisy induced by carrageenan. The antioxidant property of (PhSe)(2) is related, at least in part, to the anti-inflammatory action of this compound. SN - 1420-908X UR - https://www.unboundmedicine.com/medline/citation/22699806/Diphenyl_diselenide_reduces_inflammation_in_the_mouse_model_of_pleurisy_induced_by_carrageenan:_reduction_of_pro_inflammatory_markers_and_reactive_species_levels_ L2 - https://dx.doi.org/10.1007/s00011-012-0504-0 DB - PRIME DP - Unbound Medicine ER -