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Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats.
Indian J Pharmacol. 2012 May; 44(3):377-81.IJ

Abstract

OBJECTIVES

Andrographis paniculata (Burm. f.) Nees originates from India and grows widely in many areas in Southeast Asian countries. Andrographis paniculata (Burm. f.) Nees has shown an antidiabetic effect in type 1 DM rats. The present study investigates the purified extract of the plant and its active compound andrographolide for antidiabetic and antihyperlipidemic effects in high-fructose-fat-fed rats, a model of type 2 DM rats.

MATERIALS AND METHODS

Hyperglycemia in rats was induced by high-fructose-fat diet containing 36% fructose, 15% lard, and 5% egg yolks in 0.36 g/200 gb.wt. 55 days. The rats were treated with the extract or test compound on the 50(th) day. Antidiabetic activity was measured by estimating mainly the pre- and postprandial blood glucose levels and other parameters such as cholesterol, LDL, triglyceride, and body weight.

RESULTS

The purified extract and andrographolide significantly (P<0.05) decreased the levels of blood glucose, triglyceride, and LDL compared to controls. However, no changes were observed in serum cholesterol and rat body weight. Metformin also showed similar effects on these parameters.

CONCLUSIONS

Andrographis paniculata (Burm. f.) Nees or its active compound andrographolide showed hypoglycemic and hypolipidemic effects in high-fat-fructose-fed rat.

Authors+Show Affiliations

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia. nugroho_ae@ugm.ac.idNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22701250

Citation

Nugroho, Agung Endro, et al. "Antidiabetic and Antihiperlipidemic Effect of Andrographis Paniculata (Burm. F.) Nees and Andrographolide in High-fructose-fat-fed Rats." Indian Journal of Pharmacology, vol. 44, no. 3, 2012, pp. 377-81.
Nugroho AE, Andrie M, Warditiani NK, et al. Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats. Indian J Pharmacol. 2012;44(3):377-81.
Nugroho, A. E., Andrie, M., Warditiani, N. K., Siswanto, E., Pramono, S., & Lukitaningsih, E. (2012). Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats. Indian Journal of Pharmacology, 44(3), 377-81. https://doi.org/10.4103/0253-7613.96343
Nugroho AE, et al. Antidiabetic and Antihiperlipidemic Effect of Andrographis Paniculata (Burm. F.) Nees and Andrographolide in High-fructose-fat-fed Rats. Indian J Pharmacol. 2012;44(3):377-81. PubMed PMID: 22701250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats. AU - Nugroho,Agung Endro, AU - Andrie,Mohamad, AU - Warditiani,Ni Kadek, AU - Siswanto,Eka, AU - Pramono,Suwidjiyo, AU - Lukitaningsih,Endang, PY - 2011/10/27/received PY - 2012/02/23/revised PY - 2012/02/28/accepted PY - 2012/6/16/entrez PY - 2012/6/16/pubmed PY - 2012/6/16/medline KW - Andrographis paniculata (Burm. f.) Nees KW - andrographolide KW - diabetes KW - fructose KW - hyperlipidemia SP - 377 EP - 81 JF - Indian journal of pharmacology JO - Indian J Pharmacol VL - 44 IS - 3 N2 - OBJECTIVES: Andrographis paniculata (Burm. f.) Nees originates from India and grows widely in many areas in Southeast Asian countries. Andrographis paniculata (Burm. f.) Nees has shown an antidiabetic effect in type 1 DM rats. The present study investigates the purified extract of the plant and its active compound andrographolide for antidiabetic and antihyperlipidemic effects in high-fructose-fat-fed rats, a model of type 2 DM rats. MATERIALS AND METHODS: Hyperglycemia in rats was induced by high-fructose-fat diet containing 36% fructose, 15% lard, and 5% egg yolks in 0.36 g/200 gb.wt. 55 days. The rats were treated with the extract or test compound on the 50(th) day. Antidiabetic activity was measured by estimating mainly the pre- and postprandial blood glucose levels and other parameters such as cholesterol, LDL, triglyceride, and body weight. RESULTS: The purified extract and andrographolide significantly (P<0.05) decreased the levels of blood glucose, triglyceride, and LDL compared to controls. However, no changes were observed in serum cholesterol and rat body weight. Metformin also showed similar effects on these parameters. CONCLUSIONS: Andrographis paniculata (Burm. f.) Nees or its active compound andrographolide showed hypoglycemic and hypolipidemic effects in high-fat-fructose-fed rat. SN - 1998-3751 UR - https://www.unboundmedicine.com/medline/citation/22701250/Antidiabetic_and_antihiperlipidemic_effect_of_Andrographis_paniculata__Burm__f___Nees_and_andrographolide_in_high_fructose_fat_fed_rats_ DB - PRIME DP - Unbound Medicine ER -
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