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Impact of rotavirus vaccines on rotavirus disease.
Expert Rev Anti Infect Ther 2012; 10(5):547-61ER

Abstract

Rotaviruses are the most common cause of acute gastroenteritis in young children worldwide. Both licensed rotavirus vaccines (Rotarix™ [RV1] and RotaTeq™ [RV5]) are effective and safe. Studies from countries that have included RV1 or RV5 in the national immunization programs have demonstrated their safety and sustained efficacy under real-life circumstances. A significant decline in acute gastroenteritis-related deaths among Latin American children was observed after the introduction of RV1 and RV5 vaccines. Both vaccines were able to decrease the number of cases of rotavirus acute gastroenteritis and of severe rotavirus diseases. Vaccination was also associated with a dramatic reduction in hospitalizations and outpatient visits for all-cause acute gastroenteritis. Indirect protection after infant mass vaccination has been strongly suggested. Moreover, postlicensure safety studies assessed rare adverse events (rates <1 in 50,000), such as intussusception.

Authors+Show Affiliations

Université Libre de Bruxelles and Infectious Diseases Unit, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium. philippe.lepage@huderf.beNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22702319

Citation

Lepage, Philippe, and Anne Vergison. "Impact of Rotavirus Vaccines On Rotavirus Disease." Expert Review of Anti-infective Therapy, vol. 10, no. 5, 2012, pp. 547-61.
Lepage P, Vergison A. Impact of rotavirus vaccines on rotavirus disease. Expert Rev Anti Infect Ther. 2012;10(5):547-61.
Lepage, P., & Vergison, A. (2012). Impact of rotavirus vaccines on rotavirus disease. Expert Review of Anti-infective Therapy, 10(5), pp. 547-61. doi:10.1586/eri.12.39.
Lepage P, Vergison A. Impact of Rotavirus Vaccines On Rotavirus Disease. Expert Rev Anti Infect Ther. 2012;10(5):547-61. PubMed PMID: 22702319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of rotavirus vaccines on rotavirus disease. AU - Lepage,Philippe, AU - Vergison,Anne, PY - 2012/6/19/entrez PY - 2012/6/19/pubmed PY - 2012/10/19/medline SP - 547 EP - 61 JF - Expert review of anti-infective therapy JO - Expert Rev Anti Infect Ther VL - 10 IS - 5 N2 - Rotaviruses are the most common cause of acute gastroenteritis in young children worldwide. Both licensed rotavirus vaccines (Rotarix™ [RV1] and RotaTeq™ [RV5]) are effective and safe. Studies from countries that have included RV1 or RV5 in the national immunization programs have demonstrated their safety and sustained efficacy under real-life circumstances. A significant decline in acute gastroenteritis-related deaths among Latin American children was observed after the introduction of RV1 and RV5 vaccines. Both vaccines were able to decrease the number of cases of rotavirus acute gastroenteritis and of severe rotavirus diseases. Vaccination was also associated with a dramatic reduction in hospitalizations and outpatient visits for all-cause acute gastroenteritis. Indirect protection after infant mass vaccination has been strongly suggested. Moreover, postlicensure safety studies assessed rare adverse events (rates <1 in 50,000), such as intussusception. SN - 1744-8336 UR - https://www.unboundmedicine.com/medline/citation/22702319/Impact_of_rotavirus_vaccines_on_rotavirus_disease_ L2 - http://www.tandfonline.com/doi/full/10.1586/eri.12.39 DB - PRIME DP - Unbound Medicine ER -