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Analysis of mite allergic patients in a diverse territory by improved diagnostic tools.
Clin Exp Allergy. 2012 Jul; 42(7):1129-38.CE

Abstract

BACKGROUND

There are few studies comparing the sensitization with mite allergens from different mite species which could potentially be the cause of allergy.

OBJECTIVE

To improve the diagnosis of mite allergic patients from a diverse territory in which D. pteronyssinus/D. farinae mites together with storage mites could be present in the environment.

METHODS

Four hundred and seventy-seven patients (both children and adults) from different regions, covering the main mite prevalent areas of Spain, were recruited. sIgE to eight allergens was measured together with SPT to whole mite extracts, level of mite allergen exposure, and specific IgG(4) . BAT and CAST was performed in a subgroup of patients.

RESULTS

D. pteronyssinus and L. destructor were more prevalent in Atlantic areas, whereas D. farinae predominate in Mediterranean areas. About 90% of patients were sensitized to group 1 and/or group 2 allergens. Group 2 was the most prevalent, and the IgE response/intensity of sensitization in BAT was higher. sIgE to Der p 2/Der f 2 was almost fully cross-reactive, but no cross-reactivity was detected with Lep d 2. Group 1 allergens were also cross-reactive, but in some patients a species-specific response was observed. sIgE to Lep d 2 was associated with SPT results to storage mites. Sensitization to Der p 1 was more frequent in children, whereas Lep d 2 sensitization was more frequent in adults. A higher ratio IgE/IgG(4) to Der p 2 was associated with the presence of allergic asthma.

CONCLUSION

An improved diagnosis algorithm has been established. Group 2 allergens seem to have a leading role in mite allergy, but as group 1 sensitization could be species-specific in some patients and its prevalence is higher in children, an adequate balance on major mite species and major allergens must be consider in the design of mite allergy vaccines.

Authors+Show Affiliations

Departamento de I+D, ALK-Abelló, Madrid/Hørsholm, Spain/Denmark. domingo.barber@alk-abello.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22702511

Citation

Barber, D, et al. "Analysis of Mite Allergic Patients in a Diverse Territory By Improved Diagnostic Tools." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 42, no. 7, 2012, pp. 1129-38.
Barber D, Arias J, Boquete M, et al. Analysis of mite allergic patients in a diverse territory by improved diagnostic tools. Clin Exp Allergy. 2012;42(7):1129-38.
Barber, D., Arias, J., Boquete, M., Cardona, V., Carrillo, T., Gala, G., Gamboa, P., García-Robaina, J. C., Hernández, D., Sanz, M. L., Tabar, A. I., Vidal, C., Ipsen, H., de la Torre, F., & Lombardero, M. (2012). Analysis of mite allergic patients in a diverse territory by improved diagnostic tools. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 42(7), 1129-38. https://doi.org/10.1111/j.1365-2222.2012.03993.x
Barber D, et al. Analysis of Mite Allergic Patients in a Diverse Territory By Improved Diagnostic Tools. Clin Exp Allergy. 2012;42(7):1129-38. PubMed PMID: 22702511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of mite allergic patients in a diverse territory by improved diagnostic tools. AU - Barber,D, AU - Arias,J, AU - Boquete,M, AU - Cardona,V, AU - Carrillo,T, AU - Gala,G, AU - Gamboa,P, AU - García-Robaina,J C, AU - Hernández,D, AU - Sanz,M L, AU - Tabar,A I, AU - Vidal,C, AU - Ipsen,H, AU - de la Torre,F, AU - Lombardero,M, PY - 2012/6/19/entrez PY - 2012/6/19/pubmed PY - 2012/10/19/medline SP - 1129 EP - 38 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 42 IS - 7 N2 - BACKGROUND: There are few studies comparing the sensitization with mite allergens from different mite species which could potentially be the cause of allergy. OBJECTIVE: To improve the diagnosis of mite allergic patients from a diverse territory in which D. pteronyssinus/D. farinae mites together with storage mites could be present in the environment. METHODS: Four hundred and seventy-seven patients (both children and adults) from different regions, covering the main mite prevalent areas of Spain, were recruited. sIgE to eight allergens was measured together with SPT to whole mite extracts, level of mite allergen exposure, and specific IgG(4) . BAT and CAST was performed in a subgroup of patients. RESULTS: D. pteronyssinus and L. destructor were more prevalent in Atlantic areas, whereas D. farinae predominate in Mediterranean areas. About 90% of patients were sensitized to group 1 and/or group 2 allergens. Group 2 was the most prevalent, and the IgE response/intensity of sensitization in BAT was higher. sIgE to Der p 2/Der f 2 was almost fully cross-reactive, but no cross-reactivity was detected with Lep d 2. Group 1 allergens were also cross-reactive, but in some patients a species-specific response was observed. sIgE to Lep d 2 was associated with SPT results to storage mites. Sensitization to Der p 1 was more frequent in children, whereas Lep d 2 sensitization was more frequent in adults. A higher ratio IgE/IgG(4) to Der p 2 was associated with the presence of allergic asthma. CONCLUSION: An improved diagnosis algorithm has been established. Group 2 allergens seem to have a leading role in mite allergy, but as group 1 sensitization could be species-specific in some patients and its prevalence is higher in children, an adequate balance on major mite species and major allergens must be consider in the design of mite allergy vaccines. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/22702511/Analysis_of_mite_allergic_patients_in_a_diverse_territory_by_improved_diagnostic_tools_ L2 - https://doi.org/10.1111/j.1365-2222.2012.03993.x DB - PRIME DP - Unbound Medicine ER -