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Indolent primary cutaneous γ/δ T-cell lymphoma localized to the subcutaneous panniculus and its association with atypical lymphocytic lobular panniculitis.
Am J Clin Pathol 2012; 138(1):50-6AJ

Abstract

The 2005 classification of lymphoma proposed the designation of subcutaneous panniculitis-like T-cell lymphoma exclusively for those tumors composed of α/β neoplastic cells. Subcutaneous lymphomas that comprised γ/δ T cells are termed primary cutaneous γ/δ T-cell lymphoma. The different clinical outcomes justified this separation; a more indolent course was characteristic of the α/β variants vs the poor 5-year survival of the γ/δ forms. We describe 5 patients with γ/δ T-cell lymphoma localized to the subcutis with a less aggressive clinical course. Two patients were alive 5 years after presentation, and in the remaining 3, the disease is in complete remission after simple intervention. Three patients had a waxing and waning phase, likely representing a prelymphomatous phase, which then progressed to an overt malignant tumor. Therefore, it is important to recognize that not all patients with γ/δ T-cell lymphomas have a poor prognosis.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Room F-309, 1300 York Ave, Weill Medical College of Cornell University, New York, NY, USA. cym2003@med.cornell.eduNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22706857

Citation

Magro, Cynthia M., and Xuan Wang. "Indolent Primary Cutaneous Γ/δ T-cell Lymphoma Localized to the Subcutaneous Panniculus and Its Association With Atypical Lymphocytic Lobular Panniculitis." American Journal of Clinical Pathology, vol. 138, no. 1, 2012, pp. 50-6.
Magro CM, Wang X. Indolent primary cutaneous γ/δ T-cell lymphoma localized to the subcutaneous panniculus and its association with atypical lymphocytic lobular panniculitis. Am J Clin Pathol. 2012;138(1):50-6.
Magro, C. M., & Wang, X. (2012). Indolent primary cutaneous γ/δ T-cell lymphoma localized to the subcutaneous panniculus and its association with atypical lymphocytic lobular panniculitis. American Journal of Clinical Pathology, 138(1), pp. 50-6. doi:10.1309/AJCPQGVLTZQ77VFF.
Magro CM, Wang X. Indolent Primary Cutaneous Γ/δ T-cell Lymphoma Localized to the Subcutaneous Panniculus and Its Association With Atypical Lymphocytic Lobular Panniculitis. Am J Clin Pathol. 2012;138(1):50-6. PubMed PMID: 22706857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indolent primary cutaneous γ/δ T-cell lymphoma localized to the subcutaneous panniculus and its association with atypical lymphocytic lobular panniculitis. AU - Magro,Cynthia M, AU - Wang,Xuan, PY - 2012/6/19/entrez PY - 2012/6/19/pubmed PY - 2013/1/19/medline SP - 50 EP - 6 JF - American journal of clinical pathology JO - Am. J. Clin. Pathol. VL - 138 IS - 1 N2 - The 2005 classification of lymphoma proposed the designation of subcutaneous panniculitis-like T-cell lymphoma exclusively for those tumors composed of α/β neoplastic cells. Subcutaneous lymphomas that comprised γ/δ T cells are termed primary cutaneous γ/δ T-cell lymphoma. The different clinical outcomes justified this separation; a more indolent course was characteristic of the α/β variants vs the poor 5-year survival of the γ/δ forms. We describe 5 patients with γ/δ T-cell lymphoma localized to the subcutis with a less aggressive clinical course. Two patients were alive 5 years after presentation, and in the remaining 3, the disease is in complete remission after simple intervention. Three patients had a waxing and waning phase, likely representing a prelymphomatous phase, which then progressed to an overt malignant tumor. Therefore, it is important to recognize that not all patients with γ/δ T-cell lymphomas have a poor prognosis. SN - 1943-7722 UR - https://www.unboundmedicine.com/medline/citation/22706857/Indolent_primary_cutaneous_γ/δ_T_cell_lymphoma_localized_to_the_subcutaneous_panniculus_and_its_association_with_atypical_lymphocytic_lobular_panniculitis_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/AJCPQGVLTZQ77VFF DB - PRIME DP - Unbound Medicine ER -