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HPV testing is an efficient management choice for women with inadequate liquid-based cytology in cervical cancer screening.
Am J Clin Pathol 2012; 138(1):65-71AJ

Abstract

This study compares colposcopy referrals of 2 management strategies: oncogenic human papillomavirus (HPV)-DNA testing (Hybrid Capture 2 assay, Qiagen, Germantown, MD) and repeat cytology. In the New Technology in Cervical Cancer Trial, 22,708 subjects were randomly assigned to undergo both HPV and liquid-based cytologic testing. Women aged 35 to 60 years old with unsatisfactory cytologic findings were directly referred for colposcopy if the HPV test result was positive, and were referred for repeat cytologic examination if the HPV test result was negative; women aged 25 to 35 years old were referred for repeat cytologic examination independent of HPV test results. A positive or a second unsatisfactory cytologic examination referred women for colposcopy. Five hundred sixty women had unsatisfactory cytologic findings. Colposcopy referral was not significant and slightly higher with HPV testing than repeat cytologic test (9.8% vs 6.8%, P = .11). When cytologic testing was repeated 36.8% were unavailable for follow-up and most of the colposcopies were performed in HPV-negative women. For unsatisfactory cytologic findings, HPV triage is a more logical and efficient management strategy than a repeat cytologic test.

Authors+Show Affiliations

AUSL Reggio Emilia, Epidemiology Unit, via Amendola 2, Reggio Emilia, 42122 Italy. paolo.giorgirossi@ausl.re.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22706859

Citation

Giorgi Rossi, Paolo, et al. "HPV Testing Is an Efficient Management Choice for Women With Inadequate Liquid-based Cytology in Cervical Cancer Screening." American Journal of Clinical Pathology, vol. 138, no. 1, 2012, pp. 65-71.
Giorgi Rossi P, Carozzi F, Collina G, et al. HPV testing is an efficient management choice for women with inadequate liquid-based cytology in cervical cancer screening. Am J Clin Pathol. 2012;138(1):65-71.
Giorgi Rossi, P., Carozzi, F., Collina, G., Confortini, M., Dalla Palma, P., De Lillo, M., ... Ronco, G. (2012). HPV testing is an efficient management choice for women with inadequate liquid-based cytology in cervical cancer screening. American Journal of Clinical Pathology, 138(1), pp. 65-71. doi:10.1309/AJCP6J2OEFOYTRFD.
Giorgi Rossi P, et al. HPV Testing Is an Efficient Management Choice for Women With Inadequate Liquid-based Cytology in Cervical Cancer Screening. Am J Clin Pathol. 2012;138(1):65-71. PubMed PMID: 22706859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HPV testing is an efficient management choice for women with inadequate liquid-based cytology in cervical cancer screening. AU - Giorgi Rossi,Paolo, AU - Carozzi,Francesca, AU - Collina,Guido, AU - Confortini,Massimo, AU - Dalla Palma,Paolo, AU - De Lillo,Margherita, AU - Del Mistro,Annarosa, AU - Ghiringhello,Bruno, AU - Gillio-Tos,Anna, AU - Maioli,Patrizia, AU - Pellegrini,Antonella, AU - Schiboni,Maria Luisa, AU - Segnan,Nereo, AU - Zaffina,Leandra M T, AU - Zorzi,Manuel, AU - Ronco,Guglielmo, AU - ,, PY - 2012/6/19/entrez PY - 2012/6/19/pubmed PY - 2013/1/19/medline SP - 65 EP - 71 JF - American journal of clinical pathology JO - Am. J. Clin. Pathol. VL - 138 IS - 1 N2 - This study compares colposcopy referrals of 2 management strategies: oncogenic human papillomavirus (HPV)-DNA testing (Hybrid Capture 2 assay, Qiagen, Germantown, MD) and repeat cytology. In the New Technology in Cervical Cancer Trial, 22,708 subjects were randomly assigned to undergo both HPV and liquid-based cytologic testing. Women aged 35 to 60 years old with unsatisfactory cytologic findings were directly referred for colposcopy if the HPV test result was positive, and were referred for repeat cytologic examination if the HPV test result was negative; women aged 25 to 35 years old were referred for repeat cytologic examination independent of HPV test results. A positive or a second unsatisfactory cytologic examination referred women for colposcopy. Five hundred sixty women had unsatisfactory cytologic findings. Colposcopy referral was not significant and slightly higher with HPV testing than repeat cytologic test (9.8% vs 6.8%, P = .11). When cytologic testing was repeated 36.8% were unavailable for follow-up and most of the colposcopies were performed in HPV-negative women. For unsatisfactory cytologic findings, HPV triage is a more logical and efficient management strategy than a repeat cytologic test. SN - 1943-7722 UR - https://www.unboundmedicine.com/medline/citation/22706859/HPV_testing_is_an_efficient_management_choice_for_women_with_inadequate_liquid_based_cytology_in_cervical_cancer_screening_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/AJCP6J2OEFOYTRFD DB - PRIME DP - Unbound Medicine ER -