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The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion.
Mol Nutr Food Res. 2012 Jun; 56(6):966-75.MN

Abstract

SCOPE

Evidence for the benefits of green tea catechins on vascular function is inconsistent, with genotype potentially contributing to the heterogeneity in response. Here, the impact of the catechol-O-methyltransferase (COMT) genotype on vascular function and blood pressure (BP) after green tea extract ingestion are reported.

METHODS AND RESULTS

Fifty subjects (n = 25 of the proposed low-activity [AA] and of the high-activity [GG] COMT rs4680 genotype), completed a randomized, double-blind, crossover study. Peripheral arterial tonometry, digital volume pulse (DVP), and BP were assessed at baseline and 90 min after 1.06 g of green tea extract or placebo. A 5.5 h and subsequent 18.5 h urine collection was performed to assess green tea catechin excretion. A genotype × treatment interaction was observed for DVP reflection index (p = 0.014), with green tea extract in the AA COMT group attenuating the increase observed with placebo. A tendency for a greater increase in diastolic BP was evident at 90 min after the green tea extract compared to placebo (p = 0.07). A genotypic effect was observed for urinary methylated epigallocatechin during the first 5.5 h, with the GG COMT group demonstrating a greater concentration (p = 0.049).

CONCLUSION

Differences in small vessel tone according to COMT genotype were evident after acute green tea extract.

Authors+Show Affiliations

Department of Food and Nutritional Sciences, University of Reading, Reading, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22707271

Citation

Miller, Rosalind J., et al. "The Impact of the catechol-O-methyltransferase Genotype On Vascular Function and Blood Pressure After Acute Green Tea Ingestion." Molecular Nutrition & Food Research, vol. 56, no. 6, 2012, pp. 966-75.
Miller RJ, Jackson KG, Dadd T, et al. The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. Mol Nutr Food Res. 2012;56(6):966-75.
Miller, R. J., Jackson, K. G., Dadd, T., Mayes, A. E., Brown, A. L., Lovegrove, J. A., & Minihane, A. M. (2012). The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. Molecular Nutrition & Food Research, 56(6), 966-75. https://doi.org/10.1002/mnfr.201100726
Miller RJ, et al. The Impact of the catechol-O-methyltransferase Genotype On Vascular Function and Blood Pressure After Acute Green Tea Ingestion. Mol Nutr Food Res. 2012;56(6):966-75. PubMed PMID: 22707271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. AU - Miller,Rosalind J, AU - Jackson,Kim G, AU - Dadd,Tony, AU - Mayes,Andrew E, AU - Brown,A Louise, AU - Lovegrove,Julie A, AU - Minihane,Anne M, PY - 2012/6/19/entrez PY - 2012/6/19/pubmed PY - 2012/10/19/medline SP - 966 EP - 75 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 56 IS - 6 N2 - SCOPE: Evidence for the benefits of green tea catechins on vascular function is inconsistent, with genotype potentially contributing to the heterogeneity in response. Here, the impact of the catechol-O-methyltransferase (COMT) genotype on vascular function and blood pressure (BP) after green tea extract ingestion are reported. METHODS AND RESULTS: Fifty subjects (n = 25 of the proposed low-activity [AA] and of the high-activity [GG] COMT rs4680 genotype), completed a randomized, double-blind, crossover study. Peripheral arterial tonometry, digital volume pulse (DVP), and BP were assessed at baseline and 90 min after 1.06 g of green tea extract or placebo. A 5.5 h and subsequent 18.5 h urine collection was performed to assess green tea catechin excretion. A genotype × treatment interaction was observed for DVP reflection index (p = 0.014), with green tea extract in the AA COMT group attenuating the increase observed with placebo. A tendency for a greater increase in diastolic BP was evident at 90 min after the green tea extract compared to placebo (p = 0.07). A genotypic effect was observed for urinary methylated epigallocatechin during the first 5.5 h, with the GG COMT group demonstrating a greater concentration (p = 0.049). CONCLUSION: Differences in small vessel tone according to COMT genotype were evident after acute green tea extract. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/22707271/The_impact_of_the_catechol_O_methyltransferase_genotype_on_vascular_function_and_blood_pressure_after_acute_green_tea_ingestion_ L2 - https://doi.org/10.1002/mnfr.201100726 DB - PRIME DP - Unbound Medicine ER -