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Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes.
Thorax. 2012 Nov; 67(11):950-6.T

Abstract

BACKGROUND

Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma.

OBJECTIVE

To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function.

METHODS

Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children.

RESULTS

There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function.

CONCLUSIONS

This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.

Authors+Show Affiliations

Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22707522

Citation

Pike, Katharine C., et al. "Maternal Late-pregnancy Serum 25-hydroxyvitamin D in Relation to Childhood Wheeze and Atopic Outcomes." Thorax, vol. 67, no. 11, 2012, pp. 950-6.
Pike KC, Inskip HM, Robinson S, et al. Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax. 2012;67(11):950-6.
Pike, K. C., Inskip, H. M., Robinson, S., Lucas, J. S., Cooper, C., Harvey, N. C., Godfrey, K. M., & Roberts, G. (2012). Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax, 67(11), 950-6. https://doi.org/10.1136/thoraxjnl-2012-201888
Pike KC, et al. Maternal Late-pregnancy Serum 25-hydroxyvitamin D in Relation to Childhood Wheeze and Atopic Outcomes. Thorax. 2012;67(11):950-6. PubMed PMID: 22707522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. AU - Pike,Katharine C, AU - Inskip,Hazel M, AU - Robinson,Sian, AU - Lucas,Jane S, AU - Cooper,Cyrus, AU - Harvey,Nicholas C, AU - Godfrey,Keith M, AU - Roberts,Graham, AU - ,, Y1 - 2012/06/15/ PY - 2012/6/19/entrez PY - 2012/6/19/pubmed PY - 2013/1/10/medline SP - 950 EP - 6 JF - Thorax JO - Thorax VL - 67 IS - 11 N2 - BACKGROUND: Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma. OBJECTIVE: To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function. METHODS: Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children. RESULTS: There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function. CONCLUSIONS: This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/22707522/Maternal_late_pregnancy_serum_25_hydroxyvitamin_D_in_relation_to_childhood_wheeze_and_atopic_outcomes_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=22707522 DB - PRIME DP - Unbound Medicine ER -