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Increased frequency of osteoporosis and BMD below the expected range for age among South Korean women with rheumatoid arthritis.
Int J Rheum Dis. 2012 Jun; 15(3):289-96.IJ

Abstract

OBJECTIVE

To compare the frequency of osteoporosis and bone mineral density (BMD) below the expected range for age between female patients with rheumatoid arthritis (RA) and healthy subjects and to determine risk factors for bone loss in female patients with RA.

METHOD

Two hundred and ninety-nine patients with RA and 246 age-matched healthy subjects were included in this study. BMD in the lumbar spine, femoral neck and total hip were measured with dual-energy X-ray absorptiometry. A T-score of -2.5 or lower in postmenopausal women was defined as osteoporosis, and a Z-score -2.0 or lower in females prior to menopause was defined as below the expected range for age.

RESULT

The frequency of osteoporosis in the RA patients (22.1%) was significantly higher than in healthy subjects (11.4%) at either the spine or hip (P = 0.014). The occurrence of BMD below the expected range for age in RA patients (7.8%) was also significantly higher than in healthy subjects (1.0%, P = 0.015). In 299 female patients with RA, higher age, lower body mass index and postmenopausal status were significantly associated with the lumbar spine and hip BMD reduction. Of disease-related variables, glucocorticoid use was independently associated with reduction of hip BMD.

CONCLUSION

The prevalence of osteoporosis in the RA patients was 1.9 times higher than in healthy subjects. Glucocorticoid use was a risk factor for generalized bone loss in female RA patients.

Authors+Show Affiliations

Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22709491

Citation

Lee, Seung-Geun, et al. "Increased Frequency of Osteoporosis and BMD Below the Expected Range for Age Among South Korean Women With Rheumatoid Arthritis." International Journal of Rheumatic Diseases, vol. 15, no. 3, 2012, pp. 289-96.
Lee SG, Park YE, Park SH, et al. Increased frequency of osteoporosis and BMD below the expected range for age among South Korean women with rheumatoid arthritis. Int J Rheum Dis. 2012;15(3):289-96.
Lee, S. G., Park, Y. E., Park, S. H., Kim, T. K., Choi, H. J., Lee, S. J., Kim, S. I., Lee, S. H., Kim, G. T., Lee, J. W., Lee, J. H., & Baek, S. H. (2012). Increased frequency of osteoporosis and BMD below the expected range for age among South Korean women with rheumatoid arthritis. International Journal of Rheumatic Diseases, 15(3), 289-96. https://doi.org/10.1111/j.1756-185X.2012.01729.x
Lee SG, et al. Increased Frequency of Osteoporosis and BMD Below the Expected Range for Age Among South Korean Women With Rheumatoid Arthritis. Int J Rheum Dis. 2012;15(3):289-96. PubMed PMID: 22709491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased frequency of osteoporosis and BMD below the expected range for age among South Korean women with rheumatoid arthritis. AU - Lee,Seung-Geun, AU - Park,Young-Eun, AU - Park,Sung-Hoo, AU - Kim,Tae-Kyun, AU - Choi,Hyun-Ju, AU - Lee,Seong-Jun, AU - Kim,Sung-Il, AU - Lee,Sun-Hee, AU - Kim,Geun-Tae, AU - Lee,Joung-Wook, AU - Lee,Jun-Hee, AU - Baek,Seung-Hoon, Y1 - 2012/04/12/ PY - 2012/6/20/entrez PY - 2012/6/20/pubmed PY - 2012/10/24/medline SP - 289 EP - 96 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 15 IS - 3 N2 - OBJECTIVE: To compare the frequency of osteoporosis and bone mineral density (BMD) below the expected range for age between female patients with rheumatoid arthritis (RA) and healthy subjects and to determine risk factors for bone loss in female patients with RA. METHOD: Two hundred and ninety-nine patients with RA and 246 age-matched healthy subjects were included in this study. BMD in the lumbar spine, femoral neck and total hip were measured with dual-energy X-ray absorptiometry. A T-score of -2.5 or lower in postmenopausal women was defined as osteoporosis, and a Z-score -2.0 or lower in females prior to menopause was defined as below the expected range for age. RESULT: The frequency of osteoporosis in the RA patients (22.1%) was significantly higher than in healthy subjects (11.4%) at either the spine or hip (P = 0.014). The occurrence of BMD below the expected range for age in RA patients (7.8%) was also significantly higher than in healthy subjects (1.0%, P = 0.015). In 299 female patients with RA, higher age, lower body mass index and postmenopausal status were significantly associated with the lumbar spine and hip BMD reduction. Of disease-related variables, glucocorticoid use was independently associated with reduction of hip BMD. CONCLUSION: The prevalence of osteoporosis in the RA patients was 1.9 times higher than in healthy subjects. Glucocorticoid use was a risk factor for generalized bone loss in female RA patients. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/22709491/Increased_frequency_of_osteoporosis_and_BMD_below_the_expected_range_for_age_among_South_Korean_women_with_rheumatoid_arthritis_ L2 - https://doi.org/10.1111/j.1756-185X.2012.01729.x DB - PRIME DP - Unbound Medicine ER -