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Factors affecting the likelihood of monkeypox's emergence and spread in the post-smallpox era.
Curr Opin Virol. 2012 Jun; 2(3):335-43.CO

Abstract

In 1980, the World Health Assembly announced that smallpox had been successfully eradicated as a disease of humans. The disease clinically and immunologically most similar to smallpox is monkeypox, a zoonosis endemic to moist forested regions in West and Central Africa. Smallpox vaccine provided protection against both infections. Monkeypox virus is a less efficient human pathogen than the agent of smallpox, but absent smallpox and the population-wide immunity engendered during eradication efforts, could monkeypox now gain a foothold in human communities? We discuss possible ecologic and epidemiologic limitations that could impede monkeypox's emergence as a significant pathogen of humans, and evaluate whether genetic constrains are sufficient to diminish monkeypox virus' capacity for enhanced specificity as a parasite of humans.

Authors+Show Affiliations

US Centers for Disease Control and Prevention, Poxvirus and Rabies Branch, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA. Nzr6@cdc.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22709519

Citation

Reynolds, Mary G., et al. "Factors Affecting the Likelihood of Monkeypox's Emergence and Spread in the Post-smallpox Era." Current Opinion in Virology, vol. 2, no. 3, 2012, pp. 335-43.
Reynolds MG, Carroll DS, Karem KL. Factors affecting the likelihood of monkeypox's emergence and spread in the post-smallpox era. Curr Opin Virol. 2012;2(3):335-43.
Reynolds, M. G., Carroll, D. S., & Karem, K. L. (2012). Factors affecting the likelihood of monkeypox's emergence and spread in the post-smallpox era. Current Opinion in Virology, 2(3), 335-43. https://doi.org/10.1016/j.coviro.2012.02.004
Reynolds MG, Carroll DS, Karem KL. Factors Affecting the Likelihood of Monkeypox's Emergence and Spread in the Post-smallpox Era. Curr Opin Virol. 2012;2(3):335-43. PubMed PMID: 22709519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors affecting the likelihood of monkeypox's emergence and spread in the post-smallpox era. AU - Reynolds,Mary G, AU - Carroll,Darin S, AU - Karem,Kevin L, Y1 - 2012/03/06/ PY - 2012/01/30/received PY - 2012/02/03/accepted PY - 2012/6/20/entrez PY - 2012/6/20/pubmed PY - 2012/10/10/medline SP - 335 EP - 43 JF - Current opinion in virology JO - Curr Opin Virol VL - 2 IS - 3 N2 - In 1980, the World Health Assembly announced that smallpox had been successfully eradicated as a disease of humans. The disease clinically and immunologically most similar to smallpox is monkeypox, a zoonosis endemic to moist forested regions in West and Central Africa. Smallpox vaccine provided protection against both infections. Monkeypox virus is a less efficient human pathogen than the agent of smallpox, but absent smallpox and the population-wide immunity engendered during eradication efforts, could monkeypox now gain a foothold in human communities? We discuss possible ecologic and epidemiologic limitations that could impede monkeypox's emergence as a significant pathogen of humans, and evaluate whether genetic constrains are sufficient to diminish monkeypox virus' capacity for enhanced specificity as a parasite of humans. SN - 1879-6265 UR - https://www.unboundmedicine.com/medline/citation/22709519/Factors_affecting_the_likelihood_of_monkeypox's_emergence_and_spread_in_the_post_smallpox_era_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1879-6257(12)00031-4 DB - PRIME DP - Unbound Medicine ER -