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Mediterranean diet and cognitive decline in women with cardiovascular disease or risk factors.

Abstract

BACKGROUND

Cardiovascular disease and vascular risk factors increase rates of cognitive impairment, but very little is known regarding prevention in this high-risk group. The heart-healthy Mediterranean-type dietary pattern may beneficially influence both vascular and cognitive outcomes.

OBJECTIVES

We examined the association between Mediterranean-style diet and cognitive decline in women with prevalent vascular disease or ≥3 coronary risk factors.

DESIGN/PARTICIPANTS/SETTING

Prospective cohort study among 2,504 women participants in the Women's Antioxidant Cardiovascular Study (WACS), a cohort of female health professionals. Adherence to a Mediterranean-style diet was determined at WACS baseline (1995-1996) using a 0- to 9-point scale with higher scores indicating higher adherence. In 1998-2000, participants aged ≥65 years underwent a telephone cognitive battery including five tests of global cognition, verbal memory, and category fluency. Tests were administered three additional times across 5.4 years.

STATISTICAL ANALYSES PERFORMED

We used multivariable-adjusted generalized linear models for repeated measures to compare the annual rates of cognitive score changes across tertiles of Mediterranean diet score, as assessed at WACS baseline.

RESULTS

In both basic- and multivariable-adjusted models, consuming a Mediterranean-style diet was not related to cognitive decline. No effect modification was detected by age, education, depression, cardiovascular disease severity at WACS baseline, or level of cognition at initial assessment.

CONCLUSIONS

In women at higher risk of cognitive decline due to vascular disease or risk factors, adherence to a Mediterranean-style diet was not associated with subsequent 5-year cognitive change.

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  • Authors+Show Affiliations

    ,

    Foundation for Public Health, Mutuelle Generale de l’Education Nationale (MGEN), Paris, France.

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    Source

    MeSH

    Aged
    Aged, 80 and over
    Cardiovascular Diseases
    Cognition Disorders
    Cohort Studies
    Diet, Mediterranean
    Female
    Fruit
    Humans
    Linear Models
    Mental Health
    Prospective Studies
    Risk Factors
    Vegetables
    Women's Health

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22709809

    Citation

    Vercambre, Marie-Noël, et al. "Mediterranean Diet and Cognitive Decline in Women With Cardiovascular Disease or Risk Factors." Journal of the Academy of Nutrition and Dietetics, vol. 112, no. 6, 2012, pp. 816-23.
    Vercambre MN, Grodstein F, Berr C, et al. Mediterranean diet and cognitive decline in women with cardiovascular disease or risk factors. J Acad Nutr Diet. 2012;112(6):816-23.
    Vercambre, M. N., Grodstein, F., Berr, C., & Kang, J. H. (2012). Mediterranean diet and cognitive decline in women with cardiovascular disease or risk factors. Journal of the Academy of Nutrition and Dietetics, 112(6), pp. 816-23. doi:10.1016/j.jand.2012.02.023.
    Vercambre MN, et al. Mediterranean Diet and Cognitive Decline in Women With Cardiovascular Disease or Risk Factors. J Acad Nutr Diet. 2012;112(6):816-23. PubMed PMID: 22709809.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mediterranean diet and cognitive decline in women with cardiovascular disease or risk factors. AU - Vercambre,Marie-Noël, AU - Grodstein,Francine, AU - Berr,Claudine, AU - Kang,Jae H, PY - 2011/10/24/received PY - 2012/02/22/accepted PY - 2012/6/20/entrez PY - 2012/6/20/pubmed PY - 2012/8/25/medline SP - 816 EP - 23 JF - Journal of the Academy of Nutrition and Dietetics JO - J Acad Nutr Diet VL - 112 IS - 6 N2 - BACKGROUND: Cardiovascular disease and vascular risk factors increase rates of cognitive impairment, but very little is known regarding prevention in this high-risk group. The heart-healthy Mediterranean-type dietary pattern may beneficially influence both vascular and cognitive outcomes. OBJECTIVES: We examined the association between Mediterranean-style diet and cognitive decline in women with prevalent vascular disease or ≥3 coronary risk factors. DESIGN/PARTICIPANTS/SETTING: Prospective cohort study among 2,504 women participants in the Women's Antioxidant Cardiovascular Study (WACS), a cohort of female health professionals. Adherence to a Mediterranean-style diet was determined at WACS baseline (1995-1996) using a 0- to 9-point scale with higher scores indicating higher adherence. In 1998-2000, participants aged ≥65 years underwent a telephone cognitive battery including five tests of global cognition, verbal memory, and category fluency. Tests were administered three additional times across 5.4 years. STATISTICAL ANALYSES PERFORMED: We used multivariable-adjusted generalized linear models for repeated measures to compare the annual rates of cognitive score changes across tertiles of Mediterranean diet score, as assessed at WACS baseline. RESULTS: In both basic- and multivariable-adjusted models, consuming a Mediterranean-style diet was not related to cognitive decline. No effect modification was detected by age, education, depression, cardiovascular disease severity at WACS baseline, or level of cognition at initial assessment. CONCLUSIONS: In women at higher risk of cognitive decline due to vascular disease or risk factors, adherence to a Mediterranean-style diet was not associated with subsequent 5-year cognitive change. SN - 2212-2672 UR - https://www.unboundmedicine.com/medline/citation/22709809/Mediterranean_diet_and_cognitive_decline_in_women_with_cardiovascular_disease_or_risk_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-2672(12)00290-0 DB - PRIME DP - Unbound Medicine ER -