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Solar ultraviolet radiation induces biological alterations in human skin in vitro: relevance of a well-balanced UVA/UVB protection.
Indian J Dermatol Venereol Leprol. 2012 Jun; 78 Suppl 1:S15-23.IJ

Abstract

Cutaneous damages such as sunburn, pigmentation, and photoaging are known to be induced by acute as well as repetitive sun exposure. Not only for basic research, but also for the design of the most efficient photoprotection, it is crucial to understand and identify the early biological events occurring after ultraviolet (UV) exposure. Reconstructed human skin models provide excellent and reliable in vitro tools to study the UV-induced alterations of the different skin cell types, keratinocytes, fibroblasts, and melanocytes in a dose- and time-dependent manner. Using different in vitro human skin models, the effects of UV light (UVB and UVA) were investigated. UVB-induced damages are essentially epidermal, with the typical sunburn cells and DNA lesions, whereas UVA radiation-induced damages are mostly located within the dermal compartment. Pigmentation can also be obtained after solar simulated radiation exposure of pigmented reconstructed skin model. Those models are also highly adequate to assess the potential of sunscreens to protect the skin from UV-associated damage, sunburn reaction, photoaging, and pigmentation. The results showed that an effective photoprotection is provided by broad-spectrum sunscreens with a potent absorption in both UVB and UVA ranges.

Authors+Show Affiliations

L'Oréal Research and Innovation, Clichy, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22710109

Citation

Bernerd, Francoise, et al. "Solar Ultraviolet Radiation Induces Biological Alterations in Human Skin in Vitro: Relevance of a Well-balanced UVA/UVB Protection." Indian Journal of Dermatology, Venereology and Leprology, vol. 78 Suppl 1, 2012, pp. S15-23.
Bernerd F, Marionnet C, Duval C. Solar ultraviolet radiation induces biological alterations in human skin in vitro: relevance of a well-balanced UVA/UVB protection. Indian J Dermatol Venereol Leprol. 2012;78 Suppl 1:S15-23.
Bernerd, F., Marionnet, C., & Duval, C. (2012). Solar ultraviolet radiation induces biological alterations in human skin in vitro: relevance of a well-balanced UVA/UVB protection. Indian Journal of Dermatology, Venereology and Leprology, 78 Suppl 1, S15-23. https://doi.org/10.4103/0378-6323.97351
Bernerd F, Marionnet C, Duval C. Solar Ultraviolet Radiation Induces Biological Alterations in Human Skin in Vitro: Relevance of a Well-balanced UVA/UVB Protection. Indian J Dermatol Venereol Leprol. 2012;78 Suppl 1:S15-23. PubMed PMID: 22710109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solar ultraviolet radiation induces biological alterations in human skin in vitro: relevance of a well-balanced UVA/UVB protection. AU - Bernerd,Francoise, AU - Marionnet,Claire, AU - Duval,Christine, PY - 2012/6/20/entrez PY - 2012/6/22/pubmed PY - 2012/10/17/medline SP - S15 EP - 23 JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol VL - 78 Suppl 1 N2 - Cutaneous damages such as sunburn, pigmentation, and photoaging are known to be induced by acute as well as repetitive sun exposure. Not only for basic research, but also for the design of the most efficient photoprotection, it is crucial to understand and identify the early biological events occurring after ultraviolet (UV) exposure. Reconstructed human skin models provide excellent and reliable in vitro tools to study the UV-induced alterations of the different skin cell types, keratinocytes, fibroblasts, and melanocytes in a dose- and time-dependent manner. Using different in vitro human skin models, the effects of UV light (UVB and UVA) were investigated. UVB-induced damages are essentially epidermal, with the typical sunburn cells and DNA lesions, whereas UVA radiation-induced damages are mostly located within the dermal compartment. Pigmentation can also be obtained after solar simulated radiation exposure of pigmented reconstructed skin model. Those models are also highly adequate to assess the potential of sunscreens to protect the skin from UV-associated damage, sunburn reaction, photoaging, and pigmentation. The results showed that an effective photoprotection is provided by broad-spectrum sunscreens with a potent absorption in both UVB and UVA ranges. SN - 0973-3922 UR - https://www.unboundmedicine.com/medline/citation/22710109/Solar_ultraviolet_radiation_induces_biological_alterations_in_human_skin_in_vitro:_relevance_of_a_well_balanced_UVA/UVB_protection_ L2 - http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=7;spage=15;epage=23;aulast=Bernerd DB - PRIME DP - Unbound Medicine ER -