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Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany.

Abstract

Oxidative stress is believed to play a central role in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disease. Antioxidants may prevent the onset AD as high dietary intake of vitamin C and E were reported to be associated with lower risk of the disease. The objective of this study was to evaluate the serum levels of antioxidants in persons with mild dementia to test whether it is associated with lower levels of antioxidants in a cross-sectional study in the population of the "Activity and Function in the Ederly in Ulm" (ActiFE) study. Main exposure measures were vitamin C, vitamin E, β-carotene, lycopene, and coenzyme Q10 as analyzed by HPLC. Main outcome measures were mild cognitive impairment among 74 mildly demented compared to 158 age- and gender-matched controls. We found that blood vitamin C and β-carotene concentrations were significantly lower in demented than in control persons even after adjusting for school education, intake of dietary supplements, smoking habits, body mass index, and alcohol consumption (3rd versus 1st tertile: OR: 0.29, 95% CI, 0.09-0.96 and 0.13, 95% CI, 0.03-0.55, respectively). No associations were found for vitamin E, lycopene, and coenzyme Q10. Our findings suggest an association of vitamin C and β-carotene with dementia. However this is limited to the cross-sectional character of our study and longitudinal data will give further insight into this association.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Ulm University, Ulm, Germany.

    , , , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Antioxidants
    Ascorbic Acid
    Biomarkers
    Carotenoids
    Case-Control Studies
    Cross-Sectional Studies
    Dementia
    Dietary Supplements
    Female
    Germany
    Humans
    Male
    Population Surveillance
    beta Carotene

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22710913

    Citation

    von Arnim, Christine A F., et al. "Dietary Antioxidants and Dementia in a Population-based Case-control Study Among Older People in South Germany." Journal of Alzheimer's Disease : JAD, vol. 31, no. 4, 2012, pp. 717-24.
    von Arnim CA, Herbolsheimer F, Nikolaus T, et al. Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany. J Alzheimers Dis. 2012;31(4):717-24.
    von Arnim, C. A., Herbolsheimer, F., Nikolaus, T., Peter, R., Biesalski, H. K., Ludolph, A. C., ... Nagel, G. (2012). Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany. Journal of Alzheimer's Disease : JAD, 31(4), pp. 717-24. doi:10.3233/JAD-2012-120634.
    von Arnim CA, et al. Dietary Antioxidants and Dementia in a Population-based Case-control Study Among Older People in South Germany. J Alzheimers Dis. 2012;31(4):717-24. PubMed PMID: 22710913.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany. AU - von Arnim,Christine A F, AU - Herbolsheimer,Florian, AU - Nikolaus,Thorsten, AU - Peter,Richard, AU - Biesalski,Hans K, AU - Ludolph,Albert C, AU - Riepe,Matthias, AU - Nagel,Gabriele, AU - ,, PY - 2012/6/20/entrez PY - 2012/6/20/pubmed PY - 2013/7/9/medline SP - 717 EP - 24 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 31 IS - 4 N2 - Oxidative stress is believed to play a central role in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disease. Antioxidants may prevent the onset AD as high dietary intake of vitamin C and E were reported to be associated with lower risk of the disease. The objective of this study was to evaluate the serum levels of antioxidants in persons with mild dementia to test whether it is associated with lower levels of antioxidants in a cross-sectional study in the population of the "Activity and Function in the Ederly in Ulm" (ActiFE) study. Main exposure measures were vitamin C, vitamin E, β-carotene, lycopene, and coenzyme Q10 as analyzed by HPLC. Main outcome measures were mild cognitive impairment among 74 mildly demented compared to 158 age- and gender-matched controls. We found that blood vitamin C and β-carotene concentrations were significantly lower in demented than in control persons even after adjusting for school education, intake of dietary supplements, smoking habits, body mass index, and alcohol consumption (3rd versus 1st tertile: OR: 0.29, 95% CI, 0.09-0.96 and 0.13, 95% CI, 0.03-0.55, respectively). No associations were found for vitamin E, lycopene, and coenzyme Q10. Our findings suggest an association of vitamin C and β-carotene with dementia. However this is limited to the cross-sectional character of our study and longitudinal data will give further insight into this association. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/22710913/Dietary_antioxidants_and_dementia_in_a_population_based_case_control_study_among_older_people_in_South_Germany_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2012-120634 DB - PRIME DP - Unbound Medicine ER -