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Wheat flour fortification with folic acid: changes in neural tube defects rates in Chile.
. 2012 Aug; 158A(8):1885-90.

Abstract

In January 2000, Chilean Ministry of Health mandated the addition of folic acid (FA) to wheat flour in order to reduce the risk of neural tube defects (NTDs). This policy resulted in significant increases in serum and red cell folate in women of fertile age 1 year after fortification. To evaluate the effect of wheat flour fortification on the prevalence of NTDs in Chile we designed a prospective hospital-based surveillance program to monitor the frequency of NTDs in all births (live and stillbirths) with birth weight≥500 g at the nine public maternity hospitals of Santiago, Chile from 1999 to 2009. During the pre-fortification period (1999-2000) the NTD rate was 17.1/10,000 births in a total of 120,566 newborns. During the post-fortification period (2001-2009) the NTD rate decreased to 8.6/10,000 births in a total of 489,915 newborns, which translates into a rate reduction of 50% (RR: 0.5; 95% CI: 0.42-0.59) for all NTDs. The rate reduction by type of NTD studied was: 50% in anencephaly (RR: 0.5; 95% CI: 0.38-0.67), 42% in cephalocele (RR: 0.58; 95% CI: 0.37-0.89), and 52% in spina bifida (RR: 0.48; 95% CI: 0.38-0.6). Rates showed significant reduction both in stillbirths and live births: 510.3 to 183.6/10,000 (RR=0.36; 95% CI: 0.25-0.53) and 13.3 to 7.5/10,000 (RR=0.56; 95% CI: 0.47-0.68), respectively. In Chile, fortification of wheat flour with FA has proven to be an effective strategy for the primary prevention of NTDs.

Authors+Show Affiliations

Institute of Nutrition and Food Technology (INTA), University of Chile, and Genetic Unit, Hospital Clínico Universidad de Chile, Genetics Center, Clínica Las Condes, Chile. fcortes@clc.clNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22711368

Citation

Cortés, Fanny, et al. "Wheat Flour Fortification With Folic Acid: Changes in Neural Tube Defects Rates in Chile." American Journal of Medical Genetics. Part A, vol. 158A, no. 8, 2012, pp. 1885-90.
Cortés F, Mellado C, Pardo RA, et al. Wheat flour fortification with folic acid: changes in neural tube defects rates in Chile. Am J Med Genet A. 2012;158A(8):1885-90.
Cortés, F., Mellado, C., Pardo, R. A., Villarroel, L. A., & Hertrampf, E. (2012). Wheat flour fortification with folic acid: changes in neural tube defects rates in Chile. American Journal of Medical Genetics. Part A, 158A(8), 1885-90. https://doi.org/10.1002/ajmg.a.35430
Cortés F, et al. Wheat Flour Fortification With Folic Acid: Changes in Neural Tube Defects Rates in Chile. Am J Med Genet A. 2012;158A(8):1885-90. PubMed PMID: 22711368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wheat flour fortification with folic acid: changes in neural tube defects rates in Chile. AU - Cortés,Fanny, AU - Mellado,C, AU - Pardo,R A, AU - Villarroel,L A, AU - Hertrampf,E, Y1 - 2012/06/18/ PY - 2011/09/13/received PY - 2012/03/26/accepted PY - 2012/6/20/entrez PY - 2012/6/20/pubmed PY - 2012/11/6/medline SP - 1885 EP - 90 JF - American journal of medical genetics. Part A JO - Am. J. Med. Genet. A VL - 158A IS - 8 N2 - In January 2000, Chilean Ministry of Health mandated the addition of folic acid (FA) to wheat flour in order to reduce the risk of neural tube defects (NTDs). This policy resulted in significant increases in serum and red cell folate in women of fertile age 1 year after fortification. To evaluate the effect of wheat flour fortification on the prevalence of NTDs in Chile we designed a prospective hospital-based surveillance program to monitor the frequency of NTDs in all births (live and stillbirths) with birth weight≥500 g at the nine public maternity hospitals of Santiago, Chile from 1999 to 2009. During the pre-fortification period (1999-2000) the NTD rate was 17.1/10,000 births in a total of 120,566 newborns. During the post-fortification period (2001-2009) the NTD rate decreased to 8.6/10,000 births in a total of 489,915 newborns, which translates into a rate reduction of 50% (RR: 0.5; 95% CI: 0.42-0.59) for all NTDs. The rate reduction by type of NTD studied was: 50% in anencephaly (RR: 0.5; 95% CI: 0.38-0.67), 42% in cephalocele (RR: 0.58; 95% CI: 0.37-0.89), and 52% in spina bifida (RR: 0.48; 95% CI: 0.38-0.6). Rates showed significant reduction both in stillbirths and live births: 510.3 to 183.6/10,000 (RR=0.36; 95% CI: 0.25-0.53) and 13.3 to 7.5/10,000 (RR=0.56; 95% CI: 0.47-0.68), respectively. In Chile, fortification of wheat flour with FA has proven to be an effective strategy for the primary prevention of NTDs. SN - 1552-4833 UR - https://www.unboundmedicine.com/medline/citation/22711368/Wheat_flour_fortification_with_folic_acid:_changes_in_neural_tube_defects_rates_in_Chile_ L2 - https://doi.org/10.1002/ajmg.a.35430 DB - PRIME DP - Unbound Medicine ER -