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Urinary estrogen metabolites in two soy trials with premenopausal women.
Eur J Clin Nutr 2012; 66(9):1044-9EJ

Abstract

BACKGROUND

Soy consumption may protect against breast cancer through modification of estrogen metabolism.

OBJECTIVES

We examined the effect of soy foods on urinary estrogens and the 2-hydroxy (OH)/16α-OH estrone (E(1)) ratio in two dietary interventions with premenopausal women.

SUBJECTS/METHODS

The Breast, Estrogens, And Nutrition (BEAN1) study was a 2-year randomized trial and BEAN2 a 13-month randomized crossover study. In both interventions, study participants consumed a high-soy diet with 2 soy food servings/day and a low-soy diet with <3 servings of soy/week. Urine samples were collected at baseline and at the end of the diet periods, analyzed for nine estrogen metabolites by liquid chromatography mass spectrometry, and adjusted for creatinine levels. For BEAN1, two samples for 188 participants and for BEAN2, three samples for 79 women were analyzed. We applied mixed-effects regression models with log-transformed values of estrogen metabolites and soy intake as the exposure variable.

RESULTS

In BEAN1, no effect of the high-soy diet on individual estrogen metabolites or hydroxylation pathways was observed. The median 2-OH/16α-OHE(1) ratio decreased non-significantly in the intervention group from 6.2 to 5.2 as compared with 6.8 and 7.2 in the control group (P=0.63). In BEAN2, only 4-OHE(1) was significantly lower after the high-soy diet. Interaction terms of the high-soy diet with equol producer status, ethnicity and weight status revealed no significant effect modification.

CONCLUSIONS

Contrary to our hypothesis and some previous reports, the results from two well-controlled dietary interventions do not support an effect of a high-soy diet on a panel of urinary estrogen metabolites and the 2-OH/16α-OHE(1) ratio.

Authors+Show Affiliations

University of Hawaii Cancer Center, Honolulu, HI 96813, USA. gertraud@cc.hawaii.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22713773

Citation

Maskarinec, G, et al. "Urinary Estrogen Metabolites in Two Soy Trials With Premenopausal Women." European Journal of Clinical Nutrition, vol. 66, no. 9, 2012, pp. 1044-9.
Maskarinec G, Morimoto Y, Heak S, et al. Urinary estrogen metabolites in two soy trials with premenopausal women. Eur J Clin Nutr. 2012;66(9):1044-9.
Maskarinec, G., Morimoto, Y., Heak, S., Isaki, M., Steinbrecher, A., Custer, L., & Franke, A. A. (2012). Urinary estrogen metabolites in two soy trials with premenopausal women. European Journal of Clinical Nutrition, 66(9), pp. 1044-9. doi:10.1038/ejcn.2012.71.
Maskarinec G, et al. Urinary Estrogen Metabolites in Two Soy Trials With Premenopausal Women. Eur J Clin Nutr. 2012;66(9):1044-9. PubMed PMID: 22713773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary estrogen metabolites in two soy trials with premenopausal women. AU - Maskarinec,G, AU - Morimoto,Y, AU - Heak,S, AU - Isaki,M, AU - Steinbrecher,A, AU - Custer,L, AU - Franke,A A, Y1 - 2012/06/20/ PY - 2012/6/21/entrez PY - 2012/6/21/pubmed PY - 2013/4/20/medline SP - 1044 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 9 N2 - BACKGROUND: Soy consumption may protect against breast cancer through modification of estrogen metabolism. OBJECTIVES: We examined the effect of soy foods on urinary estrogens and the 2-hydroxy (OH)/16α-OH estrone (E(1)) ratio in two dietary interventions with premenopausal women. SUBJECTS/METHODS: The Breast, Estrogens, And Nutrition (BEAN1) study was a 2-year randomized trial and BEAN2 a 13-month randomized crossover study. In both interventions, study participants consumed a high-soy diet with 2 soy food servings/day and a low-soy diet with <3 servings of soy/week. Urine samples were collected at baseline and at the end of the diet periods, analyzed for nine estrogen metabolites by liquid chromatography mass spectrometry, and adjusted for creatinine levels. For BEAN1, two samples for 188 participants and for BEAN2, three samples for 79 women were analyzed. We applied mixed-effects regression models with log-transformed values of estrogen metabolites and soy intake as the exposure variable. RESULTS: In BEAN1, no effect of the high-soy diet on individual estrogen metabolites or hydroxylation pathways was observed. The median 2-OH/16α-OHE(1) ratio decreased non-significantly in the intervention group from 6.2 to 5.2 as compared with 6.8 and 7.2 in the control group (P=0.63). In BEAN2, only 4-OHE(1) was significantly lower after the high-soy diet. Interaction terms of the high-soy diet with equol producer status, ethnicity and weight status revealed no significant effect modification. CONCLUSIONS: Contrary to our hypothesis and some previous reports, the results from two well-controlled dietary interventions do not support an effect of a high-soy diet on a panel of urinary estrogen metabolites and the 2-OH/16α-OHE(1) ratio. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/22713773/Urinary_estrogen_metabolites_in_two_soy_trials_with_premenopausal_women_ L2 - http://dx.doi.org/10.1038/ejcn.2012.71 DB - PRIME DP - Unbound Medicine ER -