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Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women.
Mov Disord. 2012 Jul; 27(8):980-7.MD

Abstract

Addictive behaviors, such as cigarette smoking and coffee drinking, have been associated with a reduced risk of Parkinson's disease (PD). Whether alcohol consumption is also associated with PD risk is less certain. We prospectively followed 132,403 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Alcohol intake was assessed at baseline. Incident cases of PD (n = 605; 389 male and 216 female) were confirmed by treating physicians and medical record review. Relative risks (RRs) were estimated using proportional hazards models, adjusting for age, smoking, and other risk factors. Alcohol consumption was not significantly associated with PD risk. After adjustment for age, smoking, and other risk factors, the RR comparing men consuming 30 or more grams of alcohol per day (highest category) to nondrinker men was 1.29 (95% confidence interval [CI]: 0.90, 1.86; P trend: 0.40), and the RR comparing women consuming 15 or more grams of alcohol (highest category) per day to nondrinker women was 0.77 (95% CI: 0.41, 1.45; P trend: 0.87). Consumption of beer, wine, or liquor was also not associated with PD risk. The results of this large, prospective study do not support an association between alcohol intake and risk of PD.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA. palacios@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22714720

Citation

Palacios, Natalia, et al. "Alcohol and Risk of Parkinson's Disease in a Large, Prospective Cohort of Men and Women." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 27, no. 8, 2012, pp. 980-7.
Palacios N, Gao X, O'Reilly E, et al. Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women. Mov Disord. 2012;27(8):980-7.
Palacios, N., Gao, X., O'Reilly, E., Schwarzschild, M., McCullough, M. L., Mayo, T., Gapstur, S. M., & Ascherio, A. A. (2012). Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women. Movement Disorders : Official Journal of the Movement Disorder Society, 27(8), 980-7. https://doi.org/10.1002/mds.25050
Palacios N, et al. Alcohol and Risk of Parkinson's Disease in a Large, Prospective Cohort of Men and Women. Mov Disord. 2012;27(8):980-7. PubMed PMID: 22714720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women. AU - Palacios,Natalia, AU - Gao,Xiang, AU - O'Reilly,Eilis, AU - Schwarzschild,Michael, AU - McCullough,Marjorie L, AU - Mayo,Tinisha, AU - Gapstur,Susan M, AU - Ascherio,Alberto A, Y1 - 2012/06/19/ PY - 2011/09/27/received PY - 2012/03/23/revised PY - 2012/04/20/accepted PY - 2012/6/21/entrez PY - 2012/6/21/pubmed PY - 2012/12/10/medline SP - 980 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 27 IS - 8 N2 - Addictive behaviors, such as cigarette smoking and coffee drinking, have been associated with a reduced risk of Parkinson's disease (PD). Whether alcohol consumption is also associated with PD risk is less certain. We prospectively followed 132,403 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Alcohol intake was assessed at baseline. Incident cases of PD (n = 605; 389 male and 216 female) were confirmed by treating physicians and medical record review. Relative risks (RRs) were estimated using proportional hazards models, adjusting for age, smoking, and other risk factors. Alcohol consumption was not significantly associated with PD risk. After adjustment for age, smoking, and other risk factors, the RR comparing men consuming 30 or more grams of alcohol per day (highest category) to nondrinker men was 1.29 (95% confidence interval [CI]: 0.90, 1.86; P trend: 0.40), and the RR comparing women consuming 15 or more grams of alcohol (highest category) per day to nondrinker women was 0.77 (95% CI: 0.41, 1.45; P trend: 0.87). Consumption of beer, wine, or liquor was also not associated with PD risk. The results of this large, prospective study do not support an association between alcohol intake and risk of PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/22714720/Alcohol_and_risk_of_Parkinson's_disease_in_a_large_prospective_cohort_of_men_and_women_ L2 - https://doi.org/10.1002/mds.25050 DB - PRIME DP - Unbound Medicine ER -