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Dietary intakes of retinol, carotenes, vitamin C, and vitamin E and colorectal cancer risk: the Fukuoka colorectal cancer study.
Nutr Cancer 2012; 64(6):798-805NC

Abstract

It has long been a matter of interest whether antioxidant vitamins are protective against colorectal cancer as well as human cancers in general, but epidemiological evidence is inconclusive. We investigated associations of dietary intakes of retinol and antioxidant vitamins with colorectal cancer risk in 816 incident cases of histologically confirmed colorectal cancer and 815 controls randomly selected for the Fukuoka colorectal cancer study in Japan. Dietary intakes were assessed by a PC-assisted interview regarding 148 food items. Statistical adjustment was made for body mass index, physical activity, calcium, and n-3 fatty acid intake and other factors. Retinol intake was significantly, inversely associated with colorectal cancer risk; the odds ratio for the highest vs. lowest was 0.55 (95% CI: 0.35, 0.88; P (trend) = 0.01) in women, but a modest increase in the risk was observed among men with the highest intake of retinol. Liver was the major source of retinol intake and showed similar associations with colorectal cancer risk in men and women. Intake of carotenes, vitamin C, and vitamin E were not related to colorectal cancer risk in either men or women. The study did not support a hypothesis that dietary intake of antioxidant vitamins is protective in the development of colorectal cancer.

Authors+Show Affiliations

Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. wangzj@phealth.med.kyushu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22716281

Citation

Wang, Zhenjie, et al. "Dietary Intakes of Retinol, Carotenes, Vitamin C, and Vitamin E and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study." Nutrition and Cancer, vol. 64, no. 6, 2012, pp. 798-805.
Wang Z, Joshi AM, Ohnaka K, et al. Dietary intakes of retinol, carotenes, vitamin C, and vitamin E and colorectal cancer risk: the Fukuoka colorectal cancer study. Nutr Cancer. 2012;64(6):798-805.
Wang, Z., Joshi, A. M., Ohnaka, K., Morita, M., Toyomura, K., Kono, S., ... Terasaka, R. (2012). Dietary intakes of retinol, carotenes, vitamin C, and vitamin E and colorectal cancer risk: the Fukuoka colorectal cancer study. Nutrition and Cancer, 64(6), pp. 798-805. doi:10.1080/01635581.2012.690927.
Wang Z, et al. Dietary Intakes of Retinol, Carotenes, Vitamin C, and Vitamin E and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study. Nutr Cancer. 2012;64(6):798-805. PubMed PMID: 22716281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intakes of retinol, carotenes, vitamin C, and vitamin E and colorectal cancer risk: the Fukuoka colorectal cancer study. AU - Wang,Zhenjie, AU - Joshi,Amit Man, AU - Ohnaka,Keizo, AU - Morita,Makiko, AU - Toyomura,Kengo, AU - Kono,Suminori, AU - Ueki,Takashi, AU - Tanaka,Masao, AU - Kakeji,Yoshihiro, AU - Maehara,Yoshihiko, AU - Okamura,Takeshi, AU - Ikejiri,Koji, AU - Futami,Kitaroh, AU - Maekawa,Takafumi, AU - Yasunami,Yohichi, AU - Takenaka,Kenji, AU - Ichimiya,Hitoshi, AU - Terasaka,Reiji, Y1 - 2012/06/20/ PY - 2012/6/22/entrez PY - 2012/6/22/pubmed PY - 2013/2/5/medline SP - 798 EP - 805 JF - Nutrition and cancer JO - Nutr Cancer VL - 64 IS - 6 N2 - It has long been a matter of interest whether antioxidant vitamins are protective against colorectal cancer as well as human cancers in general, but epidemiological evidence is inconclusive. We investigated associations of dietary intakes of retinol and antioxidant vitamins with colorectal cancer risk in 816 incident cases of histologically confirmed colorectal cancer and 815 controls randomly selected for the Fukuoka colorectal cancer study in Japan. Dietary intakes were assessed by a PC-assisted interview regarding 148 food items. Statistical adjustment was made for body mass index, physical activity, calcium, and n-3 fatty acid intake and other factors. Retinol intake was significantly, inversely associated with colorectal cancer risk; the odds ratio for the highest vs. lowest was 0.55 (95% CI: 0.35, 0.88; P (trend) = 0.01) in women, but a modest increase in the risk was observed among men with the highest intake of retinol. Liver was the major source of retinol intake and showed similar associations with colorectal cancer risk in men and women. Intake of carotenes, vitamin C, and vitamin E were not related to colorectal cancer risk in either men or women. The study did not support a hypothesis that dietary intake of antioxidant vitamins is protective in the development of colorectal cancer. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/22716281/Dietary_intakes_of_retinol_carotenes_vitamin_C_and_vitamin_E_and_colorectal_cancer_risk:_the_Fukuoka_colorectal_cancer_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2012.690927 DB - PRIME DP - Unbound Medicine ER -