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Nigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeys.
Clin Neuropharmacol. 1990 Oct; 13(5):448-58.CN

Abstract

We examined the ability of L-DOPA to induce dyskinesias in MPTP-treated and normal squirrel monkeys to establish whether the underlying neuropathology associated with parkinsonism is an absolute requirement or merely promotes the development of drug-induced dyskinesias. Administration of L-DOPA (5-40 mg/kg p.o., following a 60 min pretreatment with carbidopa 2.5-20 mg/kg p.o.) induced a range of dopamine-mediated behaviours including locomotor activity, stereotyped scratching, and climbing in both lesioned and nonlesioned animals. However, the dose-response curves showed a marked (three- to fourfold) shift to the left in lesioned animals, indicating behavioural supersensitivity. In contrast, L-DOPA-induced dyskinesias were only observed in MPTP-treated monkeys. Doses required for induction of dyskinesias were lower than those required to induce climbing. These findings provide further evidence that nigrostriatal damage is essential for the genesis of L-DOPA-induced dyskinesias.

Authors+Show Affiliations

Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Essex, U.K.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2272024

Citation

Boyce, S, et al. "Nigrostriatal Damage Is Required for Induction of Dyskinesias By L-DOPA in Squirrel Monkeys." Clinical Neuropharmacology, vol. 13, no. 5, 1990, pp. 448-58.
Boyce S, Rupniak NM, Steventon MJ, et al. Nigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeys. Clin Neuropharmacol. 1990;13(5):448-58.
Boyce, S., Rupniak, N. M., Steventon, M. J., & Iversen, S. D. (1990). Nigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeys. Clinical Neuropharmacology, 13(5), 448-58.
Boyce S, et al. Nigrostriatal Damage Is Required for Induction of Dyskinesias By L-DOPA in Squirrel Monkeys. Clin Neuropharmacol. 1990;13(5):448-58. PubMed PMID: 2272024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeys. AU - Boyce,S, AU - Rupniak,N M, AU - Steventon,M J, AU - Iversen,S D, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 448 EP - 58 JF - Clinical neuropharmacology JO - Clin Neuropharmacol VL - 13 IS - 5 N2 - We examined the ability of L-DOPA to induce dyskinesias in MPTP-treated and normal squirrel monkeys to establish whether the underlying neuropathology associated with parkinsonism is an absolute requirement or merely promotes the development of drug-induced dyskinesias. Administration of L-DOPA (5-40 mg/kg p.o., following a 60 min pretreatment with carbidopa 2.5-20 mg/kg p.o.) induced a range of dopamine-mediated behaviours including locomotor activity, stereotyped scratching, and climbing in both lesioned and nonlesioned animals. However, the dose-response curves showed a marked (three- to fourfold) shift to the left in lesioned animals, indicating behavioural supersensitivity. In contrast, L-DOPA-induced dyskinesias were only observed in MPTP-treated monkeys. Doses required for induction of dyskinesias were lower than those required to induce climbing. These findings provide further evidence that nigrostriatal damage is essential for the genesis of L-DOPA-induced dyskinesias. SN - 0362-5664 UR - https://www.unboundmedicine.com/medline/citation/2272024/Nigrostriatal_damage_is_required_for_induction_of_dyskinesias_by_L_DOPA_in_squirrel_monkeys_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2272024.ui DB - PRIME DP - Unbound Medicine ER -