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Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice.
J Infect Dis. 2012 Sep 01; 206(5):744-51.JI

Abstract

BACKGROUND

Entamoeba moshkovskii is prevalent in developing countries and morphologically indistinguishable from pathogenic Entamoeba histolytica and nonpathogenic Entamoeba dispar. It is not known if E. moshkovskii is pathogenic.

METHODS

Mice were intracecally challenged with the trophozoites of each Entamoeba spp. to test the ability to cause diarrhea, and infants in Bangladesh were prospectively observed to see if newly acquired E. moshkovskii infection was associated with diarrhea.

RESULTS

E. moshkovskii and E. histolytica caused diarrhea and weight loss in susceptible mice. E. dispar infected none of the mouse strains tested. In Mirpur, Dhaka, Bangladesh, E. moshkovskii, E. histolytica, and E. dispar were identified in 42 (2.95%), 66 (4.63%), and 5 (0.35%), respectively, of 1426 diarrheal episodes in 385 children followed prospectively from birth to one year of age. Diarrhea occurred temporally with acquisition of a new E. moshkovskii infection: in the 2 months preceding E. moshkvskii-associated diarrhea, 86% (36 of 42) of monthly surveillance stool samples were negative for E. moshkovskii.

CONCLUSIONS

E. moshkovskii was found to be pathogenic in mice. In children, the acquisition of E. moshkovskii infection was associated with diarrhea. These data are consistent with E. moshkovskii causing disease, indicating that it is important to reexamine its pathogenicity.

Authors+Show Affiliations

Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22723640

Citation

Shimokawa, Chikako, et al. "Entamoeba Moshkovskii Is Associated With Diarrhea in Infants and Causes Diarrhea and Colitis in Mice." The Journal of Infectious Diseases, vol. 206, no. 5, 2012, pp. 744-51.
Shimokawa C, Kabir M, Taniuchi M, et al. Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice. J Infect Dis. 2012;206(5):744-51.
Shimokawa, C., Kabir, M., Taniuchi, M., Mondal, D., Kobayashi, S., Ali, I. K., Sobuz, S. U., Senba, M., Houpt, E., Haque, R., Petri, W. A., & Hamano, S. (2012). Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice. The Journal of Infectious Diseases, 206(5), 744-51. https://doi.org/10.1093/infdis/jis414
Shimokawa C, et al. Entamoeba Moshkovskii Is Associated With Diarrhea in Infants and Causes Diarrhea and Colitis in Mice. J Infect Dis. 2012 Sep 1;206(5):744-51. PubMed PMID: 22723640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice. AU - Shimokawa,Chikako, AU - Kabir,Mamun, AU - Taniuchi,Mami, AU - Mondal,Dinesh, AU - Kobayashi,Seiki, AU - Ali,Ibne Karim M, AU - Sobuz,Shihab U, AU - Senba,Masachika, AU - Houpt,Eric, AU - Haque,Rashidul, AU - Petri,William A,Jr AU - Hamano,Shinjiro, Y1 - 2012/06/21/ PY - 2012/6/23/entrez PY - 2012/6/23/pubmed PY - 2013/1/9/medline SP - 744 EP - 51 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 206 IS - 5 N2 - BACKGROUND: Entamoeba moshkovskii is prevalent in developing countries and morphologically indistinguishable from pathogenic Entamoeba histolytica and nonpathogenic Entamoeba dispar. It is not known if E. moshkovskii is pathogenic. METHODS: Mice were intracecally challenged with the trophozoites of each Entamoeba spp. to test the ability to cause diarrhea, and infants in Bangladesh were prospectively observed to see if newly acquired E. moshkovskii infection was associated with diarrhea. RESULTS: E. moshkovskii and E. histolytica caused diarrhea and weight loss in susceptible mice. E. dispar infected none of the mouse strains tested. In Mirpur, Dhaka, Bangladesh, E. moshkovskii, E. histolytica, and E. dispar were identified in 42 (2.95%), 66 (4.63%), and 5 (0.35%), respectively, of 1426 diarrheal episodes in 385 children followed prospectively from birth to one year of age. Diarrhea occurred temporally with acquisition of a new E. moshkovskii infection: in the 2 months preceding E. moshkvskii-associated diarrhea, 86% (36 of 42) of monthly surveillance stool samples were negative for E. moshkovskii. CONCLUSIONS: E. moshkovskii was found to be pathogenic in mice. In children, the acquisition of E. moshkovskii infection was associated with diarrhea. These data are consistent with E. moshkovskii causing disease, indicating that it is important to reexamine its pathogenicity. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/22723640/full_citation L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jis414 DB - PRIME DP - Unbound Medicine ER -