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Rethinking inflammation: neural circuits in the regulation of immunity.
Immunol Rev. 2012 Jul; 248(1):188-204.IR

Abstract

Neural reflex circuits regulate cytokine release to prevent potentially damaging inflammation and maintain homeostasis. In the inflammatory reflex, sensory input elicited by infection or injury travels through the afferent vagus nerve to integrative regions in the brainstem, and efferent nerves carry outbound signals that terminate in the spleen and other tissues. Neurotransmitters from peripheral autonomic nerves subsequently promote acetylcholine-release from a subset of CD4(+) T cells that relay the neural signal to other immune cells, e.g. through activation of α7 nicotinic acetylcholine receptors on macrophages. Here, we review recent progress in the understanding of the inflammatory reflex and discuss potential therapeutic implications of current findings in this evolving field.

Authors+Show Affiliations

Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22725962

Citation

Olofsson, Peder S., et al. "Rethinking Inflammation: Neural Circuits in the Regulation of Immunity." Immunological Reviews, vol. 248, no. 1, 2012, pp. 188-204.
Olofsson PS, Rosas-Ballina M, Levine YA, et al. Rethinking inflammation: neural circuits in the regulation of immunity. Immunol Rev. 2012;248(1):188-204.
Olofsson, P. S., Rosas-Ballina, M., Levine, Y. A., & Tracey, K. J. (2012). Rethinking inflammation: neural circuits in the regulation of immunity. Immunological Reviews, 248(1), 188-204. https://doi.org/10.1111/j.1600-065X.2012.01138.x
Olofsson PS, et al. Rethinking Inflammation: Neural Circuits in the Regulation of Immunity. Immunol Rev. 2012;248(1):188-204. PubMed PMID: 22725962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rethinking inflammation: neural circuits in the regulation of immunity. AU - Olofsson,Peder S, AU - Rosas-Ballina,Mauricio, AU - Levine,Yaakov A, AU - Tracey,Kevin J, PY - 2012/6/26/entrez PY - 2012/6/26/pubmed PY - 2012/10/25/medline SP - 188 EP - 204 JF - Immunological reviews JO - Immunol Rev VL - 248 IS - 1 N2 - Neural reflex circuits regulate cytokine release to prevent potentially damaging inflammation and maintain homeostasis. In the inflammatory reflex, sensory input elicited by infection or injury travels through the afferent vagus nerve to integrative regions in the brainstem, and efferent nerves carry outbound signals that terminate in the spleen and other tissues. Neurotransmitters from peripheral autonomic nerves subsequently promote acetylcholine-release from a subset of CD4(+) T cells that relay the neural signal to other immune cells, e.g. through activation of α7 nicotinic acetylcholine receptors on macrophages. Here, we review recent progress in the understanding of the inflammatory reflex and discuss potential therapeutic implications of current findings in this evolving field. SN - 1600-065X UR - https://www.unboundmedicine.com/medline/citation/22725962/Rethinking_inflammation:_neural_circuits_in_the_regulation_of_immunity_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-2896&date=2012&volume=248&spage=188 DB - PRIME DP - Unbound Medicine ER -