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Glycemic load, glycemic index and risk of cardiovascular diseases: meta-analyses of prospective studies.
Atherosclerosis. 2012 Aug; 223(2):491-6.A

Abstract

OBJECTIVE

The objective of this study was to assess the relations between glycemic load (GL), glycemic index (GI) and the risk of fatal or nonfatal cardiovascular diseases (CVDs).

METHODS

Prospective studies were identified by a comprehensive search of Pubmed, ISI web of Science, the Cochrane Library and EMBASE database, supplemented with manual searches through the reference lists of original publications and review articles. Relative risks (RRs) and 95% confidence intervals (CIs) were extracted and pooled using a random-effect model, and dose-response meta-analysis was performed by the method of generalized least-squares.

RESULTS

Fourteen studies were identified, involving 229,213 participants and more than 11,363 cases. The pooled RRs of CVDs risk for the highest vs lowest categories of GL and GI were 1.23 (95% CI: 1.11-1.36) and 1.13 (95% CI: 1.04-1.22) respectively. Both the risk estimates of GL and GI for women (GL: RR = 1.35, 95% CI: 1.18-1.55; GI: RR = 1.19, 95% CI: 1.06-1.34) were higher than men (GL: RR = 1.10, 95% CI: 0.95-1.28; GI: RR = 1.05, 95% CI: 0.94-1.17). No heterogeneity or publication bias was detected. Dose-response meta-analysis found an increased RR of 1.18 (95% CI: 1.01-1.38, P = 0.033) per 50 unit increment of GL with cardiac event risk in Caucasians.

CONCLUSIONS

High GL and GI were associated with significant increased risk of CVDs, specifically for women.

Authors+Show Affiliations

Department of Cardiology, Southwest Hospital, Third Military Medical University, Gaotanyan Street 30, Chongqing 400038, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22727193

Citation

Ma, Xiang-Yu, et al. "Glycemic Load, Glycemic Index and Risk of Cardiovascular Diseases: Meta-analyses of Prospective Studies." Atherosclerosis, vol. 223, no. 2, 2012, pp. 491-6.
Ma XY, Liu JP, Song ZY. Glycemic load, glycemic index and risk of cardiovascular diseases: meta-analyses of prospective studies. Atherosclerosis. 2012;223(2):491-6.
Ma, X. Y., Liu, J. P., & Song, Z. Y. (2012). Glycemic load, glycemic index and risk of cardiovascular diseases: meta-analyses of prospective studies. Atherosclerosis, 223(2), 491-6. https://doi.org/10.1016/j.atherosclerosis.2012.05.028
Ma XY, Liu JP, Song ZY. Glycemic Load, Glycemic Index and Risk of Cardiovascular Diseases: Meta-analyses of Prospective Studies. Atherosclerosis. 2012;223(2):491-6. PubMed PMID: 22727193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycemic load, glycemic index and risk of cardiovascular diseases: meta-analyses of prospective studies. AU - Ma,Xiang-Yu, AU - Liu,Jian-Ping, AU - Song,Zhi-Yuan, Y1 - 2012/06/06/ PY - 2012/04/09/received PY - 2012/05/23/revised PY - 2012/05/23/accepted PY - 2012/6/26/entrez PY - 2012/6/26/pubmed PY - 2013/1/4/medline SP - 491 EP - 6 JF - Atherosclerosis JO - Atherosclerosis VL - 223 IS - 2 N2 - OBJECTIVE: The objective of this study was to assess the relations between glycemic load (GL), glycemic index (GI) and the risk of fatal or nonfatal cardiovascular diseases (CVDs). METHODS: Prospective studies were identified by a comprehensive search of Pubmed, ISI web of Science, the Cochrane Library and EMBASE database, supplemented with manual searches through the reference lists of original publications and review articles. Relative risks (RRs) and 95% confidence intervals (CIs) were extracted and pooled using a random-effect model, and dose-response meta-analysis was performed by the method of generalized least-squares. RESULTS: Fourteen studies were identified, involving 229,213 participants and more than 11,363 cases. The pooled RRs of CVDs risk for the highest vs lowest categories of GL and GI were 1.23 (95% CI: 1.11-1.36) and 1.13 (95% CI: 1.04-1.22) respectively. Both the risk estimates of GL and GI for women (GL: RR = 1.35, 95% CI: 1.18-1.55; GI: RR = 1.19, 95% CI: 1.06-1.34) were higher than men (GL: RR = 1.10, 95% CI: 0.95-1.28; GI: RR = 1.05, 95% CI: 0.94-1.17). No heterogeneity or publication bias was detected. Dose-response meta-analysis found an increased RR of 1.18 (95% CI: 1.01-1.38, P = 0.033) per 50 unit increment of GL with cardiac event risk in Caucasians. CONCLUSIONS: High GL and GI were associated with significant increased risk of CVDs, specifically for women. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/22727193/Glycemic_load_glycemic_index_and_risk_of_cardiovascular_diseases:_meta_analyses_of_prospective_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(12)00338-3 DB - PRIME DP - Unbound Medicine ER -