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Vitamin B1 in the treatment of Wernicke's encephalopathy due to hyperemesis after gastroplasty.
J Clin Neurosci. 2012 Sep; 19(9):1303-5.JC

Abstract

Wernicke's encephalopathy (WE) is a severe brain disorder, first described in 1881, and is caused by a nutritional deficiency of thiamine (vitamin B1) found mostly in patients suffering from chronic alcoholism. In addition, WE can also complicate bariatric surgery if adequate vitamin supplementation is not insured. Without immediate treatment, the prognosis is poor and the mortality rate is high. Most patients present with atypical neurological symptoms, which hampers rapid diagnosis. We present a 40-year-old woman who underwent gastroplasty combined with gastric banding for severe obesity. She experienced repetitive vomiting and her diet was without vitamin supplementation. After three months she developed convergent strabismus, apathy and urinary incontinence, which was diagnosed as WE and treated as such. Six months later her recovery was incomplete, still showing gait difficulties and nystagmus. We aim to show that adequate vitamin supplementation in patients undergoing gastroplasty is necessary, especially considering the risk of permanent neurological deficits.

Authors+Show Affiliations

New England Center for Stroke Research (NECStR), Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA. anna.kuhn@umassmed.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22727204

Citation

Kühn, A L., et al. "Vitamin B1 in the Treatment of Wernicke's Encephalopathy Due to Hyperemesis After Gastroplasty." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 19, no. 9, 2012, pp. 1303-5.
Kühn AL, Hertel F, Boulanger T, et al. Vitamin B1 in the treatment of Wernicke's encephalopathy due to hyperemesis after gastroplasty. J Clin Neurosci. 2012;19(9):1303-5.
Kühn, A. L., Hertel, F., Boulanger, T., & Diederich, N. J. (2012). Vitamin B1 in the treatment of Wernicke's encephalopathy due to hyperemesis after gastroplasty. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 19(9), 1303-5. https://doi.org/10.1016/j.jocn.2011.11.030
Kühn AL, et al. Vitamin B1 in the Treatment of Wernicke's Encephalopathy Due to Hyperemesis After Gastroplasty. J Clin Neurosci. 2012;19(9):1303-5. PubMed PMID: 22727204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B1 in the treatment of Wernicke's encephalopathy due to hyperemesis after gastroplasty. AU - Kühn,A L, AU - Hertel,F, AU - Boulanger,T, AU - Diederich,N J, Y1 - 2012/06/21/ PY - 2011/11/05/received PY - 2011/11/09/accepted PY - 2012/6/26/entrez PY - 2012/6/26/pubmed PY - 2012/12/28/medline SP - 1303 EP - 5 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 19 IS - 9 N2 - Wernicke's encephalopathy (WE) is a severe brain disorder, first described in 1881, and is caused by a nutritional deficiency of thiamine (vitamin B1) found mostly in patients suffering from chronic alcoholism. In addition, WE can also complicate bariatric surgery if adequate vitamin supplementation is not insured. Without immediate treatment, the prognosis is poor and the mortality rate is high. Most patients present with atypical neurological symptoms, which hampers rapid diagnosis. We present a 40-year-old woman who underwent gastroplasty combined with gastric banding for severe obesity. She experienced repetitive vomiting and her diet was without vitamin supplementation. After three months she developed convergent strabismus, apathy and urinary incontinence, which was diagnosed as WE and treated as such. Six months later her recovery was incomplete, still showing gait difficulties and nystagmus. We aim to show that adequate vitamin supplementation in patients undergoing gastroplasty is necessary, especially considering the risk of permanent neurological deficits. SN - 1532-2653 UR - https://www.unboundmedicine.com/medline/citation/22727204/Vitamin_B1_in_the_treatment_of_Wernicke's_encephalopathy_due_to_hyperemesis_after_gastroplasty_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(12)00061-6 DB - PRIME DP - Unbound Medicine ER -