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Changes in lipid content and fatty acid composition along the reproductive cycle of the freshwater mussel Dreissena polymorpha: its modulation by clofibrate exposure.
Sci Total Environ. 2012 Aug 15; 432:195-201.ST

Abstract

Total lipids and fatty acid profiles were determined along the reproductive cycle of the zebra mussel (Dreissena polymorpha). A total of 33 fatty acids with carbon atoms from 14 to 22 were identified: palmitic acid (16:0) was the most abundant fatty acid (13-24%) followed by docosahexaenoic acid (DHA; 22:6n-3), eicosapentaenoic acid (EPA; 20:5n-3) and palmitoleic acid (16:1n-7). Some individual fatty acids (16:0, 16:2n-4, 18:1n-7, 18:2n-6, 18:3n-4, 18:4n-3, 20:4n-3, 20:5n-3) were strongly related to reproductive events, while others having structural-type functions (18:0 and 22:6n-3) were rather stable during the study period. Multivariate analysis of the whole data set using the multivariate curve resolution alternating least squares method confirmed the strong relationship of fatty acid profiles with the reproductive cycle of zebra mussel. Additionally, the effects of the pharmaceutical clofibrate on lipid composition and fatty acid profiles were assessed following 7-day exposure of zebra mussels to a wide range of concentrations (20 ng/L to 2 mg/L). A significant reduction in total triglycerides (38%-48%) together with an increase in the amount of fatty acids per gram wet weight (1.5- to 2.2-fold) was observed in the exposed mussels. This work highlights the ability of clofibrate to induce changes on the lipidome of zebra mussels at concentrations as low as 200 ng/L.

Authors+Show Affiliations

Environmental Chemistry Department, IDAEA‐CSIC, C/Jordi Girona 18, 08034 Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22728965

Citation

Lazzara, Raimondo, et al. "Changes in Lipid Content and Fatty Acid Composition Along the Reproductive Cycle of the Freshwater Mussel Dreissena Polymorpha: Its Modulation By Clofibrate Exposure." The Science of the Total Environment, vol. 432, 2012, pp. 195-201.
Lazzara R, Fernandes D, Faria M, et al. Changes in lipid content and fatty acid composition along the reproductive cycle of the freshwater mussel Dreissena polymorpha: its modulation by clofibrate exposure. Sci Total Environ. 2012;432:195-201.
Lazzara, R., Fernandes, D., Faria, M., López, J. F., Tauler, R., & Porte, C. (2012). Changes in lipid content and fatty acid composition along the reproductive cycle of the freshwater mussel Dreissena polymorpha: its modulation by clofibrate exposure. The Science of the Total Environment, 432, 195-201. https://doi.org/10.1016/j.scitotenv.2012.05.094
Lazzara R, et al. Changes in Lipid Content and Fatty Acid Composition Along the Reproductive Cycle of the Freshwater Mussel Dreissena Polymorpha: Its Modulation By Clofibrate Exposure. Sci Total Environ. 2012 Aug 15;432:195-201. PubMed PMID: 22728965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in lipid content and fatty acid composition along the reproductive cycle of the freshwater mussel Dreissena polymorpha: its modulation by clofibrate exposure. AU - Lazzara,Raimondo, AU - Fernandes,Denise, AU - Faria,Melissa, AU - López,Jordi F, AU - Tauler,Romà, AU - Porte,Cinta, Y1 - 2012/06/23/ PY - 2012/03/14/received PY - 2012/05/29/revised PY - 2012/05/30/accepted PY - 2012/6/26/entrez PY - 2012/6/26/pubmed PY - 2012/12/12/medline SP - 195 EP - 201 JF - The Science of the total environment JO - Sci. Total Environ. VL - 432 N2 - Total lipids and fatty acid profiles were determined along the reproductive cycle of the zebra mussel (Dreissena polymorpha). A total of 33 fatty acids with carbon atoms from 14 to 22 were identified: palmitic acid (16:0) was the most abundant fatty acid (13-24%) followed by docosahexaenoic acid (DHA; 22:6n-3), eicosapentaenoic acid (EPA; 20:5n-3) and palmitoleic acid (16:1n-7). Some individual fatty acids (16:0, 16:2n-4, 18:1n-7, 18:2n-6, 18:3n-4, 18:4n-3, 20:4n-3, 20:5n-3) were strongly related to reproductive events, while others having structural-type functions (18:0 and 22:6n-3) were rather stable during the study period. Multivariate analysis of the whole data set using the multivariate curve resolution alternating least squares method confirmed the strong relationship of fatty acid profiles with the reproductive cycle of zebra mussel. Additionally, the effects of the pharmaceutical clofibrate on lipid composition and fatty acid profiles were assessed following 7-day exposure of zebra mussels to a wide range of concentrations (20 ng/L to 2 mg/L). A significant reduction in total triglycerides (38%-48%) together with an increase in the amount of fatty acids per gram wet weight (1.5- to 2.2-fold) was observed in the exposed mussels. This work highlights the ability of clofibrate to induce changes on the lipidome of zebra mussels at concentrations as low as 200 ng/L. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/22728965/Changes_in_lipid_content_and_fatty_acid_composition_along_the_reproductive_cycle_of_the_freshwater_mussel_Dreissena_polymorpha:_its_modulation_by_clofibrate_exposure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(12)00809-1 DB - PRIME DP - Unbound Medicine ER -