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Cellular and molecular mechanisms of antioxidants in Parkinson's disease.
Nutr Neurosci. 2012 May; 15(3):120-6.NN

Abstract

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the degeneration and progressive loss of dopaminergic neurons in the substantia nigra pars compacta. It has been suggested that oxidative stress plays a role in the etiology and progression of PD. For instance, low levels of endogenous antioxidants, increased reactive species, augmented dopamine oxidation, and high iron levels have been found in brains from PD patients. In vitro and in vivo studies of Parkinson models evaluating natural and endogenous antioxidants such as polyphenols, coenzyme Q10, and vitamins A, C, and E have shown protective effects against oxidative-induced neuronal death. In this paper, we will review the mechanisms by which polyphenols and endogenous antioxidants can produce protection. Some of the mechanisms reviewed include: scavenging nitrogen and oxygen reactive species, regulation of signaling pathways associated with cell survival and inflammation, and inhibition of synphilin-1 and alpha-synuclein aggregation.

Authors+Show Affiliations

Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22732354

Citation

Sutachan, Jhon Jairo, et al. "Cellular and Molecular Mechanisms of Antioxidants in Parkinson's Disease." Nutritional Neuroscience, vol. 15, no. 3, 2012, pp. 120-6.
Sutachan JJ, Casas Z, Albarracin SL, et al. Cellular and molecular mechanisms of antioxidants in Parkinson's disease. Nutr Neurosci. 2012;15(3):120-6.
Sutachan, J. J., Casas, Z., Albarracin, S. L., Stab, B. R., Samudio, I., Gonzalez, J., Morales, L., & Barreto, G. E. (2012). Cellular and molecular mechanisms of antioxidants in Parkinson's disease. Nutritional Neuroscience, 15(3), 120-6. https://doi.org/10.1179/1476830511Y.0000000033
Sutachan JJ, et al. Cellular and Molecular Mechanisms of Antioxidants in Parkinson's Disease. Nutr Neurosci. 2012;15(3):120-6. PubMed PMID: 22732354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cellular and molecular mechanisms of antioxidants in Parkinson's disease. AU - Sutachan,Jhon Jairo, AU - Casas,Zulma, AU - Albarracin,Sonia Luz, AU - Stab,Bernd Robert,2nd AU - Samudio,Ismael, AU - Gonzalez,Janneth, AU - Morales,Ludis, AU - Barreto,George E, PY - 2012/6/27/entrez PY - 2012/6/27/pubmed PY - 2012/11/10/medline SP - 120 EP - 6 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 15 IS - 3 N2 - Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the degeneration and progressive loss of dopaminergic neurons in the substantia nigra pars compacta. It has been suggested that oxidative stress plays a role in the etiology and progression of PD. For instance, low levels of endogenous antioxidants, increased reactive species, augmented dopamine oxidation, and high iron levels have been found in brains from PD patients. In vitro and in vivo studies of Parkinson models evaluating natural and endogenous antioxidants such as polyphenols, coenzyme Q10, and vitamins A, C, and E have shown protective effects against oxidative-induced neuronal death. In this paper, we will review the mechanisms by which polyphenols and endogenous antioxidants can produce protection. Some of the mechanisms reviewed include: scavenging nitrogen and oxygen reactive species, regulation of signaling pathways associated with cell survival and inflammation, and inhibition of synphilin-1 and alpha-synuclein aggregation. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/22732354/Cellular_and_molecular_mechanisms_of_antioxidants_in_Parkinson's_disease_ L2 - https://www.tandfonline.com/doi/full/10.1179/1476830511Y.0000000033 DB - PRIME DP - Unbound Medicine ER -