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Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.
J Ethnopharmacol. 2012 Aug 01; 142(3):845-50.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases.

AIM OF THE STUDY

The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be useful to treat gouty arthritis by countering hyperuricemia and inflammation.

MATERIALS AND METHODS

L. trichocarpha ethanolic extract (LTE), ethyl acetate fraction from ethanolic extract (LTA) and isolated compounds were evaluated for urate-lowering activity and liver xanthine oxidase (XOD) inhibition in oxonate-induced hyperuricemic mice. Anti-inflammatory activity in monosodium urate crystal-induced paw oedema, an experimental model of gouty arthritis, was also investigated.

RESULTS

Crude ethanolic extract and its ethyl acetate fraction showed significant urate-lowering effects. LTE was also able to significantly inhibit liver xantine oxidase (XOD) activity in vivo at the dose of 250mg/kg. Luteolin, apigenin, lupeol, lychnopholide and eremantholide C showed the anti-hyperuricemic activities among tested compounds. Apigenin also showed XOD inhibitory activity in vivo. Luteolin, lychnopholide, lupeol and eremantholide C, in turn, did not shown significant inhibitory activity towards this enzyme, indicating that this mechanism is not likely to be involved in urate-lowering effects of those compounds. LTE, LTA, lupeol, β-sitosterol, lychnopholide, eremantholide, luteolin and apigenin were also found to inhibit monosodium urate crystals-induced paw oedema in mice.

CONCLUSIONS

Ethanolic extract of Lychnophora trichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possesses both anti-hiperuricemic and anti-inflammatory properties.

Authors+Show Affiliations

Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22732730

Citation

de Souza, Maíra Ribeiro, et al. "Pharmacological Basis for Use of Lychnophora Trichocarpha in Gouty Arthritis: Anti-hyperuricemic and Anti-inflammatory Effects of Its Extract, Fraction and Constituents." Journal of Ethnopharmacology, vol. 142, no. 3, 2012, pp. 845-50.
de Souza MR, de Paula CA, Pereira de Resende ML, et al. Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents. J Ethnopharmacol. 2012;142(3):845-50.
de Souza, M. R., de Paula, C. A., Pereira de Resende, M. L., Grabe-Guimarães, A., de Souza Filho, J. D., & Saúde-Guimarães, D. A. (2012). Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents. Journal of Ethnopharmacology, 142(3), 845-50. https://doi.org/10.1016/j.jep.2012.06.012
de Souza MR, et al. Pharmacological Basis for Use of Lychnophora Trichocarpha in Gouty Arthritis: Anti-hyperuricemic and Anti-inflammatory Effects of Its Extract, Fraction and Constituents. J Ethnopharmacol. 2012 Aug 1;142(3):845-50. PubMed PMID: 22732730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents. AU - de Souza,Maíra Ribeiro, AU - de Paula,Carmen Aparecida, AU - Pereira de Resende,Michelle Luciane, AU - Grabe-Guimarães,Andrea, AU - de Souza Filho,José Dias, AU - Saúde-Guimarães,Dênia Antunes, Y1 - 2012/06/23/ PY - 2012/03/18/received PY - 2012/05/29/revised PY - 2012/06/06/accepted PY - 2012/6/27/entrez PY - 2012/6/27/pubmed PY - 2012/12/15/medline SP - 845 EP - 50 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 142 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases. AIM OF THE STUDY: The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be useful to treat gouty arthritis by countering hyperuricemia and inflammation. MATERIALS AND METHODS: L. trichocarpha ethanolic extract (LTE), ethyl acetate fraction from ethanolic extract (LTA) and isolated compounds were evaluated for urate-lowering activity and liver xanthine oxidase (XOD) inhibition in oxonate-induced hyperuricemic mice. Anti-inflammatory activity in monosodium urate crystal-induced paw oedema, an experimental model of gouty arthritis, was also investigated. RESULTS: Crude ethanolic extract and its ethyl acetate fraction showed significant urate-lowering effects. LTE was also able to significantly inhibit liver xantine oxidase (XOD) activity in vivo at the dose of 250mg/kg. Luteolin, apigenin, lupeol, lychnopholide and eremantholide C showed the anti-hyperuricemic activities among tested compounds. Apigenin also showed XOD inhibitory activity in vivo. Luteolin, lychnopholide, lupeol and eremantholide C, in turn, did not shown significant inhibitory activity towards this enzyme, indicating that this mechanism is not likely to be involved in urate-lowering effects of those compounds. LTE, LTA, lupeol, β-sitosterol, lychnopholide, eremantholide, luteolin and apigenin were also found to inhibit monosodium urate crystals-induced paw oedema in mice. CONCLUSIONS: Ethanolic extract of Lychnophora trichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possesses both anti-hiperuricemic and anti-inflammatory properties. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22732730/Pharmacological_basis_for_use_of_Lychnophora_trichocarpha_in_gouty_arthritis:_anti_hyperuricemic_and_anti_inflammatory_effects_of_its_extract_fraction_and_constituents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00399-6 DB - PRIME DP - Unbound Medicine ER -