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Fat or fit: the joint effects of physical activity, weight gain, and body size on breast cancer risk.
Cancer 2012; 118(19):4860-8C

Abstract

BACKGROUND

Although physical activity reduces breast cancer risk, issues critical to providing clear public health messages remain to be elucidated. These include the minimum duration and intensity necessary for risk reduction and the optimal time period for occurrence, as well as subgroup effects, particularly with regard to tumor heterogeneity and body size.

METHODS

This study investigated the relationship between recreational physical activity (RPA) and breast cancer risk, in addition to characterizing the joint effects of activity level, weight gain, and body size, through use of a population-based sample of 1504 cases (N = 233 in situ, N = 1271 invasive) and 1555 controls (aged 20-98 years) from the Long Island Breast Cancer Study Project, in Long Island, New York.

RESULTS

A nonlinear dose-response association was observed between breast cancer risk and RPA during the reproductive period and after menopause. Women in the third quartile of activity experienced the greatest benefit with an approximate 30% risk reduction for reproductive (odds ratio = 0.67; 95% confidence interval = 0.48-0.94) and postmenopausal activity (odds ratio = 0.70; 95% confidence interval = 0.52-0.95). Little to no difference was observed regarding intensity of activity or hormone receptor status. Joint assessment of RPA, weight gain, and body size revealed that women with unfavorable energy balance profiles were at increased breast cancer risk. A significant multiplicative interaction was observed between RPA and adult weight gain (P = .033).

CONCLUSIONS

RPA at any intensity level during the reproductive and postmenopausal years have the greatest benefit for reducing breast cancer risk. Substantial postmenopausal weight gain may eliminate the benefits of regular activity.

Authors+Show Affiliations

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA. lauren.mccullough@unc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22733561

Citation

McCullough, Lauren E., et al. "Fat or Fit: the Joint Effects of Physical Activity, Weight Gain, and Body Size On Breast Cancer Risk." Cancer, vol. 118, no. 19, 2012, pp. 4860-8.
McCullough LE, Eng SM, Bradshaw PT, et al. Fat or fit: the joint effects of physical activity, weight gain, and body size on breast cancer risk. Cancer. 2012;118(19):4860-8.
McCullough, L. E., Eng, S. M., Bradshaw, P. T., Cleveland, R. J., Teitelbaum, S. L., Neugut, A. I., & Gammon, M. D. (2012). Fat or fit: the joint effects of physical activity, weight gain, and body size on breast cancer risk. Cancer, 118(19), pp. 4860-8. doi:10.1002/cncr.27433.
McCullough LE, et al. Fat or Fit: the Joint Effects of Physical Activity, Weight Gain, and Body Size On Breast Cancer Risk. Cancer. 2012 Oct 1;118(19):4860-8. PubMed PMID: 22733561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fat or fit: the joint effects of physical activity, weight gain, and body size on breast cancer risk. AU - McCullough,Lauren E, AU - Eng,Sybil M, AU - Bradshaw,Patrick T, AU - Cleveland,Rebecca J, AU - Teitelbaum,Susan L, AU - Neugut,Alfred I, AU - Gammon,Marilie D, Y1 - 2012/06/25/ PY - 2011/08/23/received PY - 2011/11/12/revised PY - 2011/12/19/accepted PY - 2012/6/27/entrez PY - 2012/6/27/pubmed PY - 2012/12/10/medline SP - 4860 EP - 8 JF - Cancer JO - Cancer VL - 118 IS - 19 N2 - BACKGROUND: Although physical activity reduces breast cancer risk, issues critical to providing clear public health messages remain to be elucidated. These include the minimum duration and intensity necessary for risk reduction and the optimal time period for occurrence, as well as subgroup effects, particularly with regard to tumor heterogeneity and body size. METHODS: This study investigated the relationship between recreational physical activity (RPA) and breast cancer risk, in addition to characterizing the joint effects of activity level, weight gain, and body size, through use of a population-based sample of 1504 cases (N = 233 in situ, N = 1271 invasive) and 1555 controls (aged 20-98 years) from the Long Island Breast Cancer Study Project, in Long Island, New York. RESULTS: A nonlinear dose-response association was observed between breast cancer risk and RPA during the reproductive period and after menopause. Women in the third quartile of activity experienced the greatest benefit with an approximate 30% risk reduction for reproductive (odds ratio = 0.67; 95% confidence interval = 0.48-0.94) and postmenopausal activity (odds ratio = 0.70; 95% confidence interval = 0.52-0.95). Little to no difference was observed regarding intensity of activity or hormone receptor status. Joint assessment of RPA, weight gain, and body size revealed that women with unfavorable energy balance profiles were at increased breast cancer risk. A significant multiplicative interaction was observed between RPA and adult weight gain (P = .033). CONCLUSIONS: RPA at any intensity level during the reproductive and postmenopausal years have the greatest benefit for reducing breast cancer risk. Substantial postmenopausal weight gain may eliminate the benefits of regular activity. SN - 1097-0142 UR - https://www.unboundmedicine.com/medline/citation/22733561/Fat_or_fit:_the_joint_effects_of_physical_activity_weight_gain_and_body_size_on_breast_cancer_risk_ L2 - https://doi.org/10.1002/cncr.27433 DB - PRIME DP - Unbound Medicine ER -