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Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug.
Indian J Exp Biol. 2012 Jun; 50(6):413-8.IJ

Abstract

There is general belief that only pure phytomolecules may be used as molecular therapeutic agent through one to one action. However, the traditional systems of medicine e.g. Ayurveda, uses the crude extracts, mostly water decoctions and oils, as drug. A comparative study of hexane, ethyl acetate and methanol fractions of N. Sativa seeds has been carried out on fresh rat-peritoneal-macrophage culture with reference to their role on various targets of lipopolysaccharide induced release of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression. The results indicated significant antioxidant potential with methanolic extract as most effective. Its mechanism of action was proposed primarily through its antioxidant potential and not through direct inhibition of other kinases, involved in its signaling cascade.

Authors+Show Affiliations

Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India. yaminiok@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22734252

Citation

Tripathi, Yamini B., et al. "Effect of Nigella Sativa Seeds Extracts On iNOS Through Antioxidant Potential Only: Crude/total Extract as Molecular Therapy Drug." Indian Journal of Experimental Biology, vol. 50, no. 6, 2012, pp. 413-8.
Tripathi YB, Chaturvedi AP, Pandey N. Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug. Indian J Exp Biol. 2012;50(6):413-8.
Tripathi, Y. B., Chaturvedi, A. P., & Pandey, N. (2012). Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug. Indian Journal of Experimental Biology, 50(6), 413-8.
Tripathi YB, Chaturvedi AP, Pandey N. Effect of Nigella Sativa Seeds Extracts On iNOS Through Antioxidant Potential Only: Crude/total Extract as Molecular Therapy Drug. Indian J Exp Biol. 2012;50(6):413-8. PubMed PMID: 22734252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug. AU - Tripathi,Yamini B, AU - Chaturvedi,A P, AU - Pandey,Nidhi, PY - 2012/6/28/entrez PY - 2012/6/28/pubmed PY - 2012/8/24/medline SP - 413 EP - 8 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 50 IS - 6 N2 - There is general belief that only pure phytomolecules may be used as molecular therapeutic agent through one to one action. However, the traditional systems of medicine e.g. Ayurveda, uses the crude extracts, mostly water decoctions and oils, as drug. A comparative study of hexane, ethyl acetate and methanol fractions of N. Sativa seeds has been carried out on fresh rat-peritoneal-macrophage culture with reference to their role on various targets of lipopolysaccharide induced release of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression. The results indicated significant antioxidant potential with methanolic extract as most effective. Its mechanism of action was proposed primarily through its antioxidant potential and not through direct inhibition of other kinases, involved in its signaling cascade. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/22734252/Effect_of_Nigella_sativa_seeds_extracts_on_iNOS_through_antioxidant_potential_only:_crude/total_extract_as_molecular_therapy_drug_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -