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Vitamin D and multiple sclerosis.
Neurologist 2012; 18(4):179-83N

Abstract

BACKGROUND

Epidemiological data support a potential relationship between vitamin D deficiency and an increased risk of developing multiple sclerosis (MS). In vitro studies have expanded the potential role of vitamin D and its receptor beyond calcium modulation, regulation, and maintenance of bone mineralization, to include immune modulation.

REVIEW SUMMARY

Whether vitamin D immunomodulatory effects can be translated into clinical benefits in MS patients is still a matter of debate. A review of the biochemistry of vitamin D and its synthesized derivatives is discussed in the context of treating vitamin D deficiency. Animal studies, which led to some human studies, are also discussed. Future studies are pending and will likely yield conclusive results as to the benefit and possible synergistic effects of vitamin D with other disease-modifying therapies of MS.

CONCLUSIONS

Further prospective studies are needed to identify vitamin D levels during the various phases of MS, including relapses, remissions and progression, and to determine whether correcting vitamin D during any or all of these phases may affect the incidence or even the course of the disease.

Authors+Show Affiliations

Jacobs Neurological Institute, Buffalo, NY 14203, USA. bweinstock-guttman@kaleidahealth.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

22735240

Citation

Weinstock-Guttman, Bianca, et al. "Vitamin D and Multiple Sclerosis." The Neurologist, vol. 18, no. 4, 2012, pp. 179-83.
Weinstock-Guttman B, Mehta BK, Ramanathan M, et al. Vitamin D and multiple sclerosis. Neurologist. 2012;18(4):179-83.
Weinstock-Guttman, B., Mehta, B. K., Ramanathan, M., Karmon, Y., Henson, L. J., Halper, J., & Riskind, P. (2012). Vitamin D and multiple sclerosis. The Neurologist, 18(4), pp. 179-83. doi:10.1097/NRL.0b013e31825bbf35.
Weinstock-Guttman B, et al. Vitamin D and Multiple Sclerosis. Neurologist. 2012;18(4):179-83. PubMed PMID: 22735240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and multiple sclerosis. AU - Weinstock-Guttman,Bianca, AU - Mehta,Bijal K, AU - Ramanathan,Murali, AU - Karmon,Yuval, AU - Henson,Lily Jung, AU - Halper,June, AU - Riskind,Peter, PY - 2012/6/28/entrez PY - 2012/6/28/pubmed PY - 2012/10/30/medline SP - 179 EP - 83 JF - The neurologist JO - Neurologist VL - 18 IS - 4 N2 - BACKGROUND: Epidemiological data support a potential relationship between vitamin D deficiency and an increased risk of developing multiple sclerosis (MS). In vitro studies have expanded the potential role of vitamin D and its receptor beyond calcium modulation, regulation, and maintenance of bone mineralization, to include immune modulation. REVIEW SUMMARY: Whether vitamin D immunomodulatory effects can be translated into clinical benefits in MS patients is still a matter of debate. A review of the biochemistry of vitamin D and its synthesized derivatives is discussed in the context of treating vitamin D deficiency. Animal studies, which led to some human studies, are also discussed. Future studies are pending and will likely yield conclusive results as to the benefit and possible synergistic effects of vitamin D with other disease-modifying therapies of MS. CONCLUSIONS: Further prospective studies are needed to identify vitamin D levels during the various phases of MS, including relapses, remissions and progression, and to determine whether correcting vitamin D during any or all of these phases may affect the incidence or even the course of the disease. SN - 2331-2637 UR - https://www.unboundmedicine.com/medline/citation/22735240/Vitamin_D_and_multiple_sclerosis_ L2 - http://Insights.ovid.com/pubmed?pmid=22735240 DB - PRIME DP - Unbound Medicine ER -