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Genotoxicity of Euphorbia hirta: an Allium cepa assay.
Molecules. 2012 Jun 26; 17(7):7782-91.M

Abstract

The potential genotoxic effects of methanolic extracts of Euphorbia hirta which is commonly used in traditional medicine to treat a variety of diseased conditions including asthma, coughs, diarrhea and dysentery was investigated using Allium cepa assay. The extracts of 125, 250, 500 and 1,000 µg/mL were tested on root meristems of A. cepa. Ethylmethanesulfonate was used as positive control and distilled water was used as negative control. The result showed that mitotic index decreased as the concentrations of E. hirta extract increased. A dose-dependent increase of chromosome aberrations was also observed. Abnormalities scored were stickiness, c-mitosis, bridges and vagrant chromosomes. Micronucleated cells were also observed at interphase. Result of this study confirmed that the methanol extracts of E. hirta exerted significant genotoxic and mitodepressive effects at 1,000 µg/mL.

Authors+Show Affiliations

Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Pulau Pinang, Malaysia. joyc_ping@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22735780

Citation

Yuet Ping, Kwan, et al. "Genotoxicity of Euphorbia Hirta: an Allium Cepa Assay." Molecules (Basel, Switzerland), vol. 17, no. 7, 2012, pp. 7782-91.
Yuet Ping K, Darah I, Yusuf UK, et al. Genotoxicity of Euphorbia hirta: an Allium cepa assay. Molecules. 2012;17(7):7782-91.
Yuet Ping, K., Darah, I., Yusuf, U. K., Yeng, C., & Sasidharan, S. (2012). Genotoxicity of Euphorbia hirta: an Allium cepa assay. Molecules (Basel, Switzerland), 17(7), 7782-91. https://doi.org/10.3390/molecules17077782
Yuet Ping K, et al. Genotoxicity of Euphorbia Hirta: an Allium Cepa Assay. Molecules. 2012 Jun 26;17(7):7782-91. PubMed PMID: 22735780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genotoxicity of Euphorbia hirta: an Allium cepa assay. AU - Yuet Ping,Kwan, AU - Darah,Ibrahim, AU - Yusuf,Umi Kalsom, AU - Yeng,Chen, AU - Sasidharan,Sreenivasan, Y1 - 2012/06/26/ PY - 2012/04/23/received PY - 2012/06/20/revised PY - 2012/06/21/accepted PY - 2012/6/28/entrez PY - 2012/6/28/pubmed PY - 2012/10/23/medline SP - 7782 EP - 91 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 17 IS - 7 N2 - The potential genotoxic effects of methanolic extracts of Euphorbia hirta which is commonly used in traditional medicine to treat a variety of diseased conditions including asthma, coughs, diarrhea and dysentery was investigated using Allium cepa assay. The extracts of 125, 250, 500 and 1,000 µg/mL were tested on root meristems of A. cepa. Ethylmethanesulfonate was used as positive control and distilled water was used as negative control. The result showed that mitotic index decreased as the concentrations of E. hirta extract increased. A dose-dependent increase of chromosome aberrations was also observed. Abnormalities scored were stickiness, c-mitosis, bridges and vagrant chromosomes. Micronucleated cells were also observed at interphase. Result of this study confirmed that the methanol extracts of E. hirta exerted significant genotoxic and mitodepressive effects at 1,000 µg/mL. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/22735780/Genotoxicity_of_Euphorbia_hirta:_an_Allium_cepa_assay_ L2 - https://www.mdpi.com/resolver?pii=molecules17077782 DB - PRIME DP - Unbound Medicine ER -