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Role of NQO1 609C>T and NQO2 -3423G>A gene polymorphisms in esophageal cancer risk in Kashmir valley and meta analysis.
Mol Biol Rep. 2012 Sep; 39(9):9095-104.MB

Abstract

Esophageal cancer (EC) is a complex multifactorial disorder, where environmental and genetic factors play major role. NADPH:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are phase II cytosolic enzymes that catalyze metabolism of quinones, important in the detoxification of environmental carcinogens. A case-control study was performed to investigated the associations of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility to EC in a high-risk Kashmiri population of India in 135 EC patients and 195 unrelated healthy controls using PCR-RFLP. We also performed a meta analysis of nine published studies (1,224 cases and 1,740 controls) on NQO1 609C>T and evaluated the association between the NQO1 609C>T polymorphisms and esophageal cancer risk. A significant difference in NQO1 609C>T and NQO2 -3423G>A genotype distribution between EC cases and corresponding controls groups was observed (OR = 2.65; 95 % CI = 1.29-5.42 and OR = 1.88; 95 % CI = 1.02-3.49 respectively). Further, gene-gene interaction showed significantly increased risk for esophageal adenocarcinoma with variant genotypes of NQO1 609C>T and NQO2 -3423G>A polymorphisms and interaction with environmental risk factors revealed pronounced risk of EC with NQO1 609C>T TT genotype in high salted tea users of Kashmir valley (OR = 3.72, 95 % CI = 0.98-14.19). Meta analysis of NQO 609C>T polymorphism also suggested association of the polymorphism with EC in Asians as well as Europeans. In conclusion, NQO1 609C>T and NQO2 -3423G>A genetic variations modulate risk of EC in high-risk Kashmir population.

Authors+Show Affiliations

Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22736108

Citation

Malik, Manzoor Ahmad, et al. "Role of NQO1 609C>T and NQO2 -3423G>A Gene Polymorphisms in Esophageal Cancer Risk in Kashmir Valley and Meta Analysis." Molecular Biology Reports, vol. 39, no. 9, 2012, pp. 9095-104.
Malik MA, Zargar SA, Mittal B. Role of NQO1 609C>T and NQO2 -3423G>A gene polymorphisms in esophageal cancer risk in Kashmir valley and meta analysis. Mol Biol Rep. 2012;39(9):9095-104.
Malik, M. A., Zargar, S. A., & Mittal, B. (2012). Role of NQO1 609C>T and NQO2 -3423G>A gene polymorphisms in esophageal cancer risk in Kashmir valley and meta analysis. Molecular Biology Reports, 39(9), 9095-104. https://doi.org/10.1007/s11033-012-1781-y
Malik MA, Zargar SA, Mittal B. Role of NQO1 609C>T and NQO2 -3423G>A Gene Polymorphisms in Esophageal Cancer Risk in Kashmir Valley and Meta Analysis. Mol Biol Rep. 2012;39(9):9095-104. PubMed PMID: 22736108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of NQO1 609C>T and NQO2 -3423G>A gene polymorphisms in esophageal cancer risk in Kashmir valley and meta analysis. AU - Malik,Manzoor Ahmad, AU - Zargar,Showkat Ali, AU - Mittal,Balraj, Y1 - 2012/06/27/ PY - 2011/11/23/received PY - 2012/06/09/accepted PY - 2012/6/28/entrez PY - 2012/6/28/pubmed PY - 2012/12/15/medline SP - 9095 EP - 104 JF - Molecular biology reports JO - Mol Biol Rep VL - 39 IS - 9 N2 - Esophageal cancer (EC) is a complex multifactorial disorder, where environmental and genetic factors play major role. NADPH:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are phase II cytosolic enzymes that catalyze metabolism of quinones, important in the detoxification of environmental carcinogens. A case-control study was performed to investigated the associations of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility to EC in a high-risk Kashmiri population of India in 135 EC patients and 195 unrelated healthy controls using PCR-RFLP. We also performed a meta analysis of nine published studies (1,224 cases and 1,740 controls) on NQO1 609C>T and evaluated the association between the NQO1 609C>T polymorphisms and esophageal cancer risk. A significant difference in NQO1 609C>T and NQO2 -3423G>A genotype distribution between EC cases and corresponding controls groups was observed (OR = 2.65; 95 % CI = 1.29-5.42 and OR = 1.88; 95 % CI = 1.02-3.49 respectively). Further, gene-gene interaction showed significantly increased risk for esophageal adenocarcinoma with variant genotypes of NQO1 609C>T and NQO2 -3423G>A polymorphisms and interaction with environmental risk factors revealed pronounced risk of EC with NQO1 609C>T TT genotype in high salted tea users of Kashmir valley (OR = 3.72, 95 % CI = 0.98-14.19). Meta analysis of NQO 609C>T polymorphism also suggested association of the polymorphism with EC in Asians as well as Europeans. In conclusion, NQO1 609C>T and NQO2 -3423G>A genetic variations modulate risk of EC in high-risk Kashmir population. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/22736108/Role_of_NQO1_609C>T_and_NQO2__3423G>A_gene_polymorphisms_in_esophageal_cancer_risk_in_Kashmir_valley_and_meta_analysis_ L2 - https://doi.org/10.1007/s11033-012-1781-y DB - PRIME DP - Unbound Medicine ER -