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Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.

Abstract

PPARγ activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeutic agents may have opposing effects on cancer in different cells.

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  • Authors+Show Affiliations

    Department of Medicine; University of Colorado Denver; Aurora, CO USA.

    Source

    Oncoimmunology 1:3 2012 May 01 pg 403-404

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22737631