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Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes.
Biosci Biotechnol Biochem. 2012; 76(5):961-6.BB

Abstract

Angelica keiskei (Ashitaba in Japanese), a traditional herb in Japan, contains abundant prenylated chalcones. It has been reported that the chalcones from A. keiskei showed such bioactivities as anti-bacterial, anti-cancer and anti-diabetic effects. Xanthoangelol, 4-hydroxyderricin and six new chalcones were isolated in this study from an ethanol extract of A. keiskei by octadecyl silyl (ODS) and silica gel chromatography, and identified by 1D- and 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometric analyses. The chalcones from A. keiskei markedly increased the expression of the adiponectin gene and the production of adiponectin in 3T3-L1 adipocytes. These results suggest that the chalcones from A. keiskei might be useful for preventing the metabolic syndrome.

Links

Publisher Full Text
joi.jlc.jst.go.jp
tandfonline.com

Authors+Show Affiliations

Ohnogi H
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan. onogih@takara-bi.co.jp
Kudo Y
No affiliation info available
Tahara K
No affiliation info available
Sugiyama K
No affiliation info available
Enoki T
No affiliation info available
Hayami S
No affiliation info available
Sagawa H
No affiliation info available
Tanimura Y
No affiliation info available
Aoi W
No affiliation info available
Naito Y
No affiliation info available
Kato I
No affiliation info available
Yoshikawa T
No affiliation info available

MeSH

AdipocytesAdiponectinAngelicaAnimalsCell LineChalconeChromatographyEthanolGene ExpressionHypoglycemic AgentsMagnetic Resonance SpectroscopyMass SpectrometryMicePlant Roots

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22738967

Citation

Ohnogi, Hiromu, et al. "Six New Chalcones From Angelica Keiskei Inducing Adiponectin Production in 3T3-L1 Adipocytes." Bioscience, Biotechnology, and Biochemistry, vol. 76, no. 5, 2012, pp. 961-6.
Ohnogi H, Kudo Y, Tahara K, et al. Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes. Biosci Biotechnol Biochem. 2012;76(5):961-6.
Ohnogi, H., Kudo, Y., Tahara, K., Sugiyama, K., Enoki, T., Hayami, S., Sagawa, H., Tanimura, Y., Aoi, W., Naito, Y., Kato, I., & Yoshikawa, T. (2012). Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes. Bioscience, Biotechnology, and Biochemistry, 76(5), 961-6.
Ohnogi H, et al. Six New Chalcones From Angelica Keiskei Inducing Adiponectin Production in 3T3-L1 Adipocytes. Biosci Biotechnol Biochem. 2012;76(5):961-6. PubMed PMID: 22738967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes. AU - Ohnogi,Hiromu, AU - Kudo,Yoko, AU - Tahara,Kenichi, AU - Sugiyama,Katsumi, AU - Enoki,Tatsuji, AU - Hayami,Shoko, AU - Sagawa,Hiroaki, AU - Tanimura,Yuko, AU - Aoi,Wataru, AU - Naito,Yuji, AU - Kato,Ikunoshin, AU - Yoshikawa,Toshikazu, Y1 - 2012/05/07/ PY - 2012/6/29/entrez PY - 2012/6/29/pubmed PY - 2012/10/27/medline SP - 961 EP - 6 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 76 IS - 5 N2 - Angelica keiskei (Ashitaba in Japanese), a traditional herb in Japan, contains abundant prenylated chalcones. It has been reported that the chalcones from A. keiskei showed such bioactivities as anti-bacterial, anti-cancer and anti-diabetic effects. Xanthoangelol, 4-hydroxyderricin and six new chalcones were isolated in this study from an ethanol extract of A. keiskei by octadecyl silyl (ODS) and silica gel chromatography, and identified by 1D- and 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometric analyses. The chalcones from A. keiskei markedly increased the expression of the adiponectin gene and the production of adiponectin in 3T3-L1 adipocytes. These results suggest that the chalcones from A. keiskei might be useful for preventing the metabolic syndrome. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/22738967/Six_new_chalcones_from_Angelica_keiskei_inducing_adiponectin_production_in_3T3_L1_adipocytes_ L2 - https://joi.jlc.jst.go.jp/DN/JST.JSTAGE/bbb/110976?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -