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Heart healthy diet and risk of myocardial infarction and venous thromboembolism. The Tromsø Study.

Abstract

Prudent dietary patterns are associated with reduced risk of arterial cardiovascular diseases (CVD). Limited data exist on the relation between diet and venous thromboembolism (VTE). The aim of our prospective, population based study was to investigate the association of a heart healthy diet on risk of myocardial infarction (MI) and VTE. Information on dietary habits was available in 18,062 subjects, aged 25-69, who participated in the fourth Tromsø study, 1994-1995. Dietary patterns were assessed by a slightly modified version of the validated SmartDiet score; a 13-item questionnaire producing a diet score based on the intakes of fat, fibre, fruit and vegetables. Incident events of MI (n=518) and VTE (n=172) were recorded to the end of follow-up December 31, 2005 (median follow-up 10.8 years). Cox-regression models were used to calculate hazard ratios (HR). A healthy diet score of >27 points (upper tertile) was associated with 17% reduced risk of MI (HR: 0.83, 95% confidence interval [CI]: 0.66-1.06), and no association with VTE (HR: 1.01; 95%CI: 0.66-1.56), compared to <24 points (lower tertile) in multivariable analysis. High intake of fish, fruit, vegetables and polyunsatured fat had a 23% reduced risk of MI (HR 0.77; 95%CI: 0.60-0.98), but no association with VTE (HR 0.95; 95%CI: 0.64-1.40). A heart healthy diet showed an even more favourable association with MI in obese subjects (HR: 0.62; 95%CI: 0.41-0.95), but not with VTE. Our findings suggest that a heart healthy dietary pattern is associated with moderately reduced risk of MI, but not related to risk of VTE.

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  • Authors+Show Affiliations

    ,

    Hematological Research Group, Department of Clinical Sciences, University of Tromsø, Tromsø, Norway. ida.j.hansen-krone@uit.no

    , , ,

    Source

    Thrombosis and haemostasis 108:3 2012 Sep pg 554-60

    MeSH

    Adult
    Aged
    Animals
    Body Mass Index
    Diet
    Diet Surveys
    Dietary Fats
    Dietary Fiber
    Female
    Fishes
    Follow-Up Studies
    Fruit
    Habits
    Humans
    Male
    Meat
    Middle Aged
    Milk
    Myocardial Infarction
    Norway
    Proportional Hazards Models
    Prospective Studies
    Risk
    Risk Reduction Behavior
    Surveys and Questionnaires
    Urban Population
    Vegetables
    Venous Thromboembolism

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22739999

    Citation

    Hansen-Krone, Ida J., et al. "Heart Healthy Diet and Risk of Myocardial Infarction and Venous Thromboembolism. the Tromsø Study." Thrombosis and Haemostasis, vol. 108, no. 3, 2012, pp. 554-60.
    Hansen-Krone IJ, Enga KF, Njølstad I, et al. Heart healthy diet and risk of myocardial infarction and venous thromboembolism. The Tromsø Study. Thromb Haemost. 2012;108(3):554-60.
    Hansen-Krone, I. J., Enga, K. F., Njølstad, I., Hansen, J. B., & Braekkan, S. K. (2012). Heart healthy diet and risk of myocardial infarction and venous thromboembolism. The Tromsø Study. Thrombosis and Haemostasis, 108(3), pp. 554-60. doi:10.1160/TH11-11-0818.
    Hansen-Krone IJ, et al. Heart Healthy Diet and Risk of Myocardial Infarction and Venous Thromboembolism. the Tromsø Study. Thromb Haemost. 2012;108(3):554-60. PubMed PMID: 22739999.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Heart healthy diet and risk of myocardial infarction and venous thromboembolism. The Tromsø Study. AU - Hansen-Krone,Ida J, AU - Enga,Kristin F, AU - Njølstad,Inger, AU - Hansen,John-Bjarne, AU - Braekkan,Sigrid K, Y1 - 2012/06/28/ PY - 2011/11/29/received PY - 2012/05/19/accepted PY - 2012/6/29/entrez PY - 2012/6/29/pubmed PY - 2013/2/15/medline SP - 554 EP - 60 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 108 IS - 3 N2 - Prudent dietary patterns are associated with reduced risk of arterial cardiovascular diseases (CVD). Limited data exist on the relation between diet and venous thromboembolism (VTE). The aim of our prospective, population based study was to investigate the association of a heart healthy diet on risk of myocardial infarction (MI) and VTE. Information on dietary habits was available in 18,062 subjects, aged 25-69, who participated in the fourth Tromsø study, 1994-1995. Dietary patterns were assessed by a slightly modified version of the validated SmartDiet score; a 13-item questionnaire producing a diet score based on the intakes of fat, fibre, fruit and vegetables. Incident events of MI (n=518) and VTE (n=172) were recorded to the end of follow-up December 31, 2005 (median follow-up 10.8 years). Cox-regression models were used to calculate hazard ratios (HR). A healthy diet score of >27 points (upper tertile) was associated with 17% reduced risk of MI (HR: 0.83, 95% confidence interval [CI]: 0.66-1.06), and no association with VTE (HR: 1.01; 95%CI: 0.66-1.56), compared to <24 points (lower tertile) in multivariable analysis. High intake of fish, fruit, vegetables and polyunsatured fat had a 23% reduced risk of MI (HR 0.77; 95%CI: 0.60-0.98), but no association with VTE (HR 0.95; 95%CI: 0.64-1.40). A heart healthy diet showed an even more favourable association with MI in obese subjects (HR: 0.62; 95%CI: 0.41-0.95), but not with VTE. Our findings suggest that a heart healthy dietary pattern is associated with moderately reduced risk of MI, but not related to risk of VTE. SN - 2567-689X UR - https://www.unboundmedicine.com/medline/citation/22739999/Heart_healthy_diet_and_risk_of_myocardial_infarction_and_venous_thromboembolism__The_Tromsø_Study_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH11-11-0818 DB - PRIME DP - Unbound Medicine ER -