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Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes.

Abstract

Inconsistent results for the role of dairy food intake in relation to ovarian cancer risk may reflect the potential adverse effects of lactose, which has been hypothesized to increase gonadotropin levels, and the beneficial antiproliferative effects of calcium and vitamin D. Using data from the New England case-control study (1,909 cases and 1,989 controls), we examined dairy foods and nutrients in relation to risk of ovarian cancer overall, histological subtypes and rapidly fatal versus less aggressive disease. We used logistic regression and polytomous logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). In models that were simultaneously adjusted for total (dietary plus supplements) calcium, total vitamin D and lactose, we observed a decreased overall risk of ovarian cancer with high intake of total calcium [Quartile 4 (Q4, >1,319 mg/day) vs. Quartile 1 (Q1, <655 mg/day), OR = 0.62, 95% CI = 0.49-0.79]; the inverse association was strongest for serous borderline and mucinous tumors. High intake of total vitamin D was not associated overall with ovarian cancer risk, but was inversely associated with risk of serous borderline (Q4, >559 IU/day vs. Q1, <164 IU/day, OR = 0.51, 95% CI = 0.34-0.76) and endometrioid tumors (Q4 vs. Q1, OR = 0.55, 95% CI = 0.39-0.80). We found no evidence that lactose intake influenced ovarian cancer risk or that risk varied by tumor aggressiveness in the analyses of intake of dairy foods and nutrients. The overall inverse association with high intake of calcium and the inverse associations of calcium and vitamin D with specific histological subtypes warrant further investigation.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. merritt@jimmy.harvard.edu

    , , ,

    Source

    International journal of cancer 132:5 2013 Mar 01 pg 1114-24

    MeSH

    Calcium, Dietary
    Case-Control Studies
    Dairy Products
    Diet
    Female
    Food
    Humans
    Lactose
    Logistic Models
    Middle Aged
    New England
    Odds Ratio
    Ovarian Neoplasms
    Risk
    Risk Factors
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    22740148

    Citation

    Merritt, Melissa A., et al. "Dairy Foods and Nutrients in Relation to Risk of Ovarian Cancer and Major Histological Subtypes." International Journal of Cancer, vol. 132, no. 5, 2013, pp. 1114-24.
    Merritt MA, Cramer DW, Vitonis AF, et al. Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes. Int J Cancer. 2013;132(5):1114-24.
    Merritt, M. A., Cramer, D. W., Vitonis, A. F., Titus, L. J., & Terry, K. L. (2013). Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes. International Journal of Cancer, 132(5), pp. 1114-24. doi:10.1002/ijc.27701.
    Merritt MA, et al. Dairy Foods and Nutrients in Relation to Risk of Ovarian Cancer and Major Histological Subtypes. Int J Cancer. 2013 Mar 1;132(5):1114-24. PubMed PMID: 22740148.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes. AU - Merritt,Melissa A, AU - Cramer,Daniel W, AU - Vitonis,Allison F, AU - Titus,Linda J, AU - Terry,Kathryn L, Y1 - 2012/07/24/ PY - 2012/02/09/received PY - 2012/06/11/accepted PY - 2012/6/29/entrez PY - 2012/6/29/pubmed PY - 2013/5/23/medline SP - 1114 EP - 24 JF - International journal of cancer JO - Int. J. Cancer VL - 132 IS - 5 N2 - Inconsistent results for the role of dairy food intake in relation to ovarian cancer risk may reflect the potential adverse effects of lactose, which has been hypothesized to increase gonadotropin levels, and the beneficial antiproliferative effects of calcium and vitamin D. Using data from the New England case-control study (1,909 cases and 1,989 controls), we examined dairy foods and nutrients in relation to risk of ovarian cancer overall, histological subtypes and rapidly fatal versus less aggressive disease. We used logistic regression and polytomous logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). In models that were simultaneously adjusted for total (dietary plus supplements) calcium, total vitamin D and lactose, we observed a decreased overall risk of ovarian cancer with high intake of total calcium [Quartile 4 (Q4, >1,319 mg/day) vs. Quartile 1 (Q1, <655 mg/day), OR = 0.62, 95% CI = 0.49-0.79]; the inverse association was strongest for serous borderline and mucinous tumors. High intake of total vitamin D was not associated overall with ovarian cancer risk, but was inversely associated with risk of serous borderline (Q4, >559 IU/day vs. Q1, <164 IU/day, OR = 0.51, 95% CI = 0.34-0.76) and endometrioid tumors (Q4 vs. Q1, OR = 0.55, 95% CI = 0.39-0.80). We found no evidence that lactose intake influenced ovarian cancer risk or that risk varied by tumor aggressiveness in the analyses of intake of dairy foods and nutrients. The overall inverse association with high intake of calcium and the inverse associations of calcium and vitamin D with specific histological subtypes warrant further investigation. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/22740148/Dairy_foods_and_nutrients_in_relation_to_risk_of_ovarian_cancer_and_major_histological_subtypes_ L2 - https://doi.org/10.1002/ijc.27701 DB - PRIME DP - Unbound Medicine ER -