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Vegetables, fruit and risk of non-gallstone-related acute pancreatitis: a population-based prospective cohort study.
Gut. 2013 Aug; 62(8):1187-92.Gut

Abstract

OBJECTIVE

To examine the association of vegetable and fruit consumption with the risk of non-gallstone-related acute pancreatitis.

DESIGN

A population-based prospective cohort of 80,019 women and men, aged 46-84 years, completed a food-frequency questionnaire at baseline and was followed up for incidence of non-gallstone-related acute pancreatitis from 1 January 1998 to 31 December 2009. Participants were categorised into quintiles according to consumption of vegetables and consumption of fruit. Cox proportional hazards models were used to estimate RRs and 95% CIs.

RESULTS

In total, 320 incident cases (216 men and 104 women) with non-gallstone-related acute pancreatitis were identified during 12 years of follow-up (891,136 person-years). After adjustment for potential confounders, the authors observed a significant inverse linear dose-response association between vegetable consumption and risk of non-gallstone-related acute pancreatitis; every two additional servings per day were associated with 17% risk reduction (RR=0.83; 95% CI 0.70 to 0.98; p=0.03). Among participants consuming >1 drink of alcohol per day and among those with body mass index ≥25 kg/m2, the RR for the highest compared with the lowest quintile of vegetable consumption was 0.29 (95% CI 0.13 to 0.67) and 0.49 (95% CI 0.29 to 0.85), respectively. Fruit consumption was not significantly associated with the risk of non-gallstone-related acute pancreatitis; the RR comparing extreme quintiles of consumption was 1.20 (95% CI 0.81 to 1.78).

CONCLUSIONS

Vegetable consumption, but not fruit consumption, may play a role in the prevention of non-gallstone-related acute pancreatitis.

Authors+Show Affiliations

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden. viktor.oskarsson@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22740517

Citation

Oskarsson, Viktor, et al. "Vegetables, Fruit and Risk of Non-gallstone-related Acute Pancreatitis: a Population-based Prospective Cohort Study." Gut, vol. 62, no. 8, 2013, pp. 1187-92.
Oskarsson V, Sadr-Azodi O, Orsini N, et al. Vegetables, fruit and risk of non-gallstone-related acute pancreatitis: a population-based prospective cohort study. Gut. 2013;62(8):1187-92.
Oskarsson, V., Sadr-Azodi, O., Orsini, N., Andrén-Sandberg, Å., & Wolk, A. (2013). Vegetables, fruit and risk of non-gallstone-related acute pancreatitis: a population-based prospective cohort study. Gut, 62(8), 1187-92. https://doi.org/10.1136/gutjnl-2012-302521
Oskarsson V, et al. Vegetables, Fruit and Risk of Non-gallstone-related Acute Pancreatitis: a Population-based Prospective Cohort Study. Gut. 2013;62(8):1187-92. PubMed PMID: 22740517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vegetables, fruit and risk of non-gallstone-related acute pancreatitis: a population-based prospective cohort study. AU - Oskarsson,Viktor, AU - Sadr-Azodi,Omid, AU - Orsini,Nicola, AU - Andrén-Sandberg,Åke, AU - Wolk,Alicja, Y1 - 2012/06/27/ PY - 2012/6/29/entrez PY - 2012/6/29/pubmed PY - 2013/9/10/medline KW - Acute pancreatitis KW - abdominal surgery KW - cohort studies KW - diet KW - epidemiology KW - nutrition KW - prospective SP - 1187 EP - 92 JF - Gut JO - Gut VL - 62 IS - 8 N2 - OBJECTIVE: To examine the association of vegetable and fruit consumption with the risk of non-gallstone-related acute pancreatitis. DESIGN: A population-based prospective cohort of 80,019 women and men, aged 46-84 years, completed a food-frequency questionnaire at baseline and was followed up for incidence of non-gallstone-related acute pancreatitis from 1 January 1998 to 31 December 2009. Participants were categorised into quintiles according to consumption of vegetables and consumption of fruit. Cox proportional hazards models were used to estimate RRs and 95% CIs. RESULTS: In total, 320 incident cases (216 men and 104 women) with non-gallstone-related acute pancreatitis were identified during 12 years of follow-up (891,136 person-years). After adjustment for potential confounders, the authors observed a significant inverse linear dose-response association between vegetable consumption and risk of non-gallstone-related acute pancreatitis; every two additional servings per day were associated with 17% risk reduction (RR=0.83; 95% CI 0.70 to 0.98; p=0.03). Among participants consuming >1 drink of alcohol per day and among those with body mass index ≥25 kg/m2, the RR for the highest compared with the lowest quintile of vegetable consumption was 0.29 (95% CI 0.13 to 0.67) and 0.49 (95% CI 0.29 to 0.85), respectively. Fruit consumption was not significantly associated with the risk of non-gallstone-related acute pancreatitis; the RR comparing extreme quintiles of consumption was 1.20 (95% CI 0.81 to 1.78). CONCLUSIONS: Vegetable consumption, but not fruit consumption, may play a role in the prevention of non-gallstone-related acute pancreatitis. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/22740517/Vegetables_fruit_and_risk_of_non_gallstone_related_acute_pancreatitis:_a_population_based_prospective_cohort_study_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&pmid=22740517 DB - PRIME DP - Unbound Medicine ER -