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Spider-venom peptides as bioinsecticides.
Toxins (Basel). 2012 03; 4(3):191-227.T

Abstract

Over 10,000 arthropod species are currently considered to be pest organisms. They are estimated to contribute to the destruction of ~14% of the world's annual crop production and transmit many pathogens. Presently, arthropod pests of agricultural and health significance are controlled predominantly through the use of chemical insecticides. Unfortunately, the widespread use of these agrochemicals has resulted in genetic selection pressure that has led to the development of insecticide-resistant arthropods, as well as concerns over human health and the environment. Bioinsecticides represent a new generation of insecticides that utilise organisms or their derivatives (e.g., transgenic plants, recombinant baculoviruses, toxin-fusion proteins and peptidomimetics) and show promise as environmentally-friendly alternatives to conventional agrochemicals. Spider-venom peptides are now being investigated as potential sources of bioinsecticides. With an estimated 100,000 species, spiders are one of the most successful arthropod predators. Their venom has proven to be a rich source of hyperstable insecticidal mini-proteins that cause insect paralysis or lethality through the modulation of ion channels, receptors and enzymes. Many newly characterized insecticidal spider toxins target novel sites in insects. Here we review the structure and pharmacology of these toxins and discuss the potential of this vast peptide library for the discovery of novel bioinsecticides.

Authors+Show Affiliations

Neurotoxin Research Group, School of Medical & Molecular Biosciences, University of Technology, Sydney, NSW, Australia. monique.windley@student.uts.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22741062

Citation

Windley, Monique J., et al. "Spider-venom Peptides as Bioinsecticides." Toxins, vol. 4, no. 3, 2012, pp. 191-227.
Windley MJ, Herzig V, Dziemborowicz SA, et al. Spider-venom peptides as bioinsecticides. Toxins (Basel). 2012;4(3):191-227.
Windley, M. J., Herzig, V., Dziemborowicz, S. A., Hardy, M. C., King, G. F., & Nicholson, G. M. (2012). Spider-venom peptides as bioinsecticides. Toxins, 4(3), 191-227. https://doi.org/10.3390/toxins4030191
Windley MJ, et al. Spider-venom Peptides as Bioinsecticides. Toxins (Basel). 2012;4(3):191-227. PubMed PMID: 22741062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spider-venom peptides as bioinsecticides. AU - Windley,Monique J, AU - Herzig,Volker, AU - Dziemborowicz,Sławomir A, AU - Hardy,Margaret C, AU - King,Glenn F, AU - Nicholson,Graham M, Y1 - 2012/03/22/ PY - 2012/01/31/received PY - 2012/03/07/revised PY - 2012/03/15/accepted PY - 2012/6/29/entrez PY - 2012/6/29/pubmed PY - 2012/12/10/medline KW - bioinsecticides KW - cystine knot KW - insecticidal KW - peptide KW - pest control KW - spider venom SP - 191 EP - 227 JF - Toxins JO - Toxins (Basel) VL - 4 IS - 3 N2 - Over 10,000 arthropod species are currently considered to be pest organisms. They are estimated to contribute to the destruction of ~14% of the world's annual crop production and transmit many pathogens. Presently, arthropod pests of agricultural and health significance are controlled predominantly through the use of chemical insecticides. Unfortunately, the widespread use of these agrochemicals has resulted in genetic selection pressure that has led to the development of insecticide-resistant arthropods, as well as concerns over human health and the environment. Bioinsecticides represent a new generation of insecticides that utilise organisms or their derivatives (e.g., transgenic plants, recombinant baculoviruses, toxin-fusion proteins and peptidomimetics) and show promise as environmentally-friendly alternatives to conventional agrochemicals. Spider-venom peptides are now being investigated as potential sources of bioinsecticides. With an estimated 100,000 species, spiders are one of the most successful arthropod predators. Their venom has proven to be a rich source of hyperstable insecticidal mini-proteins that cause insect paralysis or lethality through the modulation of ion channels, receptors and enzymes. Many newly characterized insecticidal spider toxins target novel sites in insects. Here we review the structure and pharmacology of these toxins and discuss the potential of this vast peptide library for the discovery of novel bioinsecticides. SN - 2072-6651 UR - https://www.unboundmedicine.com/medline/citation/22741062/Spider_venom_peptides_as_bioinsecticides_ L2 - http://www.mdpi.com/resolver?pii=toxins4030191 DB - PRIME DP - Unbound Medicine ER -