Citation
Dunkel, Petra, et al. "Clinical Utility of Neuroprotective Agents in Neurodegenerative Diseases: Current Status of Drug Development for Alzheimer's, Parkinson's and Huntington's Diseases, and Amyotrophic Lateral Sclerosis." Expert Opinion On Investigational Drugs, vol. 21, no. 9, 2012, pp. 1267-308.
Dunkel P, Chai CL, Sperlágh B, et al. Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis. Expert Opin Investig Drugs. 2012;21(9):1267-308.
Dunkel, P., Chai, C. L., Sperlágh, B., Huleatt, P. B., & Mátyus, P. (2012). Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis. Expert Opinion On Investigational Drugs, 21(9), 1267-308. https://doi.org/10.1517/13543784.2012.703178
Dunkel P, et al. Clinical Utility of Neuroprotective Agents in Neurodegenerative Diseases: Current Status of Drug Development for Alzheimer's, Parkinson's and Huntington's Diseases, and Amyotrophic Lateral Sclerosis. Expert Opin Investig Drugs. 2012;21(9):1267-308. PubMed PMID: 22741814.
TY - JOUR
T1 - Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.
AU - Dunkel,Petra,
AU - Chai,Christina Ll,
AU - Sperlágh,Beáta,
AU - Huleatt,Paul B,
AU - Mátyus,Péter,
Y1 - 2012/06/28/
PY - 2012/6/30/entrez
PY - 2012/6/30/pubmed
PY - 2013/1/5/medline
SP - 1267
EP - 308
JF - Expert opinion on investigational drugs
JO - Expert Opin Investig Drugs
VL - 21
IS - 9
N2 - INTRODUCTION: According to the definition of the Committee to Identify Neuroprotective Agents in Parkinson's Disease (CINAPS), "neuroprotection would be any intervention that favourably influences the disease process or underlying pathogenesis to produce enduring benefits for patients" [Meissner W, et al. Trends Pharmacol Sci 2004;25:249-253]. Preferably, neuroprotective agents should be used before or eventually during the prodromal phase of the diseases that could start decades before the appearance of symptoms. Although several symptomatic drugs are available, a disease-modifying agent is still elusive. AREAS COVERED: The aim of the present review is to give an overview of neuroprotective agents being currently investigated for the treatment of AD, PD, HD and ALS in clinical phases. EXPERT OPINION: Development of effective neuroprotective therapies resulting in clinically meaningful results is hampered by several factors in all research stages, both conceptual and methodological. Novel solutions might be offered by evaluation of new targets throughout clinical studies, therapies emerging from drug repositioning approaches, multi-target approaches and network pharmacology.
SN - 1744-7658
UR - https://www.unboundmedicine.com/medline/citation/22741814/Clinical_utility_of_neuroprotective_agents_in_neurodegenerative_diseases:_current_status_of_drug_development_for_Alzheimer's_Parkinson's_and_Huntington's_diseases_and_amyotrophic_lateral_sclerosis_
L2 - https://www.tandfonline.com/doi/full/10.1517/13543784.2012.703178
DB - PRIME
DP - Unbound Medicine
ER -