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Vitamin D supplementation, moderate sun exposure, and control of immune diseases.
Discov Med 2012; 13(73):397-404DM

Abstract

There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes. This has been driven mainly by observational studies linking vitamin D deficiency and insufficiency with increased prevalence of autoimmune and other diseases driven by immune processes. Randomized controlled trials of vitamin D supplementation to treat these (and other) diseases have been disappointing. This review examines the evidence that circulating vitamin D levels provide a surrogate measure of sun exposure and that it is the other molecules and pathways induced by sun exposure, rather than vitamin D-driven processes, that explain many of the benefits often attributed to vitamin D.

Authors+Show Affiliations

Department of Inflammation, Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia 6008, Australia. prueh@ichr.uwa.edu.au

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22742645

Citation

Hart, Prue H.. "Vitamin D Supplementation, Moderate Sun Exposure, and Control of Immune Diseases." Discovery Medicine, vol. 13, no. 73, 2012, pp. 397-404.
Hart PH. Vitamin D supplementation, moderate sun exposure, and control of immune diseases. Discov Med. 2012;13(73):397-404.
Hart, P. H. (2012). Vitamin D supplementation, moderate sun exposure, and control of immune diseases. Discovery Medicine, 13(73), pp. 397-404.
Hart PH. Vitamin D Supplementation, Moderate Sun Exposure, and Control of Immune Diseases. Discov Med. 2012;13(73):397-404. PubMed PMID: 22742645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation, moderate sun exposure, and control of immune diseases. A1 - Hart,Prue H, PY - 2012/6/30/entrez PY - 2012/6/30/pubmed PY - 2012/10/23/medline SP - 397 EP - 404 JF - Discovery medicine JO - Discov Med VL - 13 IS - 73 N2 - There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes. This has been driven mainly by observational studies linking vitamin D deficiency and insufficiency with increased prevalence of autoimmune and other diseases driven by immune processes. Randomized controlled trials of vitamin D supplementation to treat these (and other) diseases have been disappointing. This review examines the evidence that circulating vitamin D levels provide a surrogate measure of sun exposure and that it is the other molecules and pathways induced by sun exposure, rather than vitamin D-driven processes, that explain many of the benefits often attributed to vitamin D. SN - 1944-7930 UR - https://www.unboundmedicine.com/medline/citation/22742645/Vitamin_D_supplementation_moderate_sun_exposure_and_control_of_immune_diseases_ L2 - http://www.discoverymedicine.com/Prue-H-Hart/2012/06/14/vitamin-d-supplementation-moderate-sun-exposure-and-control-of-immune-diseases/ DB - PRIME DP - Unbound Medicine ER -