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Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis.
J Gastroenterol Hepatol 2012; 27(11):1695-704JG

Abstract

BACKGROUND AND AIM

Although the Psychometric Hepatic Encephalopathy Score (PHES) for the diagnosis of minimal hepatic encephalopathy (MHE) has been validated in several countries, further validation is required for its use in different populations. The aims of this study were thus to standardize the PHES in a healthy Korean population and evaluate the prevalence of MHE among Korean patients with liver cirrhosis.

METHODS

Two-hundred healthy subjects without evidence of liver disease and 160 patients with liver cirrhosis without overt HE were included. Blood sampling for routine laboratory tests and determination of venous ammonia concentration was performed on the day of PHES neuropsychological testing.

RESULTS

The age and education years of the control group were 41 ± 13 years and 13 ± 3 years, respectively; 100 of the subjects (50.0%) were men. The PHES for the control group was -0.31 ± 2.06 and the normal range was thus set at > -5 points. The age and education years of the liver cirrhosis group were 55 ± 8 and 11 ± 4 years, respectively; 102 of those in this group (63.8%) were men. Of the liver cirrhosis patients, 129 (80.6%), 21 (13.1%), and 10 (6.3%) had Child-Pugh grades A, B, and C, respectively. The PHES of the liver cirrhosis group was -2.94 ± 3.39. MHE was diagnosed in 41 patients (25.6%), of which 26 (20.2%), nine (42.9%), and six (60.0%) had Child-Pugh grades A, B, and C, respectively.

CONCLUSIONS

The PHES was useful for detecting patients with MHE. A significant proportion of Korean patients with liver cirrhosis suffer from MHE.

Authors+Show Affiliations

Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22743001

Citation

Seo, Yeon Seok, et al. "Psychometric Hepatic Encephalopathy Score for the Detection of Minimal Hepatic Encephalopathy in Korean Patients With Liver Cirrhosis." Journal of Gastroenterology and Hepatology, vol. 27, no. 11, 2012, pp. 1695-704.
Seo YS, Yim SY, Jung JY, et al. Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis. J Gastroenterol Hepatol. 2012;27(11):1695-704.
Seo, Y. S., Yim, S. Y., Jung, J. Y., Kim, C. H., Kim, J. D., Keum, B., ... Um, S. H. (2012). Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis. Journal of Gastroenterology and Hepatology, 27(11), pp. 1695-704. doi:10.1111/j.1440-1746.2012.07217.x.
Seo YS, et al. Psychometric Hepatic Encephalopathy Score for the Detection of Minimal Hepatic Encephalopathy in Korean Patients With Liver Cirrhosis. J Gastroenterol Hepatol. 2012;27(11):1695-704. PubMed PMID: 22743001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis. AU - Seo,Yeon Seok, AU - Yim,Sun Young, AU - Jung,Jin Yong, AU - Kim,Chang Ha, AU - Kim,Jin Dong, AU - Keum,Bora, AU - An,Hyonggin, AU - Yim,Hyung Joon, AU - Lee,Hong Sik, AU - Kim,Chang Duck, AU - Ryu,Ho Sang, AU - Um,Soon Ho, PY - 2012/6/30/entrez PY - 2012/6/30/pubmed PY - 2013/5/10/medline SP - 1695 EP - 704 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 27 IS - 11 N2 - BACKGROUND AND AIM: Although the Psychometric Hepatic Encephalopathy Score (PHES) for the diagnosis of minimal hepatic encephalopathy (MHE) has been validated in several countries, further validation is required for its use in different populations. The aims of this study were thus to standardize the PHES in a healthy Korean population and evaluate the prevalence of MHE among Korean patients with liver cirrhosis. METHODS: Two-hundred healthy subjects without evidence of liver disease and 160 patients with liver cirrhosis without overt HE were included. Blood sampling for routine laboratory tests and determination of venous ammonia concentration was performed on the day of PHES neuropsychological testing. RESULTS: The age and education years of the control group were 41 ± 13 years and 13 ± 3 years, respectively; 100 of the subjects (50.0%) were men. The PHES for the control group was -0.31 ± 2.06 and the normal range was thus set at > -5 points. The age and education years of the liver cirrhosis group were 55 ± 8 and 11 ± 4 years, respectively; 102 of those in this group (63.8%) were men. Of the liver cirrhosis patients, 129 (80.6%), 21 (13.1%), and 10 (6.3%) had Child-Pugh grades A, B, and C, respectively. The PHES of the liver cirrhosis group was -2.94 ± 3.39. MHE was diagnosed in 41 patients (25.6%), of which 26 (20.2%), nine (42.9%), and six (60.0%) had Child-Pugh grades A, B, and C, respectively. CONCLUSIONS: The PHES was useful for detecting patients with MHE. A significant proportion of Korean patients with liver cirrhosis suffer from MHE. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/22743001/Psychometric_hepatic_encephalopathy_score_for_the_detection_of_minimal_hepatic_encephalopathy_in_Korean_patients_with_liver_cirrhosis_ L2 - https://doi.org/10.1111/j.1440-1746.2012.07217.x DB - PRIME DP - Unbound Medicine ER -