Tags

Type your tag names separated by a space and hit enter

Heat-evoked experimental pain induces long-term potentiation-like plasticity in human primary motor cortex.
Cereb Cortex. 2013 Aug; 23(8):1942-51.CC

Abstract

We designed a new paired associative stimulation (PAS) protocol that combines experimental pain evoked by laser stimuli and transcranial magnetic stimulation (TMS) (Laser-PAS) to primary motor cortex (M1). We tested in healthy subjects whether Laser-PAS elicits cortical plasticity as reflected by long-term changes in motor-evoked potentials (MEPs) (after-effects). In separate experiments, we examined numerous variables including changes induced by varying the interstimulus intervals (ISIs) and Laser-PAS-induced changes in target and non-target muscle MEPs. We measured MEPs after repetitive laser or TMS (rTMS) pulses, and compared magnetic- and electric (TES)-induced MEPs. We tested MEPs after applying Laser-PAS with laser pulses ipsilaterally to M1. Finally, we studied subjects receiving an N-methyl-D-aspartate (NMDA) receptor antagonist (memantine) or placebo (α-lipoic acid). During Laser-PAS at the 50 ms ISI MEPs decreased, thereafter they increased for 60 min; other ISIs induced no after-effects. The after-effects remained restricted to the target muscle. Repetitive laser pulses and rTMS induced no after-effects. After Laser-PAS, TMS-induced MEPs increased, whereas TES-induced MEPs did not. Laser-PAS with laser pulses ipsilaterally to M1 left MEPs unchanged. Memantine, but not α-lipoic acid, abolished the after-effects. In conclusion, Laser-PAS elicits NMDA-dependent cortical plasticity and provides new insights into human pain-motor integration.

Authors+Show Affiliations

IRCCS Neuromed Institute, Sapienza University of Rome, 00185 Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22744704

Citation

Suppa, A, et al. "Heat-evoked Experimental Pain Induces Long-term Potentiation-like Plasticity in Human Primary Motor Cortex." Cerebral Cortex (New York, N.Y. : 1991), vol. 23, no. 8, 2013, pp. 1942-51.
Suppa A, Biasiotta A, Belvisi D, et al. Heat-evoked experimental pain induces long-term potentiation-like plasticity in human primary motor cortex. Cereb Cortex. 2013;23(8):1942-51.
Suppa, A., Biasiotta, A., Belvisi, D., Marsili, L., La Cesa, S., Truini, A., Cruccu, G., & Berardelli, A. (2013). Heat-evoked experimental pain induces long-term potentiation-like plasticity in human primary motor cortex. Cerebral Cortex (New York, N.Y. : 1991), 23(8), 1942-51. https://doi.org/10.1093/cercor/bhs182
Suppa A, et al. Heat-evoked Experimental Pain Induces Long-term Potentiation-like Plasticity in Human Primary Motor Cortex. Cereb Cortex. 2013;23(8):1942-51. PubMed PMID: 22744704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heat-evoked experimental pain induces long-term potentiation-like plasticity in human primary motor cortex. AU - Suppa,A, AU - Biasiotta,A, AU - Belvisi,D, AU - Marsili,L, AU - La Cesa,S, AU - Truini,A, AU - Cruccu,G, AU - Berardelli,A, Y1 - 2012/06/28/ PY - 2012/6/30/entrez PY - 2012/6/30/pubmed PY - 2014/2/27/medline KW - TMS KW - laser-evoked potentials KW - pain-motor integration KW - primary motor cortex KW - spike timing-dependent plasticity SP - 1942 EP - 51 JF - Cerebral cortex (New York, N.Y. : 1991) JO - Cereb. Cortex VL - 23 IS - 8 N2 - We designed a new paired associative stimulation (PAS) protocol that combines experimental pain evoked by laser stimuli and transcranial magnetic stimulation (TMS) (Laser-PAS) to primary motor cortex (M1). We tested in healthy subjects whether Laser-PAS elicits cortical plasticity as reflected by long-term changes in motor-evoked potentials (MEPs) (after-effects). In separate experiments, we examined numerous variables including changes induced by varying the interstimulus intervals (ISIs) and Laser-PAS-induced changes in target and non-target muscle MEPs. We measured MEPs after repetitive laser or TMS (rTMS) pulses, and compared magnetic- and electric (TES)-induced MEPs. We tested MEPs after applying Laser-PAS with laser pulses ipsilaterally to M1. Finally, we studied subjects receiving an N-methyl-D-aspartate (NMDA) receptor antagonist (memantine) or placebo (α-lipoic acid). During Laser-PAS at the 50 ms ISI MEPs decreased, thereafter they increased for 60 min; other ISIs induced no after-effects. The after-effects remained restricted to the target muscle. Repetitive laser pulses and rTMS induced no after-effects. After Laser-PAS, TMS-induced MEPs increased, whereas TES-induced MEPs did not. Laser-PAS with laser pulses ipsilaterally to M1 left MEPs unchanged. Memantine, but not α-lipoic acid, abolished the after-effects. In conclusion, Laser-PAS elicits NMDA-dependent cortical plasticity and provides new insights into human pain-motor integration. SN - 1460-2199 UR - https://www.unboundmedicine.com/medline/citation/22744704/Heat_evoked_experimental_pain_induces_long_term_potentiation_like_plasticity_in_human_primary_motor_cortex_ L2 - https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhs182 DB - PRIME DP - Unbound Medicine ER -