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Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis.
Arthritis Care Res (Hoboken) 2012; 64(12):1829-36AC

Abstract

OBJECTIVE

Vitamin D has immunomodulatory properties with potential etiologic implications for autoimmune diseases. The relevant exposure time during which vitamin D may influence disease risk is unknown. Our objective was to examine the relationship between reported vitamin D intake during adolescence and adult-onset rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) incidence in prospective cohort studies of women, the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII).

METHODS

Food frequency questionnaires concerning high school diet completed by 73,629 NHS (1986) and 45,544 NHSII (1998) participants were used to calculate nutrient intakes during adolescence. Incident RA and SLE cases prior to 2006 (NHS) and 2007 (NHSII) were confirmed by medical record review. Cox proportional hazards models calculated relative risks and 95% confidence intervals of incident RA and SLE according to quintile cutoffs of vitamin D intake. Age- and calorie-adjusted and multivariable-adjusted (including sun exposure factors) analyses were completed. Random-effects models were used to meta-analyze estimates of association from the 2 cohorts.

RESULTS

Incident RA was confirmed in 652 NHS and 148 NHSII participants and SLE was confirmed in 122 NHS and 54 NHSII participants over a mean followup time of 351 months (NHS) and 209 months (NHSII). Age- and calorie-adjusted and multivariable-adjusted models did not show significant associations between adolescent vitamin D intake and risk of adult-onset RA or SLE.

CONCLUSION

We did not find associations between adolescent dietary vitamin D intake and adult RA or SLE risk among NHS and NHSII women, suggesting that other time periods during the life course should be studied.

Authors+Show Affiliations

Harvard School of Public Health and Brigham and Women's Hospital, Boston, MA 02115, USA. lhiraki@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22744978

Citation

Hiraki, Linda T., et al. "Dietary Intake of Vitamin D During Adolescence and Risk of Adult-onset Systemic Lupus Erythematosus and Rheumatoid Arthritis." Arthritis Care & Research, vol. 64, no. 12, 2012, pp. 1829-36.
Hiraki LT, Munger KL, Costenbader KH, et al. Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012;64(12):1829-36.
Hiraki, L. T., Munger, K. L., Costenbader, K. H., & Karlson, E. W. (2012). Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis. Arthritis Care & Research, 64(12), pp. 1829-36. doi:10.1002/acr.21776.
Hiraki LT, et al. Dietary Intake of Vitamin D During Adolescence and Risk of Adult-onset Systemic Lupus Erythematosus and Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2012;64(12):1829-36. PubMed PMID: 22744978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis. AU - Hiraki,Linda T, AU - Munger,Kassandra L, AU - Costenbader,Karen H, AU - Karlson,Elizabeth W, PY - 2012/02/23/received PY - 2012/06/15/accepted PY - 2012/6/30/entrez PY - 2012/6/30/pubmed PY - 2013/1/31/medline SP - 1829 EP - 36 JF - Arthritis care & research JO - Arthritis Care Res (Hoboken) VL - 64 IS - 12 N2 - OBJECTIVE: Vitamin D has immunomodulatory properties with potential etiologic implications for autoimmune diseases. The relevant exposure time during which vitamin D may influence disease risk is unknown. Our objective was to examine the relationship between reported vitamin D intake during adolescence and adult-onset rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) incidence in prospective cohort studies of women, the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII). METHODS: Food frequency questionnaires concerning high school diet completed by 73,629 NHS (1986) and 45,544 NHSII (1998) participants were used to calculate nutrient intakes during adolescence. Incident RA and SLE cases prior to 2006 (NHS) and 2007 (NHSII) were confirmed by medical record review. Cox proportional hazards models calculated relative risks and 95% confidence intervals of incident RA and SLE according to quintile cutoffs of vitamin D intake. Age- and calorie-adjusted and multivariable-adjusted (including sun exposure factors) analyses were completed. Random-effects models were used to meta-analyze estimates of association from the 2 cohorts. RESULTS: Incident RA was confirmed in 652 NHS and 148 NHSII participants and SLE was confirmed in 122 NHS and 54 NHSII participants over a mean followup time of 351 months (NHS) and 209 months (NHSII). Age- and calorie-adjusted and multivariable-adjusted models did not show significant associations between adolescent vitamin D intake and risk of adult-onset RA or SLE. CONCLUSION: We did not find associations between adolescent dietary vitamin D intake and adult RA or SLE risk among NHS and NHSII women, suggesting that other time periods during the life course should be studied. SN - 2151-4658 UR - https://www.unboundmedicine.com/medline/citation/22744978/Dietary_intake_of_vitamin_D_during_adolescence_and_risk_of_adult_onset_systemic_lupus_erythematosus_and_rheumatoid_arthritis_ L2 - https://doi.org/10.1002/acr.21776 DB - PRIME DP - Unbound Medicine ER -