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Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter.
J Psychiatry Neurosci. 2012 Sep; 37(5):305-12.JP

Abstract

BACKGROUND

Several patterns of grey and white matter changes have been separately described in young adults with first-episode psychosis. Concomitant investigation of grey and white matter densities in patients with first-episode psychosis without other psychiatric comorbidities that include all relevant imaging markers could provide clues to the neurodevelopmental hypothesis in schizophrenia.

METHODS

We recruited patients with first-episode psychosis diagnosed according to the DSM-IV-TR and matched controls. All participants underwent magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis and mean diffusivity voxel-based analysis (VBA) were used for grey matter data. Fractional anisotropy and axial, radial and mean diffusivity were analyzed using tract-based spatial statistics (TBSS) for white matter data.

RESULTS

We included 15 patients and 16 controls. The mean diffusivity VBA showed significantly greater mean diffusivity in the first-episode psychosis than in the control group in the lingual gyrus bilaterally, the occipital fusiform gyrus bilaterally, the right lateral occipital gyrus and the right inferior temporal gyrus. Moreover, the TBSS analysis revealed a lower fractional anisotropy in the first-episode psychosis than in the control group in the genu of the corpus callosum, minor forceps, corticospinal tract, right superior longitudinal fasciculus, left middle cerebellar peduncle, left inferior longitudinal fasciculus and the posterior part of the fronto-occipital fasciculus. This analysis also revealed greater radial diffusivity in the first-episode psychosis than in the control group in the right corticospinal tract, right superior longitudinal fasciculus and left middle cerebellar peduncle.

LIMITATIONS

The modest sample size and the absence of women in our series could limit the impact of our results.

CONCLUSION

Our results highlight the structural vulnerability of grey matter in posterior areas of the brain among young adult male patients with first-episode psychosis. Moreover, the concomitant greater radial diffusivity within several regions already revealed by the fractional anisotropy analysis supports the idea of a late myelination in patients with first-episode psychosis.

Authors+Show Affiliations

Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22748698

Citation

Ruef, Anne, et al. "Magnetic Resonance Imaging Correlates of First-episode Psychosis in Young Adult Male Patients: Combined Analysis of Grey and White Matter." Journal of Psychiatry & Neuroscience : JPN, vol. 37, no. 5, 2012, pp. 305-12.
Ruef A, Curtis L, Moy G, et al. Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter. J Psychiatry Neurosci. 2012;37(5):305-12.
Ruef, A., Curtis, L., Moy, G., Bessero, S., Badan Bâ, M., Lazeyras, F., Lövblad, K. O., Haller, S., Malafosse, A., Giannakopoulos, P., & Merlo, M. (2012). Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter. Journal of Psychiatry & Neuroscience : JPN, 37(5), 305-12. https://doi.org/10.1503/jpn.110057
Ruef A, et al. Magnetic Resonance Imaging Correlates of First-episode Psychosis in Young Adult Male Patients: Combined Analysis of Grey and White Matter. J Psychiatry Neurosci. 2012;37(5):305-12. PubMed PMID: 22748698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter. AU - Ruef,Anne, AU - Curtis,Logos, AU - Moy,Guenael, AU - Bessero,Severine, AU - Badan Bâ,Maryse, AU - Lazeyras,François, AU - Lövblad,Karl-Olof, AU - Haller,Sven, AU - Malafosse,Alain, AU - Giannakopoulos,Panteleimon, AU - Merlo,Marco, PY - 2012/7/4/entrez PY - 2012/7/4/pubmed PY - 2013/1/24/medline SP - 305 EP - 12 JF - Journal of psychiatry & neuroscience : JPN JO - J Psychiatry Neurosci VL - 37 IS - 5 N2 - BACKGROUND: Several patterns of grey and white matter changes have been separately described in young adults with first-episode psychosis. Concomitant investigation of grey and white matter densities in patients with first-episode psychosis without other psychiatric comorbidities that include all relevant imaging markers could provide clues to the neurodevelopmental hypothesis in schizophrenia. METHODS: We recruited patients with first-episode psychosis diagnosed according to the DSM-IV-TR and matched controls. All participants underwent magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis and mean diffusivity voxel-based analysis (VBA) were used for grey matter data. Fractional anisotropy and axial, radial and mean diffusivity were analyzed using tract-based spatial statistics (TBSS) for white matter data. RESULTS: We included 15 patients and 16 controls. The mean diffusivity VBA showed significantly greater mean diffusivity in the first-episode psychosis than in the control group in the lingual gyrus bilaterally, the occipital fusiform gyrus bilaterally, the right lateral occipital gyrus and the right inferior temporal gyrus. Moreover, the TBSS analysis revealed a lower fractional anisotropy in the first-episode psychosis than in the control group in the genu of the corpus callosum, minor forceps, corticospinal tract, right superior longitudinal fasciculus, left middle cerebellar peduncle, left inferior longitudinal fasciculus and the posterior part of the fronto-occipital fasciculus. This analysis also revealed greater radial diffusivity in the first-episode psychosis than in the control group in the right corticospinal tract, right superior longitudinal fasciculus and left middle cerebellar peduncle. LIMITATIONS: The modest sample size and the absence of women in our series could limit the impact of our results. CONCLUSION: Our results highlight the structural vulnerability of grey matter in posterior areas of the brain among young adult male patients with first-episode psychosis. Moreover, the concomitant greater radial diffusivity within several regions already revealed by the fractional anisotropy analysis supports the idea of a late myelination in patients with first-episode psychosis. SN - 1488-2434 UR - https://www.unboundmedicine.com/medline/citation/22748698/Magnetic_resonance_imaging_correlates_of_first_episode_psychosis_in_young_adult_male_patients:_combined_analysis_of_grey_and_white_matter_ L2 - https://linkinghub.elsevier.com/retrieve/pii/10.1503/jpn.110057 DB - PRIME DP - Unbound Medicine ER -