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Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro.
Reprod Toxicol. 2012 Nov; 34(3):443-50.RT

Abstract

This study investigated the effects of antipsychotic drugs on heart function of gestational day (GD) 13 rat embryos in vitro since they all block the I(Kr)/hERG potassium ion channel in addition to their main pharmacological effect on neurotransmitters. The results showed that all the tested antipsychotic drugs caused bradycardia of the rat embryonic heart in a concentration-dependent manner. However, with the possible exception of haloperidol the tested drugs did not cause arrhythmias typically seen with the highly selective I(Kr)/hERG blocking drug dofetilide. For six of the eight drugs tested the effects on the embryonic rat heart were only seen at free drug concentrations that were much greater than those likely to occur in pregnant women taking antipsychotic medication. However, the safety margins for haloperidol and quetiapine were lower.

Authors+Show Affiliations

Department of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22750488

Citation

Gunnström, M, et al. "Antipsychotic Drugs Cause Bradycardia in GD 13 Rat Embryos in Vitro." Reproductive Toxicology (Elmsford, N.Y.), vol. 34, no. 3, 2012, pp. 443-50.
Gunnström M, Ababneh D, Webster WS, et al. Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro. Reprod Toxicol. 2012;34(3):443-50.
Gunnström, M., Ababneh, D., Webster, W. S., Oakes, D., & Ritchie, H. (2012). Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro. Reproductive Toxicology (Elmsford, N.Y.), 34(3), 443-50. https://doi.org/10.1016/j.reprotox.2012.06.008
Gunnström M, et al. Antipsychotic Drugs Cause Bradycardia in GD 13 Rat Embryos in Vitro. Reprod Toxicol. 2012;34(3):443-50. PubMed PMID: 22750488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro. AU - Gunnström,M, AU - Ababneh,D, AU - Webster,W S, AU - Oakes,D, AU - Ritchie,H, Y1 - 2012/06/28/ PY - 2012/02/20/received PY - 2012/05/30/revised PY - 2012/06/15/accepted PY - 2012/7/4/entrez PY - 2012/7/4/pubmed PY - 2013/1/25/medline SP - 443 EP - 50 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod. Toxicol. VL - 34 IS - 3 N2 - This study investigated the effects of antipsychotic drugs on heart function of gestational day (GD) 13 rat embryos in vitro since they all block the I(Kr)/hERG potassium ion channel in addition to their main pharmacological effect on neurotransmitters. The results showed that all the tested antipsychotic drugs caused bradycardia of the rat embryonic heart in a concentration-dependent manner. However, with the possible exception of haloperidol the tested drugs did not cause arrhythmias typically seen with the highly selective I(Kr)/hERG blocking drug dofetilide. For six of the eight drugs tested the effects on the embryonic rat heart were only seen at free drug concentrations that were much greater than those likely to occur in pregnant women taking antipsychotic medication. However, the safety margins for haloperidol and quetiapine were lower. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/22750488/Antipsychotic_drugs_cause_bradycardia_in_GD_13_rat_embryos_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(12)00234-1 DB - PRIME DP - Unbound Medicine ER -