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Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease.
J Alzheimers Dis. 2013; 33 Suppl 1:S87-100.JA

Abstract

The evidence that neurovascular dysfunction is an integral part of Alzheimer's disease (AD) pathogenesis has continued to emerge in the last decade. Changes in the brain vasculature have been shown to contribute to the onset and progression of the pathological processes associated with AD, such as microvascular reductions, blood brain barrier (BBB) breakdown, and faulty clearance of amyloid β-peptide (Aβ) from the brain. Herein, we review the role of the neurovascular unit and molecular mechanisms in cerebral vascular cells behind the pathogenesis of AD. In particular, we focus on molecular pathways within cerebral vascular cells and the systemic circulation that contribute to BBB dysfunction, brain hypoperfusion, and impaired clearance of Aβ from the brain. We aim to provide a summary of recent research findings implicated in neurovascular defects and faulty Aβ vascular clearance contributing to AD pathogenesis.

Authors+Show Affiliations

Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22751174

Citation

Sagare, Abhay P., et al. "Neurovascular Defects and Faulty Amyloid-β Vascular Clearance in Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 33 Suppl 1, 2013, pp. S87-100.
Sagare AP, Bell RD, Zlokovic BV. Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. J Alzheimers Dis. 2013;33 Suppl 1:S87-100.
Sagare, A. P., Bell, R. D., & Zlokovic, B. V. (2013). Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 33 Suppl 1, S87-100.
Sagare AP, Bell RD, Zlokovic BV. Neurovascular Defects and Faulty Amyloid-β Vascular Clearance in Alzheimer's Disease. J Alzheimers Dis. 2013;33 Suppl 1:S87-100. PubMed PMID: 22751174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. AU - Sagare,Abhay P, AU - Bell,Robert D, AU - Zlokovic,Berislav V, PY - 2012/7/4/entrez PY - 2012/7/4/pubmed PY - 2013/6/7/medline SP - S87 EP - 100 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 33 Suppl 1 N2 - The evidence that neurovascular dysfunction is an integral part of Alzheimer's disease (AD) pathogenesis has continued to emerge in the last decade. Changes in the brain vasculature have been shown to contribute to the onset and progression of the pathological processes associated with AD, such as microvascular reductions, blood brain barrier (BBB) breakdown, and faulty clearance of amyloid β-peptide (Aβ) from the brain. Herein, we review the role of the neurovascular unit and molecular mechanisms in cerebral vascular cells behind the pathogenesis of AD. In particular, we focus on molecular pathways within cerebral vascular cells and the systemic circulation that contribute to BBB dysfunction, brain hypoperfusion, and impaired clearance of Aβ from the brain. We aim to provide a summary of recent research findings implicated in neurovascular defects and faulty Aβ vascular clearance contributing to AD pathogenesis. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/22751174/Neurovascular_defects_and_faulty_amyloid_β_vascular_clearance_in_Alzheimer's_disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2012-129037 DB - PRIME DP - Unbound Medicine ER -