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Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study.
Can J Anaesth. 2012 Sep; 59(9):861-70.CJ

Abstract

PURPOSE

The optimal timing for starting renal replacement therapy (RRT) in patients with acute kidney injury (AKI) is unknown. Defining current practice is necessary to design interventional trials. We describe the current Canadian practice regarding the timing of RRT initiation for AKI.

METHODS

An observational study of patients undergoing RRT for AKI was undertaken at 11 intensive care units (ICUs) across Canada. Data were captured on demographics, clinical and laboratory findings, indications for RRT, and timing of RRT initiation.

RESULTS

Among 119 consecutive patients, the most common ICU admission diagnosis was sepsis/septic shock, occurring in 54%. At the time of RRT initiation, the median and interquartile range (IQR) serum creatinine level was 322 (221-432) μmol·L(-1). The mean (SD) values for other parameters were as follows: Sequential Organ Failure Assessment (SOFA) score 13.4 (4.1), pH 7.25 (0.15), potassium 4.6 (1.0) mmol·L(-1). Also, 64% fulfilled the serum creatinine-based criterion for Acute Kidney Injury Network (AKIN) stage 3. Severity of illness, measured using Acute Physiology and Chronic Health Evaluation (APACHE II) and SOFA scores, did not correlate with AKI severity as defined by the serum creatinine-based AKIN criteria. Median (IQR) time from hospital and ICU admission to the start of RRT was 2.0 (1.0-7.0) days and 1.0 (0-2.0) day, respectively.

CONCLUSION

Patients admitted to an ICU who were started on RRT generally had advanced AKI, high-grade illness severity, and multiorgan dysfunction. Also, they were started on RRT shortly after hospital presentation. We describe the current state of practice in Canada regarding the initiation of RRT for AKI in critically ill patients, which can inform the designs of future interventional trials.

Authors+Show Affiliations

Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22752716

Citation

Clark, Edward, et al. "Timing the Initiation of Renal Replacement Therapy for Acute Kidney Injury in Canadian Intensive Care Units: a Multicentre Observational Study." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 59, no. 9, 2012, pp. 861-70.
Clark E, Wald R, Levin A, et al. Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study. Can J Anaesth. 2012;59(9):861-70.
Clark, E., Wald, R., Levin, A., Bouchard, J., Adhikari, N. K., Hladunewich, M., Richardson, R. M., James, M. T., Walsh, M. W., House, A. A., Moist, L., Stollery, D. E., Burns, K. E., Friedrich, J. O., Barton, J., Lafrance, J. P., Pannu, N., & Bagshaw, S. M. (2012). Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 59(9), 861-70. https://doi.org/10.1007/s12630-012-9750-4
Clark E, et al. Timing the Initiation of Renal Replacement Therapy for Acute Kidney Injury in Canadian Intensive Care Units: a Multicentre Observational Study. Can J Anaesth. 2012;59(9):861-70. PubMed PMID: 22752716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study. AU - Clark,Edward, AU - Wald,Ron, AU - Levin,Adeera, AU - Bouchard,Josée, AU - Adhikari,Neill K J, AU - Hladunewich,Michelle, AU - Richardson,Robert M A, AU - James,Matthew T, AU - Walsh,Michael W, AU - House,Andrew A, AU - Moist,Louise, AU - Stollery,Daniel E, AU - Burns,Karen E A, AU - Friedrich,Jan O, AU - Barton,James, AU - Lafrance,Jean-Philippe, AU - Pannu,Neesh, AU - Bagshaw,Sean M, AU - ,, Y1 - 2012/06/30/ PY - 2012/03/22/received PY - 2012/06/20/accepted PY - 2012/7/4/entrez PY - 2012/7/4/pubmed PY - 2013/1/17/medline SP - 861 EP - 70 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 59 IS - 9 N2 - PURPOSE: The optimal timing for starting renal replacement therapy (RRT) in patients with acute kidney injury (AKI) is unknown. Defining current practice is necessary to design interventional trials. We describe the current Canadian practice regarding the timing of RRT initiation for AKI. METHODS: An observational study of patients undergoing RRT for AKI was undertaken at 11 intensive care units (ICUs) across Canada. Data were captured on demographics, clinical and laboratory findings, indications for RRT, and timing of RRT initiation. RESULTS: Among 119 consecutive patients, the most common ICU admission diagnosis was sepsis/septic shock, occurring in 54%. At the time of RRT initiation, the median and interquartile range (IQR) serum creatinine level was 322 (221-432) μmol·L(-1). The mean (SD) values for other parameters were as follows: Sequential Organ Failure Assessment (SOFA) score 13.4 (4.1), pH 7.25 (0.15), potassium 4.6 (1.0) mmol·L(-1). Also, 64% fulfilled the serum creatinine-based criterion for Acute Kidney Injury Network (AKIN) stage 3. Severity of illness, measured using Acute Physiology and Chronic Health Evaluation (APACHE II) and SOFA scores, did not correlate with AKI severity as defined by the serum creatinine-based AKIN criteria. Median (IQR) time from hospital and ICU admission to the start of RRT was 2.0 (1.0-7.0) days and 1.0 (0-2.0) day, respectively. CONCLUSION: Patients admitted to an ICU who were started on RRT generally had advanced AKI, high-grade illness severity, and multiorgan dysfunction. Also, they were started on RRT shortly after hospital presentation. We describe the current state of practice in Canada regarding the initiation of RRT for AKI in critically ill patients, which can inform the designs of future interventional trials. SN - 1496-8975 UR - https://www.unboundmedicine.com/medline/citation/22752716/Timing_the_initiation_of_renal_replacement_therapy_for_acute_kidney_injury_in_Canadian_intensive_care_units:_a_multicentre_observational_study_ L2 - https://doi.org/10.1007/s12630-012-9750-4 DB - PRIME DP - Unbound Medicine ER -