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Anxiolytic activity evaluation of four medicinal plants from Cameroon.
Afr J Tradit Complement Altern Med. 2011; 8(5 Suppl):130-9.AJ

Abstract

Afrormosia laxiflora (A. laxiflora), Chenopodium ambrosioides (C. ambrosioides), Microglossa pyrifolia (M. pyrifolia) and Mimosa pudica (M. pudica) are plants used in traditional medicine in Cameroon to treat insomnia, epilepsy, anxiety, and agitation. They were evaluated for their anxiolytic like activity in mice. Animal models (elevated plus maze and stress-induced hyperthermia tests) were used. The four plants showed anxiolytic activity. In stress-induced hyperthermia test, A. laxiflora, C. ambrosioides, M. pyrifolia and M. pudica significantly antagonised the increase of temperature. ΔT° decreased from 0.75°C in the control group to 0.36°C at the dose of 110 mg/kg for A. laxiflora; from 1°C in the control group to -1.1°C at the dose of 120 mg/kg for C. ambrosioides; from 1.7°C in the control group to 0.2°C at the dose of 128 mg/kg for M. pyrifolia and from 1.3°C in the control group to 0.5°C at the dose of 180 mg/kg for M. pudica. In the elevated plus maze test, the four plants increased the number of entries into, percentage of entries into, and percentage of time in open arms. A. laxiflora, C. ambrosioides and M. pudica also reduced the percentage of entries and time in closed arms. In addition, C. ambrosioides, M. pyrifolia and M. pudica showed antipyretic activity by reducing the body temperature. The results suggested that C. ambrosioides, M. pyrifolia and M. pudica posses anxiolytic-like and antipyretic activities while A. laxiflora possesses only anxiolytic-like properties. These plants could be helpful in the treatment of anxiety and fever in traditional medicine in Cameroon.

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Authors+Show Affiliations

Bum EN
Department of Biological Sciences, Faculty of Sciences, University of Ngaoundéré, PO Box 454 Ngaoundéré, Cameroon. eli_bum@yahoo.fr
Soudi S
No affiliation info available
Ayissi ER
No affiliation info available
Dong C
No affiliation info available
Lakoulo NH
No affiliation info available
Maidawa F
No affiliation info available
Seke PF
No affiliation info available
Nanga LD
No affiliation info available
Taiwe GS
No affiliation info available
Dimo T
No affiliation info available
Njikam N
No affiliation info available
Rakotonirina A
No affiliation info available
Rakotonirina SV
No affiliation info available
Kamanyi A
No affiliation info available

MeSH

Analysis of VarianceAnimalsAnti-Anxiety AgentsAnxietyBehavior, AnimalBody TemperatureCameroonChenopodium ambrosioidesDose-Response Relationship, DrugFeverMaleMaze LearningMedicine, TraditionalMiceMimosaMotor ActivityPhytotherapyPlant ExtractsPlants, MedicinalPsychological TestsStress, Physiological

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22754066

Citation

Bum, E Ngo, et al. "Anxiolytic Activity Evaluation of Four Medicinal Plants From Cameroon." African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM, vol. 8, no. 5 Suppl, 2011, pp. 130-9.
Bum EN, Soudi S, Ayissi ER, et al. Anxiolytic activity evaluation of four medicinal plants from Cameroon. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):130-9.
Bum, E. N., Soudi, S., Ayissi, E. R., Dong, C., Lakoulo, N. H., Maidawa, F., Seke, P. F., Nanga, L. D., Taiwe, G. S., Dimo, T., Njikam, N., Rakotonirina, A., Rakotonirina, S. V., & Kamanyi, A. (2011). Anxiolytic activity evaluation of four medicinal plants from Cameroon. African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM, 8(5 Suppl), 130-9. https://doi.org/10.4314/ajtcam.v8i5S.19
Bum EN, et al. Anxiolytic Activity Evaluation of Four Medicinal Plants From Cameroon. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):130-9. PubMed PMID: 22754066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic activity evaluation of four medicinal plants from Cameroon. AU - Bum,E Ngo, AU - Soudi,S, AU - Ayissi,E R, AU - Dong,C, AU - Lakoulo,N H, AU - Maidawa,F, AU - Seke,P F E, AU - Nanga,L D, AU - Taiwe,G S, AU - Dimo,T, AU - Njikam,Njifutie, AU - Rakotonirina,A, AU - Rakotonirina,S V, AU - Kamanyi,A, Y1 - 2011/07/03/ PY - 2012/7/4/entrez PY - 2011/1/1/pubmed PY - 2013/1/10/medline KW - Agitation KW - Anxiety KW - Medicinal plants KW - Traditional medicine SP - 130 EP - 9 JF - African journal of traditional, complementary, and alternative medicines : AJTCAM JO - Afr J Tradit Complement Altern Med VL - 8 IS - 5 Suppl N2 - Afrormosia laxiflora (A. laxiflora), Chenopodium ambrosioides (C. ambrosioides), Microglossa pyrifolia (M. pyrifolia) and Mimosa pudica (M. pudica) are plants used in traditional medicine in Cameroon to treat insomnia, epilepsy, anxiety, and agitation. They were evaluated for their anxiolytic like activity in mice. Animal models (elevated plus maze and stress-induced hyperthermia tests) were used. The four plants showed anxiolytic activity. In stress-induced hyperthermia test, A. laxiflora, C. ambrosioides, M. pyrifolia and M. pudica significantly antagonised the increase of temperature. ΔT° decreased from 0.75°C in the control group to 0.36°C at the dose of 110 mg/kg for A. laxiflora; from 1°C in the control group to -1.1°C at the dose of 120 mg/kg for C. ambrosioides; from 1.7°C in the control group to 0.2°C at the dose of 128 mg/kg for M. pyrifolia and from 1.3°C in the control group to 0.5°C at the dose of 180 mg/kg for M. pudica. In the elevated plus maze test, the four plants increased the number of entries into, percentage of entries into, and percentage of time in open arms. A. laxiflora, C. ambrosioides and M. pudica also reduced the percentage of entries and time in closed arms. In addition, C. ambrosioides, M. pyrifolia and M. pudica showed antipyretic activity by reducing the body temperature. The results suggested that C. ambrosioides, M. pyrifolia and M. pudica posses anxiolytic-like and antipyretic activities while A. laxiflora possesses only anxiolytic-like properties. These plants could be helpful in the treatment of anxiety and fever in traditional medicine in Cameroon. SN - 2505-0044 UR - https://www.unboundmedicine.com/medline/citation/22754066/Anxiolytic_activity_evaluation_of_four_medicinal_plants_from_Cameroon_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22754066/ DB - PRIME DP - Unbound Medicine ER -